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Product Information

TB500 (Thymosin β-4 Fragment) | CAS 885340-08-9

Chemical Identity

• Molecular Formula: C₃₈H₆₈N₁₀O₁₄ 

• Molecular Weight: 889.01 g/mol 

• Appearance: White to off-white lyophilized powder 

Biological Functions
TB500 is a synthetic peptide fragment derived from the active region of thymosin β-4. Its core activities include:

1. Tissue Regeneration:

   • Promotes actin polymerization to accelerate repair of muscles, tendons, and ligaments 

   • Enhances extracellular matrix synthesis (e.g., collagen, laminin) 

2. Anti-Inflammatory Action:

   • Inhibits pro-inflammatory cytokines (TNF-α, IL-1β), reducing localized inflammation 

3. Angiogenesis:

   • Stimulates VEGF signaling to improve microcirculation in ischemic tissues 

4. Cell Migration:

   • Facilitates keratinocyte movement and endothelial cell differentiation, supporting wound healing 

Research Applications

• Musculoskeletal Studies: Models of tendonitis, muscle strain, and joint injury recovery

• Cardiovascular Research: Myocardial repair mechanisms post-ischemia 

• Dermal Repair: Evaluation of granulation tissue formation and epithelialization 

Stability & Handling

• Storage: Lyophilized powder

  • ≤7 days at 4°C 

  • Reconstitution: Requires sterile buffer or bacteriostatic water; gentle swirling recommended to prevent denaturation 

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  • Core Characteristics

    1. Structural Data

       • Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

       • Formula: C₃₈H₆₈N₁₀O₁₄ | MW: 889.01 g/mol

    2. Physicochemical Parameters

       • Form: White lyophilized powder (amorphous)

       • Solubility: Freely soluble in water (≥50 mg/mL) and weak acidic buffers (pH 5.0–6.5)

       • Stability:

         • Solid state: ≥24 months at -20°C (desiccated, protected from light)

         • Solution: ≤72 hours at 4°C (recommended for immediate use)

       • Thermodynamic Data (predicted):

         • Melting point: 215–218°C (decomposition)

         • Boiling point: 1405.0±65.0°C (760 mmHg)

         • Flash point: 803.5±34.3°C

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  • Company Introduction

    csxj Technology Co., Ltd. is an innovative technology enterprise specializing in the field of weight management and metabolic health. We are dedicated to the R&D, production, and supply of high-quality solutions based on cutting-edge biotechnology for the global market, with core expertise in GLP-1-related products and high-purity active ingredients. Leveraging robust scientific capabilities and a stringent quality management system, we consistently deliver safe, efficient weight management and metabolic products and materials to meet diverse client needs. Driven by technological innovation and a customer-centric approach, we collaborate with partners to advance the health industry and empower global users in achieving healthier lifestyles.

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  • Introduction to transportation
    We usually use a safe shipping method and do not require you to go through any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team that 100% guarantees the safe delivery of your package. If anything happens to your package, we promise to send it again for free. Enjoy the second free reissue policy. We can safely ship large parcels of 1000-2000kg/time without any customs issues. Our mission is always to put safety first.

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