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Adipotide, also known as FTPP or prohibitin-TP 01, is a synthetic pro-apoptotic peptidomimetic that has attracted much attention in the field of obesity research. Although often described as a peptide, it is actually made of small protein-like chains, which are used to mimic the properties of peptides.

Mechanism of Action

Adipotide has a unique mechanism of action, mainly reducing the number of adipocytes by targeting the blood supply of fat cells. It can specifically recognize and bind to a protein receptor called prohibitin on the blood vessel walls of adipose tissue. Once bound, it triggers a series of reactions, disrupting the blood supply to fat cells, causing them to undergo apoptosis (programmed death) due to lack of nutritional supply. Unlike other weight loss methods, it does not simply inhibit fat production or promote fat decomposition, but fundamentally reduces the number of fat cells. Moreover, this targeted effect is highly selective, only targeting the blood vessels of fat cells, with little impact on the blood vessels of other organs and tissues.

Research Data

1. Results of animal experiments: In rhesus monkey experiments, monkeys injected with Adipotide daily had a 20% reduction in stomach fat within 28 days, and some monkeys had a 39% reduction in total body fat. After four weeks of Adipotide injection followed by four weeks of no treatment, ten obese female rhesus monkeys lost an average of 11% of their body weight and 39% of their fat deposits, with most weight loss occurring during the non-treatment period. At the same time, monkeys treated with Adipotide not only lost weight but also had improved insulin sensitivity, which means it may have a positive effect on the control of type 2 diabetes. In addition, the monkeys' appetite also decreased, and their overall food intake was reduced.

2. Prospects for clinical application: Although Adipotide is still mainly in the research stage and has not been widely used in clinical practice, these encouraging results from animal experiments bring hope for its future application in the treatment of human obesity and the management of related metabolic diseases. If subsequent clinical studies can confirm its safety and effectiveness, Adipotide is expected to become an important innovative drug in the field of obesity treatment.

Product Parameters

• Chinese Name: Adipotide

• English Name: Adipotide

• CAS: 9002-72-6

• Purity Specification: Usually up to 98% and above

• Product Category: Peptidomimetic

• Molecular Formula: C111H204N36O28S2

• Molecular Weight: 2555.2g/mol

• Product Form: Generally lyophilized solid to ensure maximum stability and ease of use in research environments. It should be reconstituted and stored in accordance with relevant guidelines.

Potential Advantages

1. Significant weight loss effect: From the animal experiment data, it can effectively reduce fat mass and body weight, and its mechanism of action is relatively novel, which may have a more lasting effect compared with traditional weight loss methods.

2. Improving metabolic indicators: It improves insulin sensitivity, helps control blood sugar levels, may have potential benefits for diabetic patients, and may also have a positive impact on other metabolism-related indicators.

3. No psychological side effects: The process does not cause psychological symptoms, does not affect neurotransmitter regulation, and avoids emotional fluctuations, anxiety and other adverse reactions that some weight loss drugs may bring.

4. Precise targeting: It only targets the blood vessels of fat cells, has little impact on other normal tissues and organs of the body, and may have relatively good safety and tolerance.

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