USP 99% Heparin sodium 9041-08-1

Heparin sodium More Info

Heparin sodium (CAS 9041-08-1) is a naturally occurring glycosaminoglycan anticoagulant derived from animal tissues, primarily porcine intestinal mucosa. First isolated in 1916, this complex mixture of sulfated polysaccharides revolutionized anticoagulation therapy and remains on the WHO's List of Essential Medicines. The compound's molecular weight ranges from 3-30 kDa with a distinctive pentasaccharide sequence responsible for its antithrombin III binding activity. Modern manufacturing involves rigorous purification processes to meet pharmacopeial standards (USP/EP), with strict regulatory oversight following past contamination incidents. Its biological origin and structural heterogeneity present unique quality control challenges that have driven development of synthetic alternatives.

Applications and Fields of Use

Clinically, heparin sodium serves as a rapid-acting parenteral anticoagulant for thromboprophylaxis in surgical settings and treatment of venous thromboembolism. It is indispensable in extracorporeal circuits including hemodialysis and cardiopulmonary bypass procedures. The pharmaceutical industry utilizes crude heparin as starting material for low molecular weight heparin (LMWH) production through controlled depolymerization. Research applications include cell culture systems requiring anticoagulation and studies of blood coagulation cascades. Emerging non-anticoagulant applications investigate its anti-inflammatory properties and potential in sepsis management, though these remain experimental.

Market and Industry Relevance

The global heparin market exceeds $7 billion annually, with China supplying over 80% of the active pharmaceutical ingredient (API). Increasing surgical volumes and rising cardiovascular disease prevalence drive steady demand growth. The market features significant price stratification between pharmaceutical-grade material (>140 IU/mg) and technical-grade products. Recent years have seen expansion of biosynthetic heparin alternatives, though animal-derived heparin still dominates therapeutic use. Regulatory requirements continue to intensify, with major markets implementing DNA-level species identification and impurity profiling to ensure supply chain integrity and prevent adulteration.

Precautions and Considerations

Therapeutic use requires careful monitoring for heparin-induced thrombocytopenia (HIT) and bleeding complications. Strict cold chain maintenance (2-8°C) is essential for stability, with freeze-thaw cycles to be avoided. Quality verification must include potency testing (USP units), endotoxin levels, and identity confirmation through nuclear magnetic resonance (NMR). Occupational exposure limits apply due to potential airborne particulate risks during manufacturing. Regulatory compliance requires full traceability of animal tissue origin and adherence to evolving pharmacopeial standards across jurisdictions (USP, EP, JP). Special handling protocols are necessary for large quantities due to its hygroscopic nature and biological activity.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.