4-Bromotoluene

171.03

171.03

1903636

203-391-8

9E349GQ7EU

6531

DTXSID7024661

Crystals from absolute alcohol

29036990

0

3.42

White Crystalline Low Melting Mass

1.3995 g/cm³ @ Temp: 35 °C

28.5 °C

184.5 °C @ Press: 760 Torr

185 °F

1.549

H2O: <0.1 g/100 mL at 24 ºC

Store below +30°C.

1.15 mm Hg at 25 deg C.

5.9 (Air= 1)

Peritoneal-mouse LD50: 1741 mg/kg

Open flame is flammable; heated to decompose toxic bromide gas

0.00 atm-m3/mole

Dielectric constant 5.49

Insoluble in water.

Aryl Halides

P-BROMOTOLUENE is incompatible with strong oxidizing agents. (NTP, 1992)

10,076.2 gcal/gmole

III

9

UN 3077 9/PG 3

3

22-38-51/53-36/37/38

28-61-37/39-26

XS7965600

Xn,N,T

The warehouse is ventilated, low temperature and dry; stored and transported separately from oxidants and food materials

Stable under normal temperatures and pressures.

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501

H302-H315

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

UN 8027

This chemical is combustible. (NTP, 1992)

|Warning|H302 (78.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 60 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Irritant /2-Bromotoluene/

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

The major hazards encountered in the use and handling of 4-bromotoluene stem from its toxicologic properties. Exposure to 4-bromotoluene may occur through inhalation or dermal contact at sites where the substance is manufactured, used as a solvent, or used as a chemical intermediate. This substance is to be considered hazardous to health, with the potential to cause respiratory irritation and CNS depression. Entry into contaminated areas warrants the wearing of full-face mask, self-contained breathing apparatus which provides eye protection. This substance is normally stable, even under fire conditions; requiring moderate heating before ignition will occur (flash point 85 °C, closed cup). Normal procedures may be used to fight a 4-bromotoluene fire; extinguishing with water spray that blankets the fire and cools the substance below its flash point. Before transporting 4-bromotoluene, the regulatory requirements of the DOT must be consulted. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance.

moderately toxic

Bromotoluene's use as a solvent and chemical intermediate(1,2) may result in direct environmental release through evaporation and from wastes generated at sites of production or use(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 434(SRC), derived from a molecular structure estimation method(2), suggests that 4-bromotoluene will have moderate mobility in soil(SRC). Its high Henry's Law constant, 2.3X10-3 atm-cu m/mole(3), high vapor pressure, 1.15 mm Hg at 25 °C(3), and moderate adsorptivity to soil indicate that volatilization may be an important fate process from both moist and dry soil surfaces(4,SRC). A single pure culture biodegradation study has observed biooxidation of 4-bromotoluene utilizing a bacterium isolated from soil(5); however, sufficient biodegradation data are not available to predict the significance of biodegradation in the environment. No data are available pertaining to abiotic degradation of 4-bromotoluene in soil(SRC).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 434(SRC) determined from molecular structure(2), indicates that 4-bromotoluene may adsorb to sediment and particulate matter in the water column(SRC). It is expected to readily volatilize from water based on its Henry's Law constant of 2.3X10-3 atm-cu m/mole(3). Estimated half-lives for a model river and model lake are 4.3 hours and 5.3 days, respectively(4,SRC). Using a model which takes adsorption into account(7), the volatilization half-life of 4-bromotoluene in an environmental pond is estimated to be 14.9 days. According to a recommended classification scheme(6), an estimated BCF value of 230(4,SRC), based on its log Kow(5,SRC), suggests that bioconcentration in aquatic organisms is moderately high(SRC). No experimental data are available pertaining to aquatic biodegradation(SRC).|ATMOSPHERIC FATE: According to a theory of gas/particle partitioning of semivolatile organic compounds in the atmosphere(2), 4-bromotoluene, which has a vapor pressure of 1.15 mm Hg at 25 °C(1), should exist entirely in the vapor phase in the ambient atmosphere(2,SRC). Vapor-phase 4-bromotoluene should degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction is estimated to be 9.8 days(3,SRC).

The rate constant for the vapor-phase reaction of 4-bromotoluene with photochemically produced hydroxyl radicals has been estimated to be 1.6X10-12 cu m/molecule-sec at 25 °C(1,SRC); assuming an average atmospheric hydroxyl radical concn of 5X10+5 molecules/cu cm, the half-life for this reaction can be estimated to be 9.8 days(1,SRC). 4-Bromotoluene does not contain any functional groups that are susceptible to aqueous environmental hydrolysis(2); therefore, hydrolysis is not expected to be significant in water(SRC). Irradiation of 4-bromotoluene (in hexane solution) with artificial UV light above 290 nm resulted in a dehalogenation of 1.0% over a two hour period(3).

A BCF of 230 was estimated for 4-bromotoluene(SRC), using its log Kow of 3.42(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in fish and aquatic organisms is moderately high(SRC).

Using an estimation method based on molecular connectivity indices(1), the Koc for 4-bromotoluene is estimated to be 430(SRC). According to a suggested classification scheme(2), this Koc value suggests that 4-bromotoluene will have medium mobility in soil(SRC).

The Henry's Law constant of 4-bromotoluene is 2.33X10-3 atm-cu m/mole(1) which indicates that volatilization from environmental waters is probably significant, and may be rapid(2). The volatilization half-life of 4-bromotoluene from a model river (1 meter deep flowing 1 m/sec with a wind speed of 3 m/sec) and model lake (1 meter deep flowing at 0.05 m/sec with a wind speed of 0.5 m/sec) is estimated to be 4.3 hr and 5.3 days, respectively(2,SRC); these estimates do not consider the effect of adsorption to sediment which may be important(SRC). The volatilization half-life of 4-bromotoluene in an experimental pond which considers adsorption has been estimated to be 14.9 days(3,SRC).

DRINKING WATER: 4-Bromotoluene was qualitatively detected in drinking water concentrates collected from Cincinnati, OH in Oct 1978(1).

Occupational exposure may occur through inhalation or dermal contact at sites where 4-bromotoluene is manufactured, used as a solvent or used as a chemical intermediate. (SRC)

SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, eyes, mucous membranes and upper respiratory tract. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion and skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen bromide gas. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

4-bromotoluene

Benzene, 1-bromo-4-methyl-: ACTIVE

Analyte: Chlorobenzene; Matrix: air; Procedure: Gas chromatography, flame ionization detector; Desorption: 1 ml CS2, stand 30 min; Range: 0.4-10 mg/ samp; Precision: 0.025; Est LOD: 0.01 mg/samp; Interferences: none /Hydrocarbons, halogenated, Chlorobenzene/|GC METHOD FOR QUALITATIVE & QUANTITATIVE ANAL OF MIXT OF BENZYL BROMIDE (TECHNICAL PROD CONTAINED o- & p-BROMOTOLUENE CONTAMINANTS), XYLYL BROMIDE, CHLOROACETOPHENONE, ALPHA-CHLOROBENZALMALONONITRILE & DIPHENYLAMINOARSINE CHLORIDE IS PRESENTED. THE 1 UG SENSITIVITY OF THE METHOD COULD BE INCREASED BY UTILIZATION OF AN ELECTRON CAPTURE DETECTOR.