Cancer Prevention effect with Broccoli seeds Extract Glucoraphanin

100% Natural Broccoli /Broccoli Seeds Extract Glucoraphani

What is Glucoraphanin  ?

 Glucoraphanin is a potent and long-lasting antioxidant primarily found in broccoli. However, sulforaphane levels vary considerably between individual broccoli plants, leaving consumers uncertain of its content when purchasing. What is certain is that this phytonutrient exists at significantly higher concentrations in broccoli seeds and in broccoli sprouts that are three days old.

Glucoraphanin (a glucosinolate) is the precursor to sulforaphane, a compound with natural anti-cancer properties, and is found in high concentrations in cruciferous vegetables, particularly broccoli. Its relative molecular mass is 436.499, with the molecular formula C ₁₂ H ₂₃ NO ₁₀ S ₃ .

In 2013, broccoli seed extract received US FDA approval (GRAS certification) for use as a food additive.

In 2017, China's National Health Commission approved broccoli seed aqueous extract (containing 13-20% glucoraphanin) as a novel food ingredient under Document No. 7 of 2017.

Consequently, broccoli seed aqueous extract was formally incorporated into the food ingredient database. This milestone signifies that glucoraphanin, possessing clinical nutritional value, may now be formally applied within China's food sector, thereby contributing to public health initiatives.

1.The Relationship Between Glucoraphanin and Sulforaphane

Glucoraphanin: A naturally occurring glucosinolate found in broccoli.

Sulforaphane: An isothiocyanate formed through enzymatic conversion of glucoraphanin, representing its biologically active form.

2.Biological Activity and Mechanism of Action

1. Activation of the Nrf2 Signalling Pathway:

Sulforaphane ranks among the most potent activators of Nrf2 (Nuclear Factor Erythroid 2-related Factor 2), initiating the body's cellular protection and detoxification responses.

2. Antioxidant and Anti-inflammatory Effects:

By activating Nrf2, sulforaphane promotes the production of antioxidant enzymes, combats oxidative damage, and exerts anti-inflammatory effects.

5. Anti-Cancer Effects:

Sulforaphane also induces phase II detoxification enzymes to eliminate carcinogens, thereby inhibiting cancer cell growth and metastasis to exert its anti-cancer effects.

3.Extraction Sources and Applications

1.Primary Sources:

Sulforaphane is present in cruciferous vegetables such as broccoli and cabbage, with particularly high concentrations found in broccoli seeds and sprouts.

2.Extraction Process:

Commercially, sulforaphane is primarily extracted from broccoli seeds, requiring advanced techniques including defatting, hydrolysis, and chromatographic purification.

3.Applications:

Due to its potent biological activity, sulforaphane has been developed into health products including dietary supplements and skincare formulations, enjoying widespread consumption in markets such as North America and Europe.