 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > β-Propiolactone for Sale > 2-Oxetanone CAS:57-57-8

2-Oxetanone CAS:57-57-8 buy - large image1

2-Oxetanone CAS:57-57-8

Name: 2-Oxetanone CAS:57-57-8
Brand: Orient
SKU: pr2511281647
Price: 5 USD
Availability: InStock

TDS 3 Inquiries

Unit Price: Get Latest Price 

CAS No.:

57-57-8

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2025-12-28

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

2-Oxetanone Basic information

Product Name:	2-Oxetanone
Synonyms:	Beta-propiolactone, 98%, pure;Propiolactone research grade;β-Propiolactone ,98%;BETA-PROPIOLACTONERESEARCH GRADE;β-Propiolactone,3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone;b-Propiolactone, Reagent;beta-Hydroxypropionic Acid Lactone 2-Oxetanone beta-Propionolactone;BETA-HYDROXYPROPIONIC ACID LACTONE
CAS:	57-57-8
MF:	C3H4O2
MW:	72.06
EINECS:	200-340-1
Product Categories:	Building Blocks;Carbonyl Compounds;Chemical Synthesis;Lactones;Organic Building Blocks;Heterocycles;Intermediates & Fine Chemicals;Miscellaneous Reagents;Pharmaceuticals;BPL
Mol File:	57-57-8.mol

2-Oxetanone Chemical Properties

Melting point	-33 °C (lit.)
Boiling point	162 °C (lit.)
density	1.146 g/mL at 25 °C (lit.)
vapor pressure	3 at 25 °C (NIOSH, 1997)
refractive index	n20/D 1.412(lit.)
Fp	158 °F
storage temp.	-20°C
solubility	Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
form	Liquid
color	Colorless liquid with a sweet but irritating odor
Odor	pungent odor
Water Solubility	37 g/100 mL
Sensitive	Moisture Sensitive
Merck	14,7820
Henry's Law Constant	7.6 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Stability:	Moisture Sensitive, Very Hygroscopic
InChIKey	VEZXCJBBBCKRPI-UHFFFAOYSA-N
CAS DataBase Reference	57-57-8(CAS DataBase Reference)
IARC	2B (Vol. 4, Sup 7, 71) 1999
NIST Chemistry Reference	«beta»-Propiolactone(57-57-8)
EPA Substance Registry System	beta-Propiolactone (57-57-8)

Safety Information

Hazard Codes	T+
Risk Statements	45-26-36/38
Safety Statements	53-45-99
RIDADR	UN 3382 6.1/PG 1
WGK Germany	3
RTECS	RQ7350000
TSCA	Yes
HazardClass	6.1
PackingGroup	I
HS Code	29322090
Hazardous Substances Data	57-57-8(Hazardous Substances Data)
Toxicity	LC50 (inhalation) for rats 25 ppm/6-h (quoted, RTECS, 1985).

2-Oxetanone Usage And Synthesis

Description	Beta-propiolactone is a colorless liquid with a strong, slightly sweet odor. It may occur naturally, but no clear documentation of its occurrence in nature was found, and it must be synthesized for commercial purposes. Beta-propiolactone is unstable at room temperature but stable when stored at 5 ℃ in glass containers. Its tendency to be unstable and react with other molecules in the vicinity is responsible for both its toxicity and its usefulness. Significant commercial production of beta-propiolactone took place during the late 1950s through the mid-1970s, when it was widely used in chemical synthesis in reactions with other molecules to produce new chemicals. All lactones are characterized by a ring structure consisting of two or more carbon atoms – as can be seen from its structure, beta-propiolactone has three in its ring – and a single oxygen, coupled with an adjacent ketone. The fewer the carbons in the ring, the more ‘strained’ is the ring structure and the more unstable and reactive its characteristics. When the ring bonds break, the betapropiolactone molecules attach to other nearby molecules.
Chemical Properties	β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable. It reacts with alcohols, acid chlorides, ammonia, and water to yield β-substituted propionic acid derivatives. The most important characteristic of the substance is its ability to polymerize. This highly exothermic process occurs simply by warming, although it is also catalyzed by both acid and base.
Physical properties	β-Propiolactone is a colorless, highly reactive liquid,thatis solublein water, alcohol, acetone, and chloroform (solubilityinwaterat 25℃, 37 vol %).
Uses	Reacts with bacteriphage DNA causing inactivation, repair and recombination
Uses	As late as 1974, b-propiolactone was used in the United States in the preparation of acrylic acid and acrylate esters. Today, its principal significance is as a reactive intermediate in organic syntheses; a small amount is treated with ammonia to provide balanine. b-Propiolactone was also used as a disinfectant. It appeared to be an attractive replacement for formaldehyde due to its 25-fold greater disinfecting power, but it has since been abandoned because of its carcinogenic properties.
Uses	Versatile intermediate in organic synthesis.

Shop Orthophosphorus acid 10294-56-1-Detailed Image 1

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 2

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 3

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 4

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 5

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 6

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 7

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 8

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 9

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 10

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 11

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 12

—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

β-Propiolactone

Other Name:

2-Oxetanone;Hydracrylic acid,β-lactone;Betaprone;BPL;Propanolide;Propiolactone;β-Propiolactone;β-Propionolactone;Propanoic acid,3-hydroxy-,β-lactone;1,3-Propiolactone;3-Hydroxypropionic acid lactone;3-Propanolide;3-Propiolactone;NSC 21626

CAS No.:

57-57-8

Molecular Formula:

C3H4O2

InChIKeys:

InChIKey=VEZXCJBBBCKRPI-UHFFFAOYSA-N

Molecular Weight:

72.06

Exact Mass:

72.06

EC Number:

200-340-1

UNII:

6RC3ZT4HB0

ICSC Number:

0555

NSC Number:

758422|21626

UN Number:

2810

DSSTox ID:

DTXSID8021197

NCI Thesaurus Code:

C44339

Color/Form:

A COLORLESS LIQUID|Colorless liquid.

HScode:

2932209090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

26.3

XLogP3:

0.46 (estimated)

Appearance:

Liquid

Density:

1.1460 g/cm³ @ Temp: 20 °C

Melting Point:

-33.4 °C

Boiling Point:

61 °C @ Press: 20 Torr

Flash Point:

158 °F

Refractive Index:

1.445

Water Solubility:

H2O: 37 g/100 mL

Storage Conditions:

2-8°C

Vapor Pressure:

Vapour pressure, Pa at 25°C: 453

Vapor Density:

2.5

Toxicity:

Inhalation-rat LC50: 25 ppm/6 hours; peritoneal-mouse LD50: 405 mg/kg

Flammability characteristics:

Flammable; spicy and irritating smoke is released in the fire; rapid hydrolysis in water

Explosive limit:

vol% in air: 2.9

Odor:

PUNGENT

Experimental Properties:

VERY HIGH CHEMICAL REACTIVITY DUE TO PRESENCE OF STRAINED FOUR-MEMBERED LACTONE RING|DECOMP IN WATER & ALCOHOL

Air and Water Reactions:

Slow reaction with water to form beta- hydroxypropionic acid.

Reactive Group:

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Reactivity Profile:

BETA-PROPIOLACTONE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical may be incompatible with alkalis.

Flammable Limits:

LOWER FLAMMABLE LIMIT: 2.9%|Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

See More β-Propiolactone Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 2, Inhalation

Carcinogenicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H330 Fatal if inhaled H350 May cause cancer
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P203 Obtain, read and follow all safety instructions before use.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P320 Specific treatment is urgent (see ... on this label). P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Above 74Â°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. Cooled. Well closed. Ventilation along the floor.MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED .

See More β-Propiolactone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Egypt	Beta Propiolactone	1 KG	Oct 19, 2025
United States	beta-Propiolactone	1 G	Sep 26, 2024
South Korea	Propiolactone 99.9% powder door to door 100% safe LIKES	4 KG	Sep 1, 2023

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
57-57-8	/		Guangzhou Yaoguang Technology Co., Ltd.	Inquiry
57-57-8 2-Oxetanone liquid	Industrial Grade/98		Shandong zhishang chemical Co.,Ltd	Inquiry
2-Oxetanone 98% liquid KieRay Chem KieRay Chem	industrial Grade/98		Hangzhou KieRay Chem Co.,LTD	Inquiry
In stock 2-Oxetanone cas no.57-57-8 KINDCHEM	Industrial Grade/98		Kindchem Co., Ltd	Inquiry
BETA-PROPIOLACTONE98%	Industrial Grade/99	$0.1/KG EXW	Hangzhou Raisun Import & Export Co Ltd	Inquiry

Hot Related Products



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.

2-Oxetanone CAS:57-57-8

Product Description

Seller Information