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High Quality Entinostat CAS209783-80-2 Light Yellow Solid Raw Material

Name: High Quality Entinostat CAS209783-80-2 Light Yellow Solid Raw Material
Brand: HyperChem
SKU: pr2508041036
Price: 220 USD
Availability: InStock

3 Inquiries

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CAS No.:

209783-80-2

Grade:

Pharmaceutical Grade

Content:

98%

Port:

Shanghai

Brand:

HyperChem

Packaging:

Box/Drum

Sample Available:

Yes

Price valid (until):

2025-08-18

Contact Supplier

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Entinostat
CAS number	209783-80-2
EINECS number
Synonym	MS275;MS275;CS-189;Carbamicacid,N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-,3-pyridinylmethylester;entinostat;3-pyridinylmethyl[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate,N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide;N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamicacid3-pyridinylmethylester;Entinostat/MS-275;Nsc706995
Description	Entinostat is a drug primarily known for its role as a histone deacetylase (HDAC) inhibitor.
Structure
Molecular Formula	C21H20N4O3
Molecular Weight	376.41 g/mol
Appearance	Light Yellow Solid
Quality Standard	In-house
Assay	98%
Sample package	Box/Drum
Commercial package	Aluminium Tin, Fiber drum
Origin	China

More Info

Entinostat, Syndax Pharmaceuticals' lead product candidate, has been studied in 800 cancer patients for objective tumor response in solid tumors and malignant hematologic diseases. Entinostat selectively targets the HDAC subtype most relevant to tumor biology, normalizing the expression of uncontrolled genes in tumor cells and restoring sensitivity to other targeted therapies. Entinostat is being prepared for pivotal Phase III clinical trials due to its excellent clinical results in breast and lung cancer.

Mechanism of action

Entinostat inhibits HDAC enzymes, which are involved in regulating gene expression by modifying histone proteins. By inhibiting HDACs, entinostat can lead to increased acetylation of histones, which can alter chromatin structure and activate genes involved in cell growth, differentiation, and apoptosis (programmed cell death).

Side Effects

Entinostat has shown manageable side effects in clinical trials, including fatigue, nausea, anemia, and diarrhea.

Package Image

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively.
Entinostat is a member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyridines, a carbamate ester, a substituted aniline, a primary amino compound and a member of benzamides. It derives from a 1,2-phenylenediamine.|Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.|Entinostat is a synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.

Basic Info

Product Name:

Entinostat

Other Name:

Carbamic acid,N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-,3-pyridinylmethyl ester;Carbamic acid,[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-,3-pyridinylmethyl ester;MS 275;MS 27-275;MS 275-27;SNDX 275;Entinostat;(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate;442532-99-2

CAS No.:

209783-80-2

Molecular Formula:

C21H20N4O3

InChIKeys:

InChIKey=INVTYAOGFAGBOE-UHFFFAOYSA-N

Molecular Weight:

376.4085

Exact Mass:

376.41

UNII:

1ZNY4FKK9H

NSC Number:

706995

DSSTox ID:

DTXSID0041068

NCI Thesaurus Code:

C1863

ATC Code:

L - Antineoplastic and immunomodulating agents

HScode:

29333990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

106

XLogP3:

Appearance:

solid

Density:

1.3±0.1 g/cm3

Melting Point:

159-160 °C

Boiling Point:

566.7°C at 760 mmHg

Flash Point:

296.6±30.1 °C

Refractive Index:

1.672

Water Solubility:

DMSO: 38 mg/mL, soluble

Storage Conditions:

−20°C

Vapor Pressure:

7.31E-13mmHg at 25°C

See More Entinostat Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Entinostat Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Austria	Entinostat	5 G	Oct 27, 2025
United States	Entinostat	500 MG	Aug 3, 2025
United States	Entinostat	10 G	Jun 3, 2026

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High Quality Entinostat CAS209783-80-2 Light Yellow Solid Raw Material

Product Description

Seller Information