5-bromo-2-(1-methyl-1H-tetrazol-5-yl)pyridine RC00201

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for Tedizolid 】

【 Providing a complete set of intermediates and impurities for  Tedizolid 】

【 Providing a complete set of intermediates and impurities for  Tedizolid 】

Here is a detailed product specification for  5-Bromo-2-(1-methyl-1H-tetrazol-5-yl)pyridine  (CAS 380380-63-2):

1. Product Identification

Chemical Name:  5-Bromo-2-(1-methyl-1H-tetrazol-5-yl)pyridine

Synonyms:

5-Bromo-2-(1-methyl-1H-tetrazol-5-yl)pyridine

2-(1-Methyl-1H-tetrazol-5-yl)-5-bromopyridine

5-Bromo-2-(1-methyltetrazol-5-yl)pyridine

Pyridine, 5-bromo-2-(1-methyl-1H-tetrazol-5-yl)-

CAS Registry Number:  380380-63-2

Molecular Formula:  C₇H₆BrN₅

Molecular Weight:  254.06 g/mol

2. Structural Information

Canonical SMILES:  Cn1nnnc1c2nccc(Br)c2

3. Physical and Chemical Properties

Appearance:  Typically white to off-white or pale yellow crystalline powder or solid.

Melting Point:  ~155-160 °C (reported range, vendor-specific).

Solubility:

Soluble in common organic solvents (DMSO, DMF, methanol, ethanol, dichloromethane, ethyl acetate).

Sparingly soluble to insoluble in water.

Purity (Typical Commercial Grade):  ≥95% (HPLC); higher grades available (≥97%, ≥98%, ≥99%).

Storage Conditions:  Store at 2-8°C under inert atmosphere (N₂ or Ar), protected from light and moisture. Desiccate.

Stability:  Stable under recommended storage conditions. May be light-sensitive. Should be protected from strong oxidizing agents.

4. Handling and Safety (Summary - Refer to SDS)

Hazard Statements (H-Statements):  Typically includes:

H315: Causes skin irritation.

H319: Causes serious eye irritation.

H335: May cause respiratory irritation.

Precautionary Statements (P-Statements):  Typically includes:

P261: Avoid breathing dust/fume/gas/mist/vapours/spray.

P264: Wash hands thoroughly after handling.

P271: Use only outdoors or in a well-ventilated area.

P280: Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352: IF ON SKIN: Wash with plenty of soap and water.

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

Safety Data Sheet (SDS):  Must be consulted and followed prior to handling.

6. Synthesis and Applications

Primary Use:   Key Building Block  in organic synthesis, particularly medicinal chemistry.

Key Functional Groups:

Aryl Bromide (C-Br):  Enables transition-metal-catalyzed cross-coupling reactions (Suzuki-Miyaura, Stille, Negishi, Buchwald-Hartwig amination) to introduce diverse substituents at the 5-position of the pyridine ring.

1-Methyl-1H-tetrazol-5-yl:  A metabolically stable bioisostere for carboxylic acids or other heterocycles. Commonly used to enhance potency, solubility, metabolic stability, or reduce off-target effects in drug candidates.

Target Applications:

Synthesis of pharmaceutical intermediates & active pharmaceutical ingredients (APIs).

Development of kinase inhibitors, enzyme modulators, receptor ligands.

Research in agrochemicals and materials science.