ETHANONE, 2-BROMO-1-CYCLOPROPYL- 69267-75-0

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

ETHANONE, 2-BROMO-1-CYCLOPROPYL- Basic information Product Name: ETHANONE, 2-BROMO-1-CYCLOPROPYL- Synonyms: ETHANONE, 2-BROMO-1-CYCLOPROPYL-;Ethanone, 2-bromo-1-cyclopropyl- (9CI);Cyclopropylbromomethylketone;2-BROMO-1-CYCLOPROPYL ETHANONE;2-Bromo-1-cyclopropylethan-1-one;Bromoacetylcyclopropane;2-Bromomethyl Cyclopropylketone;Bromomethyl cyclopropylketone CAS: 69267-75-0 MF: C5H7BrO MW: 163.01 EINECS: Product Categories: API intermediates;Carbonyl Compounds;Halides;ACETYLHALIDE Mol File: 69267-75-0.mol ETHANONE, 2-BROMO-1-CYCLOPROPYL- Chemical Properties Boiling point  60-65 °C(Press: 10 Torr) density  1.669 refractive index  1.543 storage temp.  Inert atmosphere,Store in freezer, under -20°C solubility  Chloroform, Ethyl Acetate (Slightly) form  Liquid color  Clear Colourless InChIKey WCCCDMWRBVVYCQ-UHFFFAOYSA-N Safety Information Risk Statements  36 Safety Statements  26 RIDADR  UN 2811 6.1 / PGIII HazardClass  IRRITANT HS Code  2914790090 ETHANONE, 2-BROMO-1-CYCLOPROPYL- Usage And Synthesis Uses 2-Bromo-1-cyclopropylethanone is an intermediate used to prepare pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. It is also used to synthesize indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line. Synthesis 765-43-5 69267-75-0 The general procedure for the synthesis of 1-cyclopropyl-2-bromoacetophenone from cyclopropylmethyl ketone was as follows: a methanol (MeOH, 100 mL) solution of cyclopropylmethyl ketone (20.7 mL, 220 mmol) was treated with bromine (11.3 mL, 220 mmol) at -5 °C and the reaction lasted for 2 hours. Subsequently, 50 mL of water was added to the reaction mixture and the reaction system was slowly warmed to room temperature and left to stand overnight. After completion of the reaction, the mixture was diluted with 150 mL of water and extracted with ether. The organic phase was separated, washed with sodium bicarbonate (NaHCO3) solution, dried over anhydrous sodium sulfate (Na2SO4), and concentrated to remove the solvent to give the light yellow oily product 1-cyclopropyl-2-bromoacetophenone (35 g, 99% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 0.91-1.02 (m, 2H), 1.03-1.16 (m, 2H), 2.08-2.20 (m, 1H), 4.02 (s, 2H). References [1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 22 [2] Patent: WO2013/184734, 2013, A1. Location in patent: Paragraph 00299; 00300 [3] Synlett, 2010, # 6, p. 873 - 876 [4] Patent: WO2010/96395, 2010, A1. Location in patent: Page/Page column 34 [5] Patent: WO2015/76800, 2015, A1. Location in patent: Page/Page column 318 ETHANONE, 2-BROMO-1-CYCLOPROPYL- Preparation Products And Raw materials Raw materials Cyclopropyl methyl ketone-->Methanol Preparation Products 4-Cyclopropyl-1(3)H-iMidazole-->2-Amino-4-cyclopropylthiazole-->Thiazole, 4-cyclopropyl-2-methyl--->2-Bromo-1-cyclopropylethanol



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.