Best Price Anti-dandruff Ingredient Piroctone Olamine with CAS No 68890-66-4

1.  Description

The unique properties of Piroctone Olamine are mainly manifested in the following aspects: 1. Its anti-dandruff and anti-itch effects are superior to those of similar products. 2. It exhibits excellent solubility and compatibility, and does not precipitate or stratify when mixed with cosmetic raw materials. 3. Its anti-dandruff mechanism is unique, with extremely low irritation, and it does not cause hair loss or breakage, making it safer than similar anti-dandruff and anti-itch products.

2.  Application

Piroctoneolamine,theethanolaminesaltofthehydroxamicacidderivativePiroctone,isahydroxypyridoneanti-mycoticagent.Piroctoneolaminepenetratesthecellmembraneandformscomplexeswithironions,inhibitingenergymetabolisminmitochChemicalbookondria.Piroctoneolamine(PO)isanethanolaminesaltofthehydroxamicacidderivativePiroctone.AllCandidastrainsshowlowminimuminhibitoryconcentrations(MICs)forPiroctoneolamine(0.125-0.5μg/mL)andAmphotericinB(AMB)(0.03-1μg/mL).

ThisworkaimedtoevaluatetheantifungalactivityofPiroctoneolamineinthetreatmentofintra-abdominalcandidiasisinanexperimentalmodelusingSwissmice.ThetreatmentwithPiroctoneolamine(0.5mg/kg)isperformed72hafterinfectionbyintraperitonealadministration.Forcomparison,agroupofanimals(n=6)istreatedwithAmphotericinB(0.5mg/kg).ThemycologicaldiagChemicalbooknosisismadebycollectingtheliver,spleenandkidneys.DataregardingthefungalgrowthandmortalityareanalyzedstatisticallybyStudent’sttestandanalysisofvariance,withlevelofsignificancesetatP<0.05.Thedifferenceinfungalgrowthscoringbetweenthecontrolgroupandthetreatmentgroups(PiroctoneolamineandAmphotericinB)isstatisticallysignificant(P<0.05).

3. Main Efficacy

（1） Squalane: Strengthens the repair of the epidermis, effectively forms a natural protective film, and helps maintain the balance between the skin and sebum.

（2） Squalane is a lipid most similar to human sebum, with strong affinity. It can integrate with the human's own sebum film, forming a natural barrier on the skin surface.

（3） Squalane can also inhibit the peroxidation of skin lipids, effectively penetrate the skin, and promote the proliferation of basal skin cells. It has significant physiological effects in delaying skin aging, improving, and eliminating melasma.

（4） Squalane can also open up skin pores, promote blood microcirculation, enhance cellular metabolism, and assist in the repair of damaged cells.