Product Introduction
Phloretin Powder is a plant polyphenol of dihydrochalcone, which can be extracted from apple and grapefruit peel and can protect plants from ultraviolet rays. For human skin, phloretin has strong antioxidant and photoprotective effects (can eliminate UV-induced increase in skin free radicals and damage to cells and DNA) and can inhibit matrix metalloproteinases (MMP-1). ) and elastase, enzymes that degrade the skin's connective tissue and play an important role in skin photoaging. The phloretin powder is extracted from the peel and root bark of juicy fruits such as apples and pears and is a kind of dihydrochalcone.
Feature
| 1. Anti-aging and antioxidant activity Studies have shown that the phenolic hydroxyl group in the structure of natural flavonoids can react with free radicals to generate stable semiquinone free radicals, thereby inhibiting lipid peroxidation at the initial stage and terminating the free radical chain reaction. Phloretin Powder is a flavonoid compound with a dihydrochalcone structure and has 4 phenolic hydroxyl groups. Its unique structure determines its strong antioxidant activity. In vitro experiments show that phloretin has the ability to inhibit mitochondrial lipid peroxidation and scavenge DPPH free radicals and ABTS free radicals. Studies have shown that phloretin has strong antioxidant activity, and its antioxidant mass concentration in oil is 10.30 mg/L, which can remove free radicals in the skin. Phloretin not only has an antioxidant effect by itself but also can be used in combination with existing antioxidants to improve the antioxidant effect. It can be seen that phloretin and its inclusion complex have a good effect of scavenging free radicals, and have great application prospects in anti-aging cosmetics.  2. Anti-inflammatory activity In vitro studies have shown that phloretin can inhibit the production of inflammatory factors, chemokines and differentiation factors, and has certain anti-inflammatory effects. At the same time, studies have found that phloretin can inhibit the phosphorylation of single Akt and MAPK, thereby achieving anti-inflammatory effects. In vivo studies have also demonstrated that phloretin has antioxidant and anti-inflammatory effects. The anti-inflammatory effects of phloretin in vitro and in vivo indicate that it has a potentially soothing effect and can be used in soothing skin care products.
3. Sun protection effect Studies have found that phloretin has a certain ultraviolet absorption capacity, adding phloretin to the basic formula of cosmetics can improve the SPF and SPA value of cosmetics. In addition, Phloretin, V and Ferulic Acid blend protect human skin from UV rays and provide photoprotection for human skin. Phloretin has antioxidant activity and absorbs ultraviolet rays, and has potential application value in sunscreen cosmetics.
4. Promote transdermal absorption Phloretin Powder is a lipophilic compound that penetrates the skin via intercellular lipids. Studies have shown that phloretin can affect the carrier-mediated transport process and has a certain function of promoting transdermal absorption. Phloretin is a natural, safe and effective lipophilic compound with certain. The penetration-promoting effect can be added to cosmetics as a carrier of effective active ingredients to promote the transdermal absorption of active ingredients so that they can exert better efficacy.  |
5. Bacteriostatic activity Phloretin is a flavonoid compound with antibacterial activity. In addition to its antibacterial activity against pathogenic bacteria, phloretin also has an effect on common skin bacteria. The MIC of phloretin on Propionibacterium acnes and P. acnes granules is 0.5 mg/L. At the same time, the results of clinical trials show that the whiteheads, blackheads, papules and sebum secretion of the subjects after using phloretin for 4 weeks were all reduced. There was a significant decrease, indicating that phloretin has a potential acne-relieving effect. Phloretin has a certain antibacterial effect. With in-depth research on the antibacterial effect of phloretin, phloretin may be developed as a new type of natural antibacterial agent and added to cosmetics to replace some chemical preservatives. It can be added to anti-acne cosmetics as a functional raw material.
6. Whitening activity Studies have found that phloretin has the effect of inhibiting tyrosinase activity and its inhibitory effect on tyrosinase is better than that of common whitening agents (kojic acid and arbutin). Further research has found that phloretin and common tyrosine combination of enzyme inhibitors can greatly increase its inhibition rate and well achieve a 100% inhibition effect. In addition, the inclusion complex of hydroxypropyl cyclodextrin and phloretin also has a good effect on inhibiting tyrosinase activity.
7. Moisturizing effect The 4 hydroxyl groups contained in the phloretin molecule can form hydrogen bonds with water molecules, absorb water, and have a potential moisturizing effect. Therefore, phloretin can also be used as a natural moisturizer in moisturizing cosmetics.
8. Anti-hair loss effect Studies have shown that phloretin can inhibit the activity of soybean lipoxygenase, thereby reducing hair loss due to premature aging, indicating that phloretin has a potential anti-hair loss effect and can be added to shampoos and hair care as an anti-hair loss raw material prime.
9. Promote membrane absorption Phloretin powder is a lipophilic compound that has a certain effect on the cell membrane and can affect the carrier-mediated transport process. Studies have shown that phloretin has the ability to inhibit the activity of melanocytes and has a lightning effect on various skin spots. It has a good inhibitory effect on tyrosinase and is a very safe and effective freckle-removing and whitening agent. In vitro, tyrosinase Activity experiments showed that the way phloretin inhibited tyrosinase activity was competitive inhibition in a dose-dependent manner.
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Phloretin Powder can be used in masks, creams, lotions and serums. Phloretin can inhibit the excessive secretion of sebaceous glands and is used to treat exuberant acne; it can inhibit the activity of melanocytes and has an effect on various skin pigmentation. Compared with similar natural ingredients arbutin and kojic acid, the same concentration of phloretin has a better inhibitory effect on tyrosinase, and when compounded with arbutin and/or kojic acid, it can greatly enhance the inhibition of tyrosinase. acids inhibition. Improve the inhibition rate of the product to tyrosinase, so that the inhibition rate reaches 100%.
Phloretin Powder has a strong moisturizing effect and can absorb 4 to 5 times its own weight in water. It can promote the absorption and utilization of other functional factors in the formula to make it play a better effect. It has strong antioxidant properties and can scavenge free radicals in the skin. The antioxidant concentration of the oil is between (10-30) × 10-6. It can prevent carbohydrates from entering epidermal cells, thereby inhibiting the excessive secretion of skin glands, and treating acne with strong secretion; it can inhibit the activity of melanocytes, and has a lightening effect on various skin pigmentation. Phloretin can be used in masks, creams, lotions and serums.
Cosmetic ▲Inhibit the effect of tyrosinase, lighten the spots and whiten the skin; ▲ Strong antioxidant capacity, can effectively delay skin wrinkles, aging and other aging symptoms ▲ It can prevent sugar components from entering epidermal cells ▲ Strong moisturizing effect. |
Health products ▲ Anti-oxidation and anti-free radical effects; ▲Anti-inflammatory and immunosuppressive effects. |
Flavors, Spices ▲Inhibit bitterness and other unpleasant tastes in food and improve taste; ▲ Reduce the odor of high-intensity sweeteners and cover up bad flavors; ▲Use stevia as a taste regulator. |
Product Name | Phloretin | Botanical Source | Malus pumila Mill. |
CAS No. | 60-82-2 | Plant Part | Branch |
ITEM | SPECIFICATION | RESULT | TEST METHOD |
Physical Description |
Appearance | Off White Powder | Conforms | Visual |
Odor | Characteristic | Conforms | Organoleptic |
Taste | Characteristic | Conforms | Olfactory |
Particle size | 95% pass through 80 mesh sieve | Conforms | CP2020 |
Chemical Tests |
Assay | ≥98.0% | 98.53% | HPLC |
Loss on drying | ≤1.0% | 0.38% | CP2020 |
Ash | ≤1.0 % | 0.10% | CP2020 |
Heavy Metals | ≤10 ppm | Conforms | CP2020 |
Lead (Pb) | ≤2ppm | Conforms | CP2020(AAS) |
Arsenic (As) | ≤1ppm | Conforms | CP2020(AAS) |
Cadmium (Cd) | ≤2 ppm | Conforms | CP2020(AAS) |
Mercury (Hg) | ≤1ppm | Conforms | CP2020(AAS) |
Microbiology Control |
Aerobic bacterial count | ≤1,000 cfu/g | Conforms | CP2020 |
Total Yeast & Mold | ≤100 cfu/g | Conforms | CP2020 |
Escherichia coli. | Negative | Conforms | CP2020 |
Salmonella | Negative | Conforms | CP2020 |
Conclusion | Conforms to specification |
Storage: | Store in tightly sealed and preferably full containers in cool, dry and ventilated area. |
Shelf Life | 24 months when properly stored. |
Status: | Non-irradiation; Non-GMO; No Carrier; Halal & Kosher certified. |
Security statement：
Our company guarantees that the goods sent are safe, non-flammable and explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.
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