Calcium gluconate,CAS 299-28-5

Calcium gluconate is a mineral supplement, manufactured by the neutralization of gluconic acid with lime or calcium carbonate.
Odourless, white crystalline granules or powder, stable in air|WHITE SOLID IN VARIOUS FORMS.
Calcium gluconate is the calcium salt of D-gluconic acid. It has a role as a nutraceutical. It contains a D-gluconate.|Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated solution of calcium gluconate for intravenous use only. Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate. Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.|Calcium Gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. (NCI04)|The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

Calcium gluconate Use and Manufacturing
Methods of Manufacturing
Neutralization of gluconic acid with lime or calcium carbonate.|D-Glucose is oxidized to gluconic acid in the presence of calcium carbonate. The oxidation may be effected by certain molds, eg, Aspergillus niger, or by bromine.
Uses
1. As a food additive, used as a buffer; solidifying agent; chelating agent; nutritional supplement. According to the "Hygienic Standards for the Use of Food Nutritional Supplements" (1993) promulgated by the Ministry of Health, it can be used for cereals and their products and beverages. 2. As a medicine, it can reduce capillary permeability, increase density, maintain the normal excitability of nerves and muscles, strengthen myocardial contractility, and help bone formation. It is suitable for allergic diseases, such as urticaria; eczema; skin pruritus; contact dermatitis, and serum sickness; angioedema as an adjuvant treatment. It is also suitable for convulsions and magnesium poisoning caused by hypocalcemia. It is also used to prevent and treat calcium deficiency.