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BIS-Tris CAS:6976-37-0

Name: BIS-Tris CAS:6976-37-0
Brand: Orient
SKU: pr2511301017
Price: 2 USD
Availability: InStock

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CAS No.:

6976-37-0

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-30

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

BIS-Tris Basic information

Product Name:	BIS-Tris
Synonyms:	2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)-METHANE;2-BIS[2-HYDROXYETHYL]AMINO-2-[HYDROXYMETHYL]1,3-PROPANEDIOL;2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-3-propanediol;Bis Tris Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane;Bis Tris, Molecular Biology Grade Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane, Molecular Biology Grade;Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane~Bis-TRIS;Bis-Tris (2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol);BIS-TRIS BIOULTRA, >= 99.0% (NT)
CAS:	6976-37-0
MF:	C8H19NO5
MW:	209.24
EINECS:	230-237-7
Product Categories:	Buffer;API intermediates
Mol File:	6976-37-0.mol

BIS-Tris Chemical Properties

Melting point	104 °C(lit.)
Boiling point	466.2±40.0 °C(Predicted)
density	1.346±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Solution
color	Yellow to orange
Odor	Odorless
PH	9.0-10.1 (20-25℃, 1M in water)
PH Range	5.8 - 7.2
pka	6.5(at 25℃)
biological source	synthetic
Water Solubility	soluble
λmax	λ: 280 nm Amax: 0.15
Sensitive	Air Sensitive
BRN	2205275
InChIKey	OWMVSZAMULFTJU-UHFFFAOYSA-N
LogP	-2.26 at 20℃
CAS DataBase Reference	6976-37-0(CAS DataBase Reference)
EPA Substance Registry System	1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0)
Absorption	cut-off at 270nm in H2O at 1M

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-21/22-20/21/22
Safety Statements	26-36-36/37/39-22
WGK Germany	3
F	10-23
TSCA	Yes
HS Code	29221980

BIS-Tris Usage And Synthesis

Chemical Properties	White/clear crystalline powder
Uses	It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.
Uses	Bis Tris is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36 which makes it a good candidate for biological-based formulations. Bis Tris is used in a wide variety of biological applications including protein separation buffers, cell culture media, electrophoresis separations and diagnostic reagent formulations.
Uses	Bis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.
Definition	ChEBI: Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 ℃. It has a role as a buffer. It is functionally related to a member of tris.
Flammability and Explosibility	Not classified
Purification Methods	Crystallise BIS-TRIS from hot 1-butanol and dry it in a vacuum at 25o. N,N-Bis-(2-hydroxyethyl)glycine (BICINE) See in “Amino Acids and Peptides”, Chapter 6.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Bistris

Other Name:

1,3-Propanediol,2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-;2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol;2,2-Bis(hydroxymethyl)-2,2′,2′′-nitrilotriethanol;Bistris;NSC 119932;NSC 24868;NuPage Bis-Tris

CAS No.:

6976-37-0

Molecular Formula:

C8H19NO5

InChIKeys:

InChIKey=OWMVSZAMULFTJU-UHFFFAOYSA-N

Molecular Weight:

209.24000

Exact Mass:

209.24

EC Number:

230-237-7

UNII:

Q1XC3631CP

NSC Number:

119932|24868

DSSTox ID:

DTXSID6064537

HScode:

29221980

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

104.39000

XLogP3:

-3.3

Appearance:

Liquid

Density:

1.346 g/cm3

Melting Point:

103-104ºC

Boiling Point:

466.2ºC at 760 mmHg

Flash Point:

288ºC

Refractive Index:

1.563

Water Solubility:

H2O: soluble

Storage Conditions:

Store at RT.

See More Bistris Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Bistris Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane	5000 KG	Apr 11, 2025

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