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Nimustine hydrochloride

Nimustine hydrochloride structure

CAS No:
55661-38-6
Formula:
C9H14Cl2N6O2
Chemical Name:
Nimustine hydrochloride
Synonyms:
1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE;ACNU;Nimustine HCl(ACNU);NIMUSTINE HCL;NIMUSTINE HYDROCHLORIDE;N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLOROETHYL)-N-NITROSOUREA HYDROCHLORIDE;1-(2-cloroetil)-1-nitroso-3-((2-metil-4-aminopirimidin-5-il)metil)ureaclorhi;1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoureahydr
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3].

Nimustine hydrochloride is a hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors. It has a role as an antineoplastic agent. It contains a nimustine(1+).|Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.|Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

ChEBI: A hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors.

Nimustine hydrochloride Basic Attributes

Molecular Weight：

309.15

Exact Mass：

308.055542

EC Number：

678-313-2

UNII：

DFR965WKBU

NSC Number：

245382

DSSTox ID：

DTXSID80204185

NCI Thesaurus Code：

C95325

Color/Form：

White to Light yellow

HScode：

2933.59.8000

Characteristics

PSA：

114

XLogP3：

2.57310

Melting Point：

186°C(lit.)

Toxicity：

LD50 in mice, rats (mg/kg): 62, 46 i.v. (Masuda)

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

PH：

3.0～4.5 (5g/l, 25℃)

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2–8 °C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811

hazard class code：

safety instructions：

36/37/39-45

RTECS Number：

YR8450000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P301 + P310

Hazard Statements：

RIDADR：

UN 2811

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

ACNU

Nimustine hydrochloride Use and Manufacturing

It has anti-tumor effect, it can degrade the DNA in the cells and inhibit the synthesis of DNA and RNA

Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.

Computed Properties

Molecular Weight:309.15
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:308.0555291
Monoisotopic Mass:308.0555291
Topological Polar Surface Area:114
Heavy Atom Count:19
Complexity:292
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific description provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Nimustine hydrochloride

Nimustine Hydrochloride for Injection
Ingredients	Nimustine hydrochloride
Indication	When used in combination with other anti-tumor agents or radiation, it may aggravate the suppression of bone marrow function.
Specifications	25mg (based on nimustine hydrochloride)
Manufacturer	Beijing SL Pharmaceutical Co., Ltd.

Nimustine Hydrochloride for Injection
Specifications	25mg

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Registered Holders

Fresenius Kabi (Wuhan) Pharmaceutical Co., Ltd.

China
Active
Shandong Ruiying Pioneer Pharmaceutical Co., Ltd.

China
Active
Hainan Huluwa Pharmaceutical Group Co., Ltd.

China
Active

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Nimustine hydrochloride CAS:55661-38-6

CAS No.: 55661-38-6

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Content: 99%

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