intermediate used in the synthesis of the anticoagulant drug Apixaban 545445-44-2

Our company sells more than 5 tons of Apixaban Intermediate to domestic export trading companies every year.
In recent years, we have started to do foreign market. Please contact me to obtain the factory price.

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester					503614-91-3	Apixaban intermediate
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester					27143-07-3	Apixaban intermediate
2(1H)-pyridine,3-chloro-5,6-dihydro-1-(4-nitrophenyl)					536760-29-9	Apixaban intermediate
3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one					545445-44-1	Apixaban intermediate
3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone					503615-03-0	Apixaban intermediate
Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3					536759-91-8	Apixaban intermediate
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate					503615-07-4	Apixaban intermediate
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone					1267610-26-3	Apixaban intermediate

Apixaban is an anticoagulant used to reduce the risk of stroke and systemic embolism in patients with non valvular atrial fibrillation. 
A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development

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NATURE INDUSTRIAL LIMITED is a chemical company located in Jinan, Shandong Provincin Hongkong, China. The company was established in 20111 and has since grown to become a leading manufacturer and supplier of pharmaceutical intermediates, APIs, and other fine chemicals.

Quality is of the utmost importance to us The company has implemented a strict quality control system to ensure that all of its products meet or exceed the highest international standards. The company's quality control department is responsible for testing and analyzing each batch of products to ensure that they are of the highest quality.

NATURE INDUSTRIAL LIMITED is committed to environmental protection and sustainability. The company has implemented a comprehensive environmental management system that is in compliance with ISO 14001 standards. The company's production processes are designed to minimize waste and reduce the use of energy and other resources.

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