Quinolinic acid RC01271
89-00-9
Industrial Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceQuinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
DryPowder|Solid
Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a human metabolite, a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a quinolinate(1-) and a quinolinate.|Quinolinic Acid is an intermediate product of the kynurenine pathway, which is responsible for the conversion of the amino acid tryptophan into nicotinamide adenine dinucleotide, with potential neurotoxic activity. If produced in excess, quinolinic acid can cross the blood-brain barrier (BBB) and function as an N-methyl-D-aspartate (NMDA) receptor agonist, which may lead to both neuronal damage and neurodegenerative brain disease. The NMDA receptor, a heterotetrameric, ligand-gated and voltage-dependent glutamate receptor, is critical for synaptic plasticity, learning and memory.|A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.Basic Info-
Product Name:
Quinolinic acid
Other Name:2,3-Pyridinedicarboxylic acid;Quinolinic acid;NSC 13127;NSC 18836;NSC 403247
CAS No.:89-00-9
Molecular Formula:C7H5NO4
InChIKeys:InChIKey=GJAWHXHKYYXBSV-UHFFFAOYSA-N
Molecular Weight:173.17
Exact Mass:167.12
BRN:137110
EC Number:201-874-8
UNII:F6F0HK1URN
NSC Number:403247|18836|13127
DSSTox ID:DTXSID8041327
NCI Thesaurus Code:C113236
Color/Form:Crystals|Monoclinic crystals from water
HScode:29333999
Categories:
Characteristics-
PSA:
87.5
XLogP3:0.2
Appearance:White to light yellow-beige Crystalline Powder
Density:1.6±0.1 g/cm3
Melting Point:228.5 °C
Boiling Point:425ºC at 760 mmHg
Flash Point:210.9±24.6 °C
Refractive Index:1.628
Water Solubility:H2O: 0.55 g/100 mL
Storage Conditions:Store at RT
Vapor Pressure:6.1X10-6 mm Hg at 25 °C (est)
Odor:Odorless
PKA:2.43None
Henrys Law Constant:Henry's Law constant = 2.86X10-15 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 2.43 (conjugate acid)|pKa2 = 5.48 (est)
Collision Cross Section:130.5 Ų [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|138.98 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|130.03 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|132.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|126.6 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|130.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|128 Ų [M-H]-
Experimental Properties:190 °C when rapidly heated, with decomposition into CO2 and nicotinic acid|Hydroxyl radical reaction rate constant = 1.08X10-12 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
