High quality pruity 99% the product ofBrimonidineCAS59803-98-4igh quality
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59803-98-4
Industrial Grade
99%
any port of china
Dideu
25kg/bag
2025-08-17
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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DescriptionECHEMI Editorial ReferenceBrimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.
Solid
Brimonidine is a quinoxaline derivative, a secondary amine and a member of imidazoles. It has a role as an adrenergic agonist, an antihypertensive agent and an alpha-adrenergic agonist.|Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists. Alpha-2 adrenergic agonists are members of the ocular hypotensive agent drug class that are used in the chronic treatment of glaucoma. Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular pressure, is critical since glaucoma is considered to be a common cause of blindness worldwide. Ophthalmically, brimonidine is used to lower intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Because it is oxidately stable, brimonidine is associated with fewer reports of ocular allergic reactions compared to other alpha-2 adrenergic agonists. The ophthalmic solution of brimonidine was first approved by the FDA in 1996 as Alphagan and brimonidine is the only selective alpha-adrenergic receptor agonist approved for chronic treatment in glaucoma. Brimonidine is also found in ophthalmic solutions in combination with [brinzolamide] under the market name Simbrinza for the reduction in intraocular pressure. Unlike nonselective beta-blockers used in ocular hypertension, brimonidine is not associated with significantly adverse cardiopulmonary side effects. Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or at high risk for, cardiopulmonary disease. The topical form of brimonidine was approved by the FDA in August 2013 for the symptomatic treatment of persistent facial erythema of rosacea in adults. It is marketed under the brand name Mirvaso. Brimonidine is the first topical treatment approved for facial erythema of rosacea.|Brimonidine is an alpha-Adrenergic Agonist. The mechanism of action of brimonidine is as an Adrenergic alpha-Agonist.|Brimonidine is an imidazole derivative and a selective alpha-2 adrenergic receptor agonist. Upon ocular administration, brimonidine acts on the blood vessels causing them to constrict which leads to a decrease in the production of aqueous humor. Brimonidine also enhances the uveoscleral outflow of aqueous humor. This reduces intraocular pressure.|A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.Basic Info-
Product Name:
Brimonidine
Other Name:6-Quinoxalinamine,5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-;5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine;UK 14304;5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline;UK 14304-18;Brimonidine;Bromoxidine;AGN 190342;Lyuksfen;109826-55-3
CAS No.:59803-98-4
Molecular Formula:C11H10BrN5
InChIKeys:InChIKey=XYLJNLCSTIOKRM-UHFFFAOYSA-N
Molecular Weight:292.14
Exact Mass:292.13
UNII:E6GNX3HHTE
NSC Number:318825
DSSTox ID:DTXSID3045221
NCI Thesaurus Code:C65269
ATC Code:D11AX21|S01EA05|D - Dermatologicals|S - Sensory organs
HScode:2934999090
Categories:
Characteristics-
PSA:
62.2
XLogP3:0.6
Appearance:Solid
Density:1.8±0.1 g/cm3
Melting Point:252 °C
Boiling Point:432.6ºC
Flash Point:215.4±31.5 °C
Refractive Index:1.798
Water Solubility:H2O: soluble (1.5 mg/mL);45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
Storage Conditions:Store at RT
PKA:7.78None
Dissociation Constants:7.78
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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Certifications:
ISO Certificate,REACH
">Company Profile -
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
India
Brimonidine
10 G Jul 17, 2025 Post an enquiry for this product