Deferoxamine RC03491
70-51-9
Pharmaceutical Grade
99%
Royalchem
25kg/drum
2030-01-01
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSolid
Solid
Desferrioxamine B is an acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. It has a role as an iron chelator, a siderophore, a ferroptosis inhibitor and a bacterial metabolite. It is a conjugate acid of a desferrioxamine B(3-).|Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.|Deferoxamine is an Iron Chelator. The mechanism of action of deferoxamine is as an Iron Chelating Activity.|Deferoxamine is a parenterally administered iron chelating agent used to treat transfusion related chronic iron overload. Deferoxamine rarely causes serum aminotransferase elevations during therapy and has not been convincingly linked to instances of clinically apparent liver injury.|Deferoxamine is an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)Basic Info-
Product Name:
Deferoxamine
Other Name:Butanediamide,N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-;Propionohydroxamic acid,N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-;Butanediamide,N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-;N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide;N-[5-[3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic acid;30-Amino-3,14,25-trihydroxy-3,9,14,20,25 pentaazatriacontane-2,10,13,21,24-pentaone;3,9,14,20,25-Pentaazatriacontane-2,10,13,21,24-pentone,30-amino-3,14,25-trihydroxy-;Deferoxamine B;Deferoxamine;Deferrioxamine B;Deferrioxamine;Desferrin;Desferrioxamine B;Desferrioxamine;Deferoxamin;Desferan;Desferex;Desferin;Deferriferrioxamine B;Desferioxamine B;NSC 527604;Desferoxime;DFO;N′-[5-[Acetyl(hydroxy)amino]pentyl]-N-7-[5-([4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl]amino)pentyl]-N-hydroxysuccinamide;DFO-B;7278-84-4
CAS No.:70-51-9
Molecular Formula:C25H48N6O8
InChIKeys:InChIKey=UBQYURCVBFRUQT-UHFFFAOYSA-N
Molecular Weight:560.68
Exact Mass:560.68
EC Number:200-738-5
UNII:J06Y7MXW4D
NSC Number:527604
DSSTox ID:DTXSID7022887
NCI Thesaurus Code:C416
ATC Code:V03AC01|V - Various
HScode:2924199090
Categories:
Characteristics-
PSA:
206
XLogP3:-2.2
Appearance:Solid
Density:1.212g/cm3
Melting Point:140 °C
Boiling Point:627.9°C (rough estimate)
Refractive Index:1.537
Water Solubility:9.90e-02 g/L
Toxicity:LD50 oral in mouse: 1340mg/kg
Experimental Properties:CRYSTALS FROM DIL ALC /MONOHYDRATE/|CRYSTALS FROM SLIGHTLY ACIDIC METHANOL /HYDROCHLORIDE/|CRYSTALS FROM DIL ALC /METHANESULFONATE/|CRYSTALS FROM N-PROPANOL /N-ACETYL DERIV/
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H317 May cause an allergic skin reaction
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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