Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)
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![Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/c5c861ff31d5454ea00fc07f725d0470.png "Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)")
Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)
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CAS No:
55661-38-6
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Formula:
C9H13ClN6O2.ClH
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Chemical Name:
Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)
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Synonyms:
Urea,N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-,hydrochloride (1:1);Urea,N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-,monohydrochloride;ACNU;Nimustine hydrochloride;NSC-D 245382;1-(4-Amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride;Nidran;52208-23-8
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CAS No:
Description
Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3].
Nimustine hydrochloride is a hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors. It has a role as an antineoplastic agent. It contains a nimustine(1+).|Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.|Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1) Basic Attributes
309.15
308.055542
1312995-182-4
DFR965WKBU
245382
DTXSID80204185
C95325
Characteristics
114
2.57310
186°C(lit.)
Oral-rat LD50: 113 mg/kg; Oral-Mouse LD50: 83 mg/kg
Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes
Safety Information
Ⅲ
6.1
UN 2811
25
36/37/39-45
YR8450000
T
Warehouse ventilated, low temperature and dry
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
ACNU
Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1) Use and Manufacturing
It has anti-tumor effect, it can degrade the DNA in the cells and inhibit the synthesis of DNA and RNA
Computed Properties
Molecular Weight:309.15
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:308.0555291
Monoisotopic Mass:308.0555291
Topological Polar Surface Area:114
Heavy Atom Count:19
Complexity:292
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific description provided
Registered Holders
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Fresenius Kabi (Wuhan) Pharmaceutical Co., Ltd.
Active
China
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Shandong Ruiying Pioneer Pharmaceutical Co., Ltd.
Active
China
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Hainan Huluwa Pharmaceutical Group Co., Ltd.
Active
China
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Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)
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