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p-Coumaric acid501-98-4

Name: p-Coumaric acid501-98-4
Brand: OORENT
SKU: pr2610121020
Price: 33 USD
Availability: InStock

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CAS No.:

501-98-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-12

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Product Detailv

p-Coumaric acid Basic information

Product Name:	p-Coumaric acid
Synonyms:	(e)-3-(4-hydroxyphenyl)-2-propenoicacid;AKOS BAR-2479;AKOS 221-47;COUMARIC ACID, TRANS-P-;RARECHEM BK HW 0163;PHCA;P-HYDROXYL CINNAMIC ACID;P-COUMARIC ACID
CAS:	501-98-4
MF:	C9H8O3
MW:	164.16
EINECS:	610-511-6
Product Categories:	Antioxidant;Auxins;Aromatic Cinnamic Acids, Esters and Derivatives;Biochemistry;Plant Growth Regulators;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;501-98-4;OLED;VX:15169101773
Mol File:	501-98-4.mol

p-Coumaric acid Chemical Properties

Melting point	214 °C (dec.)(lit.)
Boiling point	231.61°C (rough estimate)
density	1.1403 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	ethanol: soluble50mg/mL
form	Powder
pka	4.65±0.10(Predicted)
color	Off-white to beige or greenish
Odor	at 100.00%. balsamic
Water Solubility	soluble
Merck	14,2560
BRN	2207383
Henry's Law Constant	7.2×10⁵ mol/(m³Pa) at 25℃, Abraham and Jr. (2019)
Stability:	Light Sensitive
Major Application	food and beverages
InChI	1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChIKey	NGSWKAQJJWESNS-ZZXKWVIFSA-N
SMILES	OC(=O)\C=C\c1ccc(O)cc1
LogP	1.460
CAS DataBase Reference	501-98-4(CAS DataBase Reference)
NIST Chemistry Reference	p-Hydroxycinnamic acid(501-98-4)
EPA Substance Registry System	2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	2
RTECS	GD9095000
HS Code	29163990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
4-Hydroxycinnamic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

p-Coumaric acid Usage And Synthesis

Chemical Properties	Off-white to beige or greenish powder. Soluble in alcohol, ether and hot water, slightly soluble in benzene, insoluble in petroleum ether.
Uses	trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Stud ies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines.
Definition	ChEBI: p-coumaric acid is the trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.
Application	trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. It has been used as a component of chemiluminescent substrate for protein detection in western blotting.
Preparation	Synthesis of p-Coumaric acid: take o-acetylsalicyloyl chloride as raw material, in the presence of magnesium chloride, react with diethyl malonate in acetonitrile solvent, then add triethylamine, and react at 0°C for 1 h to obtain ( 2-acetoxybenzoyl) diethyl malonate product, then heated to 50°C in potassium hydroxide/methanol solution, reacted for 3h, and cyclized to obtain p-Coumaric acid.
Biochem/physiol Actions	p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate. Hydroxycinnamic acid found in many fruits and vegetables.
Anticancer Research	p-Coumaric acid can exert anticancer activity by different mechanisms: modulating inflammation and oxidative stress, inducing apoptosis, halting cell cycle progression, altering cellular proliferation pathways, and enhancing sensitivity to chemotherapeutic drugs^[1].
in vivo	In vivo studies showed that p-Coumaric acid (p-CouA) could be absorbed via the stomach, jejunum, ileum, and colon. Moreover, p-CouA is much more bioavailable than caffeic, ferulic, rosmarinic, and chlorogenic acids. Similarly, another study using the gastrointestinal sac technique demonstrated that p-CouA might be absorbed in all parts of the gastrointestinal tract, with the highest absorption rate in the jejunum^[1].
Purification Methods	Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.]
References	[1] Tehami, W., Nani, A., Khan, N. A., & Hichami, A. (2023). New Insights Into the Anticancer Effects of p-Coumaric Acid: Focus on Colorectal Cancer. 21 1, 15593258221150704. https://doi.org/10.1177/15593258221150704

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ECHEMI Editorial Reference

p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
Solid
4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.

Basic Info

Product Name:

trans-4-Hydroxycinnamic acid

Other Name:

2-Propenoic acid,3-(4-hydroxyphenyl)-,(2E)-;Cinnamic acid,p-hydroxy-,(E)-;2-Propenoic acid,3-(4-hydroxyphenyl)-,(E)-;(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid;Naringeninic acid;trans-p-Coumaric acid;(E)-p-Coumaric acid;trans-p-Hydroxycinnamic acid;(E)-p-Hydroxycinnamic acid;trans-4-Hydroxycinnamic acid;p-Hydroxy-trans-cinnamic acid;(E)-3-(4-Hydroxyphenyl)-2-propenoic acid;trans-4-Coumaric acid;p-trans-Coumaric acid;(E)-4-Hydroxycinnamic acid;trans-3-(4-Hydroxyphenyl)-2-propenoic acid;(E)-3-(4-Hydroxyphenyl)acrylic acid;trans-p-Coumarinic acid;(2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid;(E)-3-(4-Hydroxyphenyl)acrylic acid

CAS No.:

501-98-4

Molecular Formula:

C9H8O3

InChIKeys:

InChIKey=NGSWKAQJJWESNS-ZZXKWVIFSA-N

Molecular Weight:

164.16

Exact Mass:

164.16

BRN:

2207383

EC Number:

231-000-0

UNII:

IBS9D1EU3J

NSC Number:

674321|59260

DSSTox ID:

DTXSID6064660

HScode:

2918290000

Categories:

Insecticides

Characteristics

PSA:

57.5

XLogP3:

1.5

Appearance:

Off-white to beige or greenish Powder

Density:

1.3±0.1 g/cm3

Melting Point:

214 °C (decomp)

Boiling Point:

329.3°C at 760 mmHg

Flash Point:

177.3±17.4 °C

Refractive Index:

1.660

Water Solubility:

H2O: soluble ;ethanol: soluble 50mg/mL

Storage Conditions:

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Collision Cross Section:

127 Å² [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|129.27 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|131.1 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|131.3 Å² [M-H]-

See More trans-4-Hydroxycinnamic acid Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More trans-4-Hydroxycinnamic acid Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	trans-4-Hydroxycinnamic acid	100 G	Oct 11, 2026

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p-Coumaric acid501-98-4

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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