N-(2-bromo-5-fluorophenyl)acetamide RC00169

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

Product Name:  N-(2-Bromo-5-fluorophenyl)acetamide
CAS Registry Number:  1009-06-9
Synonyms:

1-(2-Bromo-5-fluorophenyl)acetamide

Acetamide, N-(2-bromo-5-fluorophenyl)-

2'-Bromo-5'-fluoroacetanilide

N-Acetyl-2-bromo-5-fluoroaniline

Molecular Formula:  C₈H₇BrFNO
Molecular Weight:  232.05 g/mol

Appearance

Typically a white to off-white or light tan crystalline solid or powder.

Key Chemical Properties

Functional Groups:  Secondary amide (acetamide), aryl bromide (bromobenzene), aryl fluoride (fluorobenzene).

Reactivity:

The  aryl bromide (C-Br bond)  is highly susceptible to cross-coupling reactions (e.g., Suzuki, Stille, Negishi coupling) for introducing new substituents.

The  aryl fluoride (C-F bond) , while less reactive than bromide, can participate in nucleophilic aromatic substitution (SNAr) with strong nucleophiles, especially given the electron-withdrawing acetamide group ortho to it.

The  amide group  can be hydrolyzed (acidic or basic conditions) to regenerate the corresponding aniline derivative, N-(2-bromo-5-fluorophenyl)amine, which is valuable for diazotization or further derivatization. It can also participate in directed ortho-metalation (DoM) or be deprotonated for further functionalization under strong bases.

Can act as a directing group in transition metal-catalyzed C-H activation reactions.

Typical Applications

Organic Synthesis Intermediate:  Primarily used as a versatile building block in multi-step organic syntheses, especially in medicinal chemistry and agrochemical research.

Pharmaceutical Intermediates:  Key precursor for synthesizing more complex molecules targeting various biological activities. The halogen handles allow for diversification at specific positions on the aromatic ring.

Agrochemical Intermediates:  Used in the synthesis of potential herbicides, fungicides, or insecticides.

Material Science:  Potential building block for specialty polymers or functional materials.

Research Chemical:  Utilized in developing new synthetic methodologies, particularly those involving cross-coupling or C-H functionalization.

Purity

Commonly available in research quantities at purities of  97% to 99%  (determined by HPLC, GC, or NMR). Higher purities (e.g., >99%) may be available upon request.

Handling & Storage

Storage Conditions:  Store in a cool (2-8°C), dry place, protected from light and moisture, in a well-sealed container under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Minimize exposure to air.

Stability:  Stable under recommended storage conditions. May decompose if exposed to strong acids, bases, oxidizing agents, or prolonged heat/light.

Safety Information (GHS Classification - Typical)

Hazard Statements (H):

H315:  Causes skin irritation.

H319:  Causes serious eye irritation.

H335:  May cause respiratory irritation.

H302+H312:  Harmful if swallowed or in contact with skin (depending on specific toxicology data).

Precautionary Statements (P):

P261:  Avoid breathing dust/fume/gas/mist/vapours/spray.

P264:  Wash hands thoroughly after handling.

P271:  Use only outdoors or in a well-ventilated area.

P280:  Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338:  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P312:  Call a POISON CENTER or doctor/physician if you feel unwell.

P302+P352:  IF ON SKIN: Wash with plenty of soap and water.

P332+P313:  If skin irritation occurs: Get medical advice/attention.

P337+P313:  If eye irritation persists: Get medical advice/attention.

P501:  Dispose of contents/container in accordance with local/regional/national/international regulations.