2,5-Dithiobiurea 98%Min White to light yellow crystalline powder RC00097

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Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

Product Name: ‌ 2,5-Dithiobiurea
‌ Synonyms: ‌

Formamidine disulfide

Dithiocarbamoylcarbamimidothioic acid

N-(Aminomethanethioyl)carbamimidothioic acid

2,5-Dithiobiurea
‌ CAS Registry Number: ‌ 142-46-1
‌ Chemical Formula: ‌ C2H6N4S2
‌ Molecular Weight: ‌ 150.23 g/mol

Key Properties

‌ Physical Appearance: ‌

Typically a white  to light yellow crystalline powder.

‌ Melting Point: ‌

Decomposes around 20 3 -2 12 °C (exact mp can vary; often reported with decomposition).

‌ Solubility: ‌

Sparingly soluble in cold water.

More soluble in hot water (decomposition possible).

Insoluble or very slightly soluble in common organic solvents (e.g., ethanol, diethyl ether, acetone, chloroform).

‌ Chemical Properties: ‌

Contains two thiocarbonyl (C=S) groups connected via a disulfide (-S-S-) bridge or tautomeric forms involving thiols (-SH).

Acts as a reducing agent due to the disulfide bond.

Can act as a ligand for metal ions, forming complexes.

Sensitive to strong oxidizing and reducing agents.

Sensitive to prolonged exposure to heat and light; may decompose.

‌ Stability: ‌

Store in a cool (< 10°C recommended), dry, dark place (e.g., refrigerator).

Hygroscopic; keep container tightly sealed under inert atmosphere (e.g., nitrogen or argon).

Limited shelf life; check periodically for decomposition (color change, odor).

Synthesis

Commonly synthesized by:

Oxidation of thiourea (e.g., using bromine or iodine).

Reaction of ammonium thiocyanate with bromine.

Applications

2,5-Dithiobiurea is primarily a ‌ specialty chemical reagent ‌ used in research and organic synthesis:

‌ Precursor for Heterocycles: ‌

Used in the synthesis of various sulfur and nitrogen-containing heterocyclic compounds (e.g., thiadiazoles, triazines).

‌ Metal Chelation/Complexation: ‌

Can form complexes with transition metals (e.g., copper, nickel, platinum group metals), potentially useful in catalysis or material science.

‌ Redox Chemistry: ‌

Used as a mild reducing agent in specific synthetic transformations.

‌ Pharmacological Research: ‌

Derivatives of thiobiureas have been investigated for potential biological activities (e.g., antiviral, antitumor), though 2,5-dithiobiurea itself is primarily an intermediate.

‌ Analytical Chemistry: ‌

Potential use as a reagent for specific metal ion detection or separation.

Handling & Safety (CRITICAL)

‌ Hazard Statements (GHS - Typical): ‌

‌ H315: ‌ Causes skin irritation.

‌ H319: ‌ Causes serious eye irritation.

‌ H335: ‌ May cause respiratory irritation.

‌ H302: ‌ Harmful if swallowed.

‌ Precautionary Statements (P-Codes - Typical): ‌

‌ P261: ‌ Avoid breathing dust/fume/gas/mist/vapours/spray.

‌ P264: ‌ Wash hands thoroughly after handling.

‌ P271: ‌ Use only outdoors or in a well-ventilated area.

‌ P280: ‌ Wear protective gloves/protective clothing/eye protection/face protection.

‌ P305+P351+P338: ‌ IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

‌ P310: ‌ Immediately call a POISON CENTER or doctor/physician.

‌ Handling: ‌

Handle only in a well-ventilated fume hood.

Wear appropriate PPE: Lab coat, chemical-resistant gloves (e.g., nitrile), safety goggles or face shield.

Avoid contact with skin, eyes, and clothing. Avoid inhalation of dust.

Prevent dispersion of dust.

‌ Storage: ‌

Store tightly sealed, under inert atmosphere (N₂ or Ar), protected from light in a refrigerator (2-8°C).

Keep container dry.

Store away from incompatible materials: strong oxidizing agents, strong acids, strong bases.