High Quality Alpha GPC/Choline Alfoscerate/L-Alpha glycerylphosphorylcholine Powder CAS 28319-77-9

Alpha-GPC More Info

Alpha-GPC (alpha-glycerophosphocholine), also known as choline alfoscerate or L-alpha glycerylphosphorylcholine, is a naturally occurring choline compound found in the brain. It is also available as a dietary supplement. In Europe, alpha-GPC is a prescription medication used to treat Alzheimer's disease.

Mechanism of Action

Alpha-GPC is a precursor to acetylcholine, a neurotransmitter crucial for learning and memory. It readily crosses the blood-brain barrier to deliver choline to the brain. By increasing acetylcholine release, alpha-GPC can potentially improve cognitive functions. Alpha-GPC also contributes to the synthesis of phosphatidylcholine, a major component of cell membranes, supporting overall brain health. Additionally, alpha-GPC has been found to potentiate potassium-invoked calcium release in the hippocampus.

Applications

Alpha-GPC is used for:
As a dietary supplement for cognitive enhancement and to improve memory, thinking skills, and learning.
Treatment of Alzheimer's disease (prescription medication in Europe).
Potentially improving cognitive symptoms (e.g., memory and attention impairment) in older adults with mild to moderate dementia.
Improving the effectiveness of acetylcholinesterase inhibitors (drugs that increase acetylcholine’s availability by slowing down its breakdown), which are used for treating Alzheimer’s disease.
Improving behavioral, functional, and cognitive symptoms when added to standard Alzheimer’s treatment.
Stroke and "mini-stroke" (transient ischemic attack, TIA).
Enhancing physical performance.
Alpha-GPC may also help those with glioblastoma, a type of brain cancer that is very difficult to treat.

Routes of Administration

Alpha-GPC is administered orally

Safety and Side Effects

Alpha-GPC is likely safe when used appropriately and in low doses. The FDA considers alpha-GPC as generally recognized as safe (GRAS) for intakes of no more than 196.2 mg per person per day.
Side effects may include:
Heartburn
Headaches
Confusion
Skin rash or redness
Dizziness
Fatigue
Nervousness
Nausea
Diarrhea
Gastrointestinal distress
Low blood pressure
A study found that Alpha-GPC users were at a higher risk for stroke than non-users and that higher doses of alpha-GPC increased the risk for stroke. Little research has been done on Alpha GPC's effects on pregnant women, so those who are pregnant or nursing are advised to refrain from use.

Pharmacokinetics

After intravenous administration in rats, Alpha-GPC distributes widely, concentrating particularly in the liver, kidney, lung, and spleen. Oral ingestion of Alpha-GPC increases plasma choline concentrations. One study reported an increase in plasma choline with 1,000mg Alpha-GPC in otherwise healthy young men from 8.1+/-1.4μmol/L up to 12.1+/-1.9μmol/L (49% at 60 minutes) and 11.4+/-1.7μmol/L (41% at 120 minutes). Alpha-GPC is hydrolyzed by phosphodiesterases in the gut mucosa.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.