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Product Information

1.  

   ⚕️ 1. Core Bioactivity & Mechanism

   • Selective Activation of Innate Repair Receptor (IRR):
     Cibinetide specifically binds to the heterodimeric IRR (formed by EPOR and CD131/β-common receptor), triggering tissue-protective, anti-inflammatory, and reparative signaling pathways.

   • Non-Erythropoietic:
     As an EPO derivative, it retains EPO’s tissue-protective functions without stimulating hematopoiesis, avoiding thrombosis risks associated with EPO.

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   🧪 2. Primary Research Applications

   Neuroprotection & Pain Management

   • Diabetic Neuropathy:
     Alleviates neuropathic pain and paresthesia; increases corneal small nerve fiber density in diabetes/sarcoidosis-related nerve damage.

   • Neuroinflammation Modulation:
     Suppresses spinal microglial activation, reduces pro-inflammatory cytokine release, and mitigates chronic neuropathic pain.

   Metabolism & Diabetic Complications

   • Glucose Regulation:
     Significantly improves glucose tolerance and reduces AUC glucose in diabetic rat models (30 μg/kg), with no direct effect on weight/fat metabolism.

   • Renal Protection:
     Attenuates cisplatin-induced nephrotoxicity and reduces proteinuria in diabetic nephropathy.

   Anti-Inflammation & Tissue Repair

   • Myocardial Infarction & Ischemic Repair:
     Promotes endothelial progenitor cell proliferation/migration, enhancing angiogenesis and blood flow recovery in ischemic tissues.

   • Wound Healing:
     Accelerates wound closure in diabetic mice by upregulating VEGF expression and reducing oxidative stress.

   Immunomodulation

   • Autoimmune Diseases:
     Dose-dependently reduces neuroinflammation and severity in experimental autoimmune encephalomyelitis (EAE) models.

   • Inflammatory Microenvironment Control:
     Inhibits pro-inflammatory cytokine secretion in macrophages; potential applications in rheumatoid arthritis.

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   ⚠️ 3. Current Status & Usage Restrictions

   • Research Phase:
     Cibinetide remains in preclinical/clinical trials (e.g., Phase II for diabetic macular edema/neuropathy) and is NOT an approved therapeutic.

   • Use Limitations:
     Strictly for research reagents or pharmaceutical intermediates. Prohibited for human/pet use or commercial weight-loss products.

Company Introduction

csxj Technology Co., Ltd. is an innovative technology enterprise specializing in the field of weight management and metabolic health. We are dedicated to the R&D, production, and supply of high-quality solutions based on cutting-edge biotechnology for the global market, with core expertise in GLP-1-related products and high-purity active ingredients. Leveraging robust scientific capabilities and a stringent quality management system, we consistently deliver safe, efficient weight management and metabolic products and materials to meet diverse client needs. Driven by technological innovation and a customer-centric approach, we collaborate with partners to advance the health industry and empower global users in achieving healthier lifestyles.

Introduction to transportation
We usually use a safe shipping method and do not require you to go through any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team that 100% guarantees the safe delivery of your package. If anything happens to your package, we promise to send it again for free. Enjoy the second free reissue policy. We can safely ship large parcels of 1000-2000kg/time without any customs issues. Our mission is always to put safety first.

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