Nimustine hydrochloride CAS:55661-38-6
GMP ISO
55661-38-6
Pharmaceutical Grade
99%
Shenzhen
25kg 100kg 1000kg
2025-12-13
Pharmaceutical intermediate/API， and fragrances API
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceNimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3].
Nimustine hydrochloride is a hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors. It has a role as an antineoplastic agent. It contains a nimustine(1+).|Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.|Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
ChEBI: A hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors.CertificatesBasic Info-
Product Name:
Nimustine hydrochloride
Other Name:1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE;ACNU;Nimustine HCl(ACNU);NIMUSTINE HCL;NIMUSTINE HYDROCHLORIDE;N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLOROETHYL)-N-NITROSOUREA HYDROCHLORIDE;1-(2-cloroetil)-1-nitroso-3-((2-metil-4-aminopirimidin-5-il)metil)ureaclorhi;1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoureahydr
CAS No.:55661-38-6
Molecular Formula:C9H14Cl2N6O2
InChIKeys:InChIKey=KPMKNHGAPDCYLP-UHFFFAOYSA-N
Molecular Weight:309.15
Exact Mass:308.055542
EC Number:678-313-2
UNII:DFR965WKBU
NSC Number:245382
DSSTox ID:DTXSID80204185
NCI Thesaurus Code:C95325
Color/Form:White to Light yellow
HScode:2933.59.8000
Categories:
Characteristics-
PSA:
114
XLogP3:2.57310
Melting Point:186°C(lit.)
Toxicity:LD50 in mice, rats (mg/kg): 62, 46 i.v. (Masuda)
Flammability characteristics:Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes
PH:3.0～4.5 (5g/l, 25℃)
Critical Temperature & Pressure:under inert gas (nitrogen or Argon) at 2–8 °C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediate/API， and fragrances API
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Location:
Building B, Sniff Titanium Workshop, No. 26 Shucheng Road, Hongshan District，Wuhan
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Payment Terms:
100% TT in advance
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
5-10
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Year of Establishment:
2020
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