Factory provided BP Prostaglandin E1 745-65-3

Prostaglandin E1 More Info

Prostaglandin E1 (PGE1, CAS: 745-65-3) is a naturally occurring eicosanoid derived from arachidonic acid metabolism, serving as a crucial autocrine and paracrine signaling molecule in human physiology. This unsaturated fatty acid derivative exists as a viscous liquid at room temperature and demonstrates exceptional biological activity at extremely low concentrations. As the first prostaglandin to be isolated and characterized, it represents a benchmark compound in lipid mediator research. Modern production utilizes both biotechnological synthesis through enzymatic conversion and chemical synthesis routes to achieve pharmaceutical-grade material with stringent purity requirements (>98% by HPLC). Its inherent instability in aqueous solutions necessitates specialized formulation approaches for clinical applications.

Key Applications

PGE1 has established therapeutic roles across multiple medical specialties due to its vasodilatory, anti-inflammatory, and cytoprotective properties. In cardiovascular medicine, it serves as a critical treatment for peripheral arterial diseases and ductus arteriosus management in neonates. Urology applications include intracavernosal injections for erectile dysfunction therapy, while gastroenterology utilizes its mucosal protective effects. Emerging applications span tissue engineering (as a stem cell differentiation modulator) and dermatology (for wound healing acceleration). The compound's ability to regulate platelet aggregation also makes it valuable in hematological research and anticoagulation protocols.

Market Dynamics

The global PGE1 market is projected to maintain steady growth (CAGR 4.2% through 2030), driven by expanding geriatric populations requiring vascular therapies and increasing neonatal ICU admissions. Asia-Pacific dominates production capacity with China and India as key manufacturing hubs, while North America and Europe lead in therapeutic innovation and premium-priced formulations. Market segmentation shows injectable formulations commanding 68% revenue share, with growing interest in sustained-release delivery systems. The compound's inclusion in WHO Essential Medicines List ensures continued demand in emerging markets, though pricing pressures exist from generic competition. Recent patent expirations have stimulated development of novel analogs and combination therapies.

Handling & Regulatory Considerations

PGE1 requires strict cold chain maintenance (typically -20°C storage with desiccants) due to thermal and oxidative instability. Handling must follow potent compound protocols with appropriate PPE including nitrile gloves and eye protection. Regulatory frameworks classify it as a prescription drug substance requiring cGMP compliance for pharmaceutical use, with additional controls for controlled substance applications in certain jurisdictions. Documentation must include comprehensive stability data, chiral purity certification, and endotoxin testing reports. Special transport regulations apply for temperature-sensitive shipments, requiring validated packaging with temperature monitors. Clinical applications demand rigorous batch-to-batch consistency verification due to narrow therapeutic windows in critical care usage.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.