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DACARBAZINE  4342-03-4 buy - large image1
DACARBAZINE  4342-03-4 buy - image1

DACARBAZINE 4342-03-4

1 Inquiries

Unit Price: Get Latest Price
CAS No.:

4342-03-4

Content:

98%

Port:

shanghai

Packaging:

100g

Price valid (until):

2025-03-04

Company Type:
Trader
Location:
China
Qualification:
Main Products:

13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Dacarbazine (brand names DTIC, DTIC-Dome; also known as DIC or imidazole carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin's lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
    Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.
    Dacarbazine is normally administered by intravenous infusion (IV) under the immediate supervision of a doctor or nurse. Dacarbazine is bioactivated in liver by demethylation to "MTIC" and then to diazomethane, which is an alkylating agent.
    It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

    Physical state Yellowish or reddish powder
    Colour IVORY MICROCRYSTALINE SUBSTANCE
    Odour no data available
    Melting point/ freezing point 255°C(dec.)(lit.)
    Boiling point or initial boiling point and boiling range 118°C/1.3mmHg(lit.)
    Flammability no data available
    Lower and upper explosion limit / flammability limit no data available
    Flash point 108°C(lit.)
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility less than 0.1 mg/mL at 15°C
    Partition coefficient n-octanol/water (log value) no data available
    Vapour pressure no data available
    Density and/or relative density 1.48 g/cm3
    Relative vapour density no data available
    Particle characteristics no data available

    Basic Info
    Product Name:

    Dacarbazine

    Other Name:

    1H-Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazen-1-yl)-;Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazeno)-;1H-Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazenyl)-;Imidazole-4(or 5)-carboxamide,5(or 4)-(3,3-dimethyl-1-triazeno)-;5-(3,3-Dimethyl-1-triazen-1-yl)-1H-imidazole-4-carboxamide;4-(Dimethyltriazeno)imidazole-5-carboxamide;5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboxamide;5(or 4)-(3,3-Dimethyl-1-triazeno)imidazole-4(or 5)carboxamide;5(4)-(3,3-Dimethyl-1-triazeno)imidazole-4(5)-carboxamide;4(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide;5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide;Dacarbazine;NSC 45388;5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide;(Dimethyltriazeno)imidazolecarboxamide;DTIC;5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide;Biocarbazine R;Deticene;5-(3,3′-Dimethyl-1-triazeno)imidazole-4-carboxamide;Dacarbasine;DTIE;DTIC-Dome;NCI C04717;ICDT;ICDMT;DIC;Detimedac;37626-23-6

    CAS No.:

    4342-03-4

    Molecular Formula:

    C6H10N6O

    InChIKeys:

    InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N

    Molecular Weight:

    182.18

    Exact Mass:

    182.18

    EC Number:

    224-396-1

    UNII:

    7GR28W0FJI

    NSC Number:

    759610|45388

    DSSTox ID:

    DTXSID0020369

    NCI Thesaurus Code:

    C411

    Color/Form:

    IVORY MICROCRYSTALINE SUBSTANCE

    ATC Code:

    L - Antineoplastic and immunomodulating agents

    HScode:

    2934999090

    Characteristics
    PSA:

    99.73000

    XLogP3:

    -0.24

    Appearance:

    Dacarbazine appears as white to ivory microcrystals or off-white crystalline solid. (NTP, 1992)

    Density:

    1.5±0.1 g/cm3

    Melting Point:

    205 °C

    Boiling Point:

    456.3±55.0 °C at 760 mmHg

    Flash Point:

    229.7±31.5 °C

    Refractive Index:

    1.678

    Water Solubility:

    Slightly soluble in water, DMSO and ethanol/n

    Storage Conditions:

    2-8°C

    Dissociation Constants:

    pKa= 4.42

    Experimental Properties:

    Sensitive to oxidation; stable in neutral solutions in absence of light. Extremely light-sensitive: rapidly undergoes chemical decomposition to form 4-diazoimidazole-5-carboxamide ... .

    Air and Water Reactions:

    Insoluble in water.

    Reactive Group:

    Amides and Imides

    Reactivity Profile:

    DACARBAZINE decomposes explosively at its melting point (250°C). Decomposes in the presence of light. Sensitive to oxidation.

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Acute toxicity - Category 4, Dermal

    Skin irritation, Category 2

    Eye irritation, Category 2

    Acute toxicity - Category 4, Inhalation

    Specific target organ toxicity – single exposure, Category 3

    Germ cell mutagenicity, Category 1B

    Carcinogenicity, Category 1B

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    H340 May cause genetic defects

    H350 May cause cancer

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P203 Obtain, read and follow all safety instructions before use.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P317 Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P332+P317 If skin irritation occurs: Get medical help.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

    Location:

    Room 1623,Building A, ZhongqiaoCenter,Goverment District,Hefei city,Anhui Province,China

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    5-10

    Year of Establishment:

    2019

  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    DACARBAZINE

    100 G Jul 15, 2025
    Post an enquiry for this product
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