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Choline glycerophosphate CAS:28319-77-9

Name: Choline glycerophosphate CAS:28319-77-9
Brand: Orient
SKU: pr2511281644
Price: 5 USD
Availability: InStock

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CAS No.:

28319-77-9

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-28

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Choline glycerophosphate Basic information

Product Name:	Choline glycerophosphate
Synonyms:	2-[[(2R)-2,3-dihydroxypropoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium;L-A-GLYCEROPHOSPHORYLCHOLINE FROM*EGG YOLK FREE FORM;L-A-GLYCEROPHOSPHORYLCHOLINE FROM SOYBEAN, FREE FORM;L-α-GLYCERYLPHOSPHORYLCHOLINE(GPC);,hydroxide,innersalt,(r)-;L-a-Glycerophosphorylcholine (anhydrous) (GPC);GLYCERYLPHOSPHOCHOLINE;L-A-GLYCEROPHOSPHOCHOLINE
CAS:	28319-77-9
MF:	C8H20NO6P
MW:	257.22
EINECS:	248-962-2
Product Categories:	GPC;Smart drug;Activity;Enzyme Substrates;Activity Other;pharmaceutical ingredients;28319-77-9
Mol File:	28319-77-9.mol

Choline glycerophosphate Chemical Properties

Melting point	142.5-143°
alpha	D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
Boiling point	480℃[at 101 325 Pa]
vapor pressure	0Pa at 25℃
Fp	11 °C
storage temp.	-20°C
solubility	DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly)
form	solid
color	White to Off-White
biological source	soybean
Water Solubility	1000g/L at 25℃
Stability:	Very Hygroscopic
InChI	InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
InChIKey	SUHOQUVVVLNYQR-SBYBRXNCNA-N
SMILES	P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO \|&1:12,r\|
LogP	-5.15 at 25℃
CAS DataBase Reference	28319-77-9(CAS DataBase Reference)

Safety Information

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	16-36/37-45-24/25
RIDADR	UN 1230 3/PG 2
WGK Germany	2
RTECS	KH2775000
HS Code	29239000

MSDS Information

Choline glycerophosphate Usage And Synthesis

Description	Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
Chemical Properties	Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
Originator	Sandoz; Italfarmaco (Italy)
Uses	sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
Uses	L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.
Definition	ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
Brand name	Delecit
General Description	L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Flammability and Explosibility	Not classified
Biochem/physiol Actions	Increases inositol phosphate formation.
Synthesis	10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).

2,7-Dihydroxynaphthalene Usage And Synthesis

Chemical Properties

Light yellow to grey needle crystal

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

sn-glycero-3-Phosphocholine

Other Name:

Ethanaminium,2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-,inner salt;Choline,hydroxide,2,3-dihydroxypropyl hydrogen phosphate,inner salt,D-;Ethanaminium,2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-,hydroxide,inner salt,(R)-;O-(sn-glycero-3-Phosphoryl)-choline;Glycerophosphorylcholine;sn-glycero-3-Phosphorylcholine;sn-glycero-3-Phosphorylcholine;L-α-Glycerophosphorylcholine;L-α-Glycerylphosphorylcholine;Glycerophosphocholine;L-α-Glycerophosphocholine;Choline alfoscerate;Ethanaminium,2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-,inner salt,(R)-;Gliatilin;Delecit;Brezal;L-α-GPC;Glycerol 3-phosphocholine;Glycerol 3-phosphorylcholine;Glycerophosphoric acid choline ester;α-Glycerophosphorylcholine;Glycerylphosphocholine;α-Glycerylphosphorylcholine;Glyceryl 3-phosphorylcholine;Glycerylphosphorylcholine;sn-glycero-3-Phosphocholine;Cholitiline;Cholicerin;Cereton;Choline alphoscerate;Glycerol phosphorylcholine;Nichiyu GPC 85R;103709-68-8;117829-79-5;1617495-71-2;1873315-25-3

CAS No.:

28319-77-9

UN No.:

1230

Molecular Formula:

C8H20NO6P

InChIKeys:

InChIKey=SUHOQUVVVLNYQR-MRVPVSSYSA-N

Molecular Weight:

257.22100

Exact Mass:

257.10300

EC Number:

248-962-2

UNII:

60M22SGW66

ATC Code:

N - Nervous system

HScode:

2923900090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

108.86000

XLogP3:

-2.3

Appearance:

Solid

Melting Point:

142.5 °C

Flash Point:

11 °C

Refractive Index:

1.329 (20ºC)

Storage Conditions:

-20ºC

Collision Cross Section:

155.5 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|157.17 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|161.8 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]

See More sn-glycero-3-Phosphocholine Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More sn-glycero-3-Phosphocholine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Choline alfoscerate BP/USP	1.00 20' Fcl	Jun 28, 2025
India	Alpha GPC	1 KG	Oct 15, 2023
Portugal	alpha GPC	50 G	Oct 14, 2023
India	Alpha GPC	50 KG	Nov 20, 2024

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