(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxamide RC00256

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:   www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

Here is a detailed product description for  (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide  (CAS # 1006376-62-0):

1. Chemical Identification:  *  Chemical Name:  (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide *  CAS Registry Number:  1006376-62-0 *  Synonyms:  * (1R,2R)-rel-2-(3,4-Difluorophenyl)cyclopropanecarboxamide (often used before absolute stereochemistry confirmed) * (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid amide * trans-(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide * AZD-5213 Impurity / Intermediate (Commonly associated with Ticagrelor synthesis) *  Molecular Formula:  C₁₀H₉F₂NO *  Molecular Weight:  197.18 g/mol *  Structure:   A cyclopropane ring with a carboxamide group (-C(O)NH₂) attached to carbon 1 and a 3,4-difluorophenyl ring attached to carbon 2. The stereochemistry at carbons 1 and 2 is both (R), indicating the trans relative configuration.

2. Physical and Chemical Properties:  *  Appearance:  Typically supplied as a white to off-white crystalline solid or powder. *  Melting Point:  Specific melting point can vary slightly depending on purity and crystalline form. Literature values often range between approximately 145°C to 155°C. *  Solubility:  *  Soluble:  In common organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), dichloromethane (DCM), chloroform, methanol, ethanol, and ethyl acetate. Solubility in water is generally very low. *  Slightly Soluble/Insoluble:  In aliphatic hydrocarbons (e.g., hexane, heptane) and water. *  Optical Rotation:  Exhibits a specific optical rotation due to its chiral centers. Typical values reported are around [α]D²⁰ = +70° to +80° (c=1, MeOH), confirming the (1R,2R) enantiomeric form.  Exact value depends on solvent, concentration, and purity.  *  Chirality:  Contains two chiral centers (C1 and C2 of the cyclopropane ring) in the specific (1R,2R) absolute configuration. This defines it as a single enantiomer (enantiomerically pure compound). The relative configuration is trans. *  Stability:  Stable under standard laboratory storage conditions. Sensitive to strong oxidizing agents, strong acids, and strong bases. Should be protected from prolonged exposure to light and moisture.

3. . Handling and Safety:  *  Hazard Classification:  Generally not classified as a severe hazard under GHS. However, safety data should always be consulted. *  Safety Precautions:  *  Personal Protective Equipment (PPE):  Wear safety glasses, chemical-resistant gloves (e.g., nitrile), and a lab coat. Use adequate ventilation (fume hood). *  Handling:  Avoid contact with skin, eyes, and clothing. Avoid inhalation of dust. Avoid creating dust. *  Storage:  Store in a cool (2-8°C recommended for long-term), dry place, protected from light, in a tightly sealed container under an inert atmosphere (e.g., nitrogen or argon). *  Stability under Normal Conditions:  Stable if stored properly.