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4-Methyl-2-pentanone 108-10-1

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CAS No.:

108-10-1

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

4-Methyl-2-pentanone Basic information

Product Name:	4-Methyl-2-pentanone
Synonyms:	4-METHYL-2-PENTANONE, FOR GC;4-METHYL-2-PENTANONE >=98.5% A.C.S. R&;4-METHYL-2-PENTANONE 99+% FCC;4-METHYL-2-PENTANONE, >=98.5%, A.C.S. REAGENT;METHYL ISOBUTYL KETONE GC STANDARD;Methyl-Iso-ButylKetoneGr;MethylIsobutylKetoneAcs;Methyl-Iso-ButylKetone(Iso-ButylMethylKetone)
CAS:	108-10-1
MF:	C6H12O
MW:	100.16
EINECS:	203-550-1
Product Categories:	ketone;ACS and Reagent Grade Solvents;Carbon Steel Cans with NPT Threads;Nutrition Research;Phytochemicals by Plant (Food/Spice/Herb);ReagentPlus;ReagentPlus Solvent Grade Products;Semi-Bulk Solvents;Zingiber officinale (Ginger);Amber Glass Bottles;Analytical Reagents;Analytical/Chromatography;CHROMASOLV for HPLC;Chromatography Reagents &;HPLC &;HPLC Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;UHPLC Solvents (CHROMASOLV);108-10-1;bc0001
Mol File:	108-10-1.mol

4-Methyl-2-pentanone Chemical Properties

Melting point	-80 °C (lit.)
Boiling point	117-118 °C
density	0.801 g/mL at 25 °C (lit.)
vapor density	3.5 (vs air)
vapor pressure	15 mm Hg ( 20 °C)
refractive index	n20/D 1.395(lit.)
FEMA	2731 \| 4-METHYL-2-PENTANONE
Fp	56 °F
storage temp.	Store at +5°C to +30°C.
solubility	water: soluble20g/L, soluble in alcohol, miscible with oils. Soluble in Propylene glycol and Glycerin.
form	Liquid
color	APHA: ≤15
Specific Gravity	0.80
Odor	Pleasant; mild, characteristic; sharp; non-residual; ketonic.
PH	7 (20°C)
Odor Threshold	0.17ppm
Odor Type	green
biological source	synthetic
explosive limit	1.2-8%, 93°F
Water Solubility	17 g/L (20 ºC)
λmax	λ: 335 nm Amax: 1.00 λ: 340 nm Amax: 0.50 λ: 360 nm Amax: 0.15 λ: 380 nm Amax: 0.02 λ: 400 nm Amax: 0.01
Merck	14,5207
JECFA Number	301
BRN	605399
Henry's Law Constant	2.56 at 25 °C (batch stripping method-GC, Kim et al., 2000)
Exposure limits	TLV-TWA 205 mg/m³ (50 ppm); STEL 300 mg/m³ (75 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).
Dielectric constant	13.0（Ambient）
Stability:	Volatile
LogP	1.3-1.9 at 20℃
CAS DataBase Reference	108-10-1(CAS DataBase Reference)
NIST Chemistry Reference	Methyl isobutyl ketone(108-10-1)
IARC	2B (Vol. 101) 2013
EPA Substance Registry System	Methyl isobutyl ketone (108-10-1)
ECETOC JACC REPORT	4-Methyl-2-pentanone (108-10-1)

Safety Information

Hazard Codes	F,Xn,T
Risk Statements	11-20-36/37-66-39/23/24/25-23/24/25
Safety Statements	9-16-29-45-36/37-7
OEB	A
OEL	TWA: 50 ppm (205 mg/m3), STEL: 75 ppm (300 mg/m3)
RIDADR	UN 1245 3/PG 2
WGK Germany	1
RTECS	SA9275000
Autoignition Temperature	840 °F
TSCA	Yes
HS Code	2914 13 00
HazardClass	3
PackingGroup	II
Hazardous Substances Data	108-10-1(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 2.08 g/kg (Smyth)
IDLA	500 ppm

4-Methyl-2-pentanone Usage And Synthesis

Description	4-Methyl-2-pentanone has a pleasant odor. May be prepared by hydrogenation of mesityl oxide over Ni at 160 - 190°C; also by oxidation of methyl isobutyl carbinol.
Chemical Properties	4-Methyl-2-pentanone has a fruity, ethereal, spicy (on dilution) odor.
Chemical Properties	4-Methyl-2-pentanone, also known as Methyl isobutyl ketone (MIBK), is a colorless liquid with a pleasant, sweet, fruity odor. The odor threshold can be as low as 0.10 ppm. It is 2% soluble in water by weight and with several other organic solvents. The lower explosive limit is 1.2% and the upper explosive limit is 8.0% at 200 °F. Methyl isobutyl ketone may be incompatible with strong oxidizers and potassium tert-butoxide.
Physical properties	Clear, colorless, watery liquid with a mild, pleasant odor. Odor threshold concentration is 47 ppb_v (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m³ (100 ppb_v) and 1.1 mg/m³ (270 ppb_v), respectively (Hellman and Small, 1974).
Occurrence	Reported found in orange and lemon juice, grape; vinegar, baked potato, papaya, ginger, wheat bread, cheeses, milk, cooked egg, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushroom, trassi, sesame seed, buckwheat, wort, elder flower, Bourbon vanilla, clary and red sage, crab, clam and Chinese quince.
Uses	MIBK is used as a solvent for gums, resins,nitrocellulose and cellulose ethers, and various fats, oils, and waxes.
Uses	In paints, glues, and cleaning agents; used in the plastic and petrol industries
Uses	Methyl isobutyl ketone (hexone, isobutyl methyl ketone, 4-methyl-2-pentanone) is an organic solvent similar in structure and use to methyl butyl ketone. In addition to its use as a solvent for paints, lacquers, and varnishes, methyl isobutyl ketone is used in extraction processes and as a denaturant for rubbing alcohol. Methyl isobutyl ketone is also used as a synthetic flavoring in some varieties of rum, candy, and cheese. Unlike methyl butyl ketone, methyl isobutyl ketone has not been found to occur naturally.
Definition	ChEBI: Methyl isobutyl ketone is a ketone.
Preparation	By hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.
Production Methods	Methyl isobutyl ketone can be manufactured by two processes . The first is a mixed ketone process where MiBK, diisobutyl ketone, and acetone are coproduced in a single reaction using isopropanol as a starting material. The second method is used to produce the majority of MiBK and involves a three-step reaction sequence in which diacetone alcohol and mesityl oxide are formed as intermediates.
Aroma threshold values	Detection: 240 to 640 ppb
Taste threshold values	Taste characteristics at 25 ppm: sweet, ethereal, banana and fruity with dairy nuances
Synthesis Reference(s)	Journal of the American Chemical Society, 100, p. 5437, 1978 DOI: 10.1021/ja00485a031 Tetrahedron Letters, 36, p. 2285, 1995 DOI: 10.1016/0040-4039(95)00191-E Tetrahedron, 37, p. 3073, 1981 DOI: 10.1016/S0040-4020(01)98839-8
General Description	A clear colorless liquid with a pleasant odor. Flash point 73°F. Less dense than water. Vapors heavier than air.
Air & Water Reactions	Highly flammable. 4-Methyl-2-pentanone is sensitive to air (may form explosive peroxides). Slightly soluble in water.
Reactivity Profile	4-Methyl-2-pentanone is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. 4-Methyl-2-pentanone reacts violently with potassium tert-butoxide. 4-Methyl-2-pentanone reacts vigorously with reducing materials. .
Hazard	Flammable, dangerous fire risk, explosivelimits in air 1.4–7.5%. Avoid ingestion and inhala-tion. Upper respiratory tract irritant, dizziness, andheadache. Possible carcinogen.
Health Hazard	Vapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them.
Health Hazard	MIBK exhibits low to moderate toxicity.It is more toxic than acetone. Exposureto 200 ppm can cause irritation of theeyes, mucous membranes, and skin. Prolonged skin contact can leach out fat fromthe skin. Exposure to high concentrationscan cause nausea, headache, and narcosis. Animal studies indicate that this compound could probably cause kidney damage,with symptoms of a heavier kidney, higherkidney-to-body weight ratio, and tubularnecrosis. An increase in liver weight wasnoted, too, associated with its exposure inanimal subjects. In male rats the effect wasobserved at 2000 ppm on 2 weeks’ exposure(6 hours/day) (Phillips et al. 1987). Otherthan for the male rat kidney effect, the levelsup to 1000 ppm for 14 weeks had no significant toxicological effect. In another study,exposure to 3000 ppm in rats and mice wasfound to cause increased liver and kidneyweights, decrease in food consumption, incidence of dead fetuses, and reduced fetal bodyweight (Tyl et al. 1987). Ingestion of MIBK can result in narcosis and coma. A genetic toxicology studyof MIBK showed a negative response inthe bacterial mutation assays and the yeastmitotic gene conversion assay (Brooks et al.1988). LD50 value, oral (rat): 2080 mg/kg LD50 value, intraperitoneal (rat): 400 mg/kg.
Flammability and Explosibility	Highly flammable
Chemical Reactivity	Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Potential Exposure	MIBK is used as a solvent; a denaturant; and as an extractant; in the manufacture of methyl amyl alcohol; as a solvent in paints, varnishes, and lacquers; as an alcohol denaturant; as a solvent in uranium extraction from fission products.
First aid	If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Carcinogenicity	The National Toxicology Program conducted cancer bioassays by exposing groups of 50 male and 50 female F344 rats and B6C3F1 mice to MiBK vapor at 0, 450, 900, or 1800 ppm 6h/day, 5 days/ week for 2 years. Survival and body weight gain were decreased in male rats at 1800 ppm. Body weight gain was also decreased in male rats at 900 and in female mice at 1800ppm. A higher incidence of mineralization of the renal papilla was observed in male rats at all MiBK exposure levels. Chronic progressive nephropathy (CPN) and the incidences of adenoma and adenoma or carcinoma (combined) were increased for the male 1800 ppm exposure group. The severity of CPN and renal tubular hyperplasia was increased in all male rat exposure groups. An uncertain increase in mononuclear cell leukemia, adrenal medulla hyperplasia, and a positive trend for increases in benign or malignant pheochromocytomas (combined) were reported for the 1800 ppm male group. The NTP considered that there was some evidence of carcinogenic activity in male rats based on increased incidences of renal tubule neoplasms. None of the rodent bioassay results were considered clear evidence of carcinogenicity by NTP.

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Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer, etc.

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Methyl isobutyl ketone

Other Name:

2-Pentanone,4-methyl-;4-Methyl-2-pentanone;Isobutyl methyl ketone;Methyl isobutyl ketone;2-Methyl-4-pentanone;MIBK;MIK;Hexone;4-Methyl-2-oxopentane;Isopropylacetone;2-Methylpropyl methyl ketone;Methyl iso-butyl ketone;Methyl 2-methylpropyl ketone;NSC 5712;ZMD-D;1338234-91-5

CAS No.:

108-10-1

UN No.:

1245

Molecular Formula:

C6H12O

InChIKeys:

InChIKey=NTIZESTWPVYFNL-UHFFFAOYSA-N

Molecular Weight:

100.161

Exact Mass:

100.16

EC Number:

203-550-1

HScode:

2914 13 00

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

17.1

XLogP3:

1.38

Appearance:

Clear liquid

Density:

0.8042 g/cm³ @ Temp: 20 °C

Melting Point:

-85 °C

Boiling Point:

115.8 °C @ Press: 760 Torr

Flash Point:

64°F

Refractive Index:

n 20/D 1.395(lit.)

Water Solubility:

water: soluble 20g/L

Storage Conditions:

Conditions that could lead to autoxidation (presence of air, light, heat, or heavy metals) or condensation (strongly acidic or basic media) should be avoided during storage. Containers of V2A steel are recommended for both storage and transportation.

Vapor Pressure:

Vapour pressure, kPa at 20°C: 2.1

Vapor Density:

3.45

Toxicity:

LD50 orally in rats: 2.08 g/kg (Smyth)

Flammability characteristics:

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

Explosive limit:

vol% in air: 1.4.5

See More Methyl isobutyl ketone Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P319 Get medical help if you feel unwell.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants. Well closed.... OPEN LIGHTS OR OTHER AGENCIES LIABLE TO IGNITE THE VAPOR SHOULD BE EXCLUDED FROM THOSE AREAS WHERE LIQUID IS BEING STORED OR USED. KETONES

See More Methyl isobutyl ketone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

27 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Mibk 100% Powder	1000 MT	Sep 6, 2023
Saudi Arabia	Methyl Isobutyl Ketone	100 MT	Jan 16, 2026
India	Methyl isobutyl ketone	18 MT	Dec 3, 2025
India	Methyl Isobutyl Ketone	24 MT	Jul 23, 2025
India	MIBK	10.00 MT	Jun 13, 2024
South Korea	Methyl Isobutyl Ketone	1 20' Fcl	May 17, 2024
South Korea	MIBK	3 20' Fcl	Dec 29, 2023
India	Mibk	1.00 20' Fcl	Sep 18, 2023
India	Mibk 100% White Powder	1000 MT	Aug 28, 2023
Brazil	MIBK METHYL ISOBUTYL KETONE KOREA KUMHO	500000 KG	Jul 26, 2023
Bangladesh	MIBK	1 20' Fcl	Dec 31, 2025
Pakistan	Methyl Isobutyl Ketone (MIBK)	1.00 20' Fcl	Dec 15, 2025
Bangladesh	Methyl Isobutyl Ketone	40 MT	Aug 26, 2025
India	Methyl Isobutyl Ketone	18 MT	Jul 16, 2025
Greece	MIBK	1 20' Fcl	Apr 17, 2025
Jordan	MIBK	1000 KG	Mar 24, 2025
India	methyl isobutyl ketone	2.00 MT	Feb 26, 2025
India	METHYL ISOBUTYL KETONE	5 20' Fcl	Feb 6, 2025
India	Methyl isobutyl ketone	500.00 MT	Jun 24, 2024
India	Methyl isobutyl ketone	1.00 MT	Apr 11, 2024

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4-Methyl-2-pentanone 108-10-1

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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