98% 2-Deoxy-D-ribose CAS 533-67-5

2-Deoxy-D-ribose More Info

2-Deoxy-D-ribose (CAS 533-67-5) is a monosaccharide derivative and a key structural component of DNA, where it forms the backbone of the DNA molecule by linking with phosphate groups and  bases. First identified in the early 20th century during nucleic acid research, this pentose sugar is distinguished from ribose by the absence of a hydroxyl group at the 2' position, which is critical for DNA stability. It is synthesized through chemical or enzymatic methods and is widely used in biochemical research, pharmaceutical development, and molecular biology applications. Its role in DNA structure makes it a fundamental compound for studying genetic material and nucleic acid chemistry.

Applications and Fields of Use

2-Deoxy-D-ribose is primarily utilized in molecular biology and biochemistry for DNA synthesis, sequencing, and enzymatic studies. It serves as a precursor in the production of nucleoside analogs, which are essential for antiviral and anticancer drug development. Additionally, it is employed in diagnostic assays and research tools to investigate DNA repair mechanisms and cellular metabolism. The compound also finds applications in carbohydrate chemistry for synthesizing modified sugars and glycoconjugates. Beyond pharmaceuticals, it is used in biotechnology for PCR optimization and as a reference standard in analytical laboratories to validate nucleic acid-related experiments.

Market and Industry Relevance

The global market for 2-Deoxy-D-ribose is driven by its indispensable role in life sciences and pharmaceutical industries. Academic institutions, research laboratories, and biotech companies are the primary consumers, utilizing it for DNA-related studies and drug discovery. The increasing demand for personalized medicine and advanced therapies, such as gene editing and mRNA vaccines, has further amplified its relevance. Major suppliers cater to both small-scale research needs and bulk industrial applications, with purity grades ranging from technical to pharmaceutical standards. Emerging markets in Asia-Pacific and Europe are witnessing growth due to expanding biotechnology sectors and government-funded genomic research initiatives.

Precautions and Considerations

When handling 2-Deoxy-D-ribose, standard laboratory safety protocols should be followed, including the use of personal protective equipment (PPE) to avoid inhalation or skin contact. Although it is not classified as highly hazardous, proper storage in a cool, dry place is essential to maintain stability. Researchers should verify the purity grade (e.g., ≥98% for most applications) and ensure compatibility with experimental conditions, as impurities may affect enzymatic reactions. For industrial-scale use, regulatory compliance with regional chemical safety guidelines (e.g., REACH in the EU) must be confirmed. Disposal should adhere to local environmental regulations for organic compounds.

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