Ben-4(Benzophenone-4) ,CAS 4065-45-6

Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light.
DryPowder
Sulisobenzone is a member of benzophenones.|Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations. It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage. The UV-filter substance, sulisobenzone (BP-4) is widely used an ingredient in sunscreens and other personal care products,. It falls under the drug category of benzophenones. The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. Benzophenones may be found organically in fruits such as grapes. Benzophenones are used as photoinitiators, fragrance enhancers, ultraviolet curing agents, and, occasionally, as flavor ingredients; they are also used in the manufacture of insecticides, agricultural chemicals, and pharmaceuticals and as an additive for plastics, coatings, and adhesives. As a group, benzophenones may be used to delay photodegradation or extend shelf life in toiletries and plastic surface coatings.

Benzophenone 4 Use and Manufacturing

Methods of Manufacturing

Synthesis of Xylene Dimethyl Ether 350 kg of water was added to the reactor and 150 kg of NaOH was added with stirring. After dissolving, the temperature was lowered to 10 ℃, 110 kg of resorcinol was added, and dissolved by stirring. Then, 126 kg of dimethyl sulfate was slowly added and reacted at 26-30 ℃ for 2 h. Dilute with water, separate the oil layer, and wash the oil layer to neutral with water. Removal of low Buddha point, distillation to collect 215 ~ 220 ℃ distillate, that is m-xylylene ether. Synthesis of 2-hydroxy-4-methoxybenzophenone First, 300 kg of chlorobenzene was added to the condensation kettle, with stirring, the catalyst AlCl3 350 kg and isophthalic ether 120 kg were added. Heat to about 80 ℃, slowly add 320 kg of benzoyl chloride. Reflux for 4 to 6 hours, cool, hydrolyze, distill off the solvent, cool, crystallize, and dry to obtain 2-hydroxy-4-methoxybenzophenone. Synthesis of 2-hydroxy-4-methoxy-5-sulfonated diphenylacetone First add 93% sulfuric acid to the sulfonation kettle, slowly add 2-hydroxy-4-methoxydibenzoyl under stirring Ketones are reacted at about 110 ℃ for 4 to 6 hours, cooled, crystallized, dried, and recrystallized to be the finished product.

Uses

As an anti-ultraviolet finishing agent, it has good anti-aging and softening effects on cotton fabrics and polyester fibers. It is widely used in sunscreen creams, creams, honey, lotions, oils and other cosmetics; it is a broad-spectrum ultraviolet absorber with high absorption efficiency, non-toxic, no teratogenic side effects, and good light and heat stability. It can absorb UV-A and UV-B at the same time. It is a class I sunscreen approved by the U.S. FDA. It is used more frequently in the U.S. and Europe. It is widely used in sunscreen cosmetics such as sunscreen creams, creams, honey, lotions, oils, etc. Ultraviolet finishing agent has good anti-aging and softening effects on cotton fabrics and polyester fibers. Mainly used as sunscreen and sunscreen in water-soluble cosmetics, as well as UV absorber in other water-soluble inks and coatings; mainly used as sunscreen and sunscreen in water-soluble cosmetics, and also in other water-soluble inks Used as UV absorber in paint, etc.