High Quality Chemicals 99% Purity Peptide Oxytocin/Oxystin Powder CAS 50-56-6 Oxytocin Acetate

1.  Description

        Chemical Properties: Oxytocin Acetate is a cyclic nonapeptide compound with the amino acid sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂ (cysteine residues at positions 1-6 form disulfide bonds to create a closed ring). The acetate salt form significantly enhances water solubility and stability. Its primary target is the oxytocin receptor (OXTR) distributed in the uterus, mammary glands, and central nervous system, exerting physiological effects by activating the G protein-coupled receptor pathway. Chemically stable, it resists hydrolysis in neutral to weakly acidic environments (pH 4.5-7.0). The disulfide bond structure requires protection from strong reducing agents. It exhibits excellent compatibility with clinically common solvents such as saline and glucose solutions.

    Physical Properties: Oxytocin Acetate appears as a white to off-white crystalline powder at room temperature. It is odorless, hygroscopic, and highly water-soluble (solubility ≥100 mg/mL). It is slightly soluble in ethanol and insoluble in non-polar solvents such as ether and chloroform. Molecular weight: 1066.2 Da (acetate form). Store at 2-8°C in a dry, sealed container protected from light; avoid repeated freeze-thaw cycles. Clinical-grade/research-grade products exhibit ≥98% purity (HPLC-detected), ≤1.0% impurities, 5.0%-12.0% acetate content, and are free of endotoxins and heavy metal residues.

     Source and Preparation: Oxytocin Acetate is naturally produced in the paraventricular and supraoptic nuclei of the human hypothalamus and released into the bloodstream via the posterior pituitary gland. Industrially synthesized via precise solid-phase peptide synthesis using high-purity L-amino acids as raw materials. The process involves condensation, cyclization (forming disulfide bonds), deprotection, amidation modification, and acetylation to form the salt. The final high-purity product is obtained through high-performance liquid chromatography (HPLC) purification. The synthesis process strictly controls disulfide bond formation efficiency to ensure peptide chain structural integrity and receptor binding activity. Product quality is validated through mass spectrometry (MS) and amino acid sequence analysis.

2.  Application

     Clinical Medicine Field (Core Applications): Oxytocin Acetate, as a core clinical obstetrics and gynecology medication, is approved for use in labor induction (promoting cervical ripening and initiating contractions in full-term pregnancies), labor augmentation (enhancing contractions during labor when uterine contractions are inadequate), postpartum hemorrhage control (promoting uterine contraction to reduce postpartum bleeding), and lactation stimulation (stimulating smooth muscle contraction in mammary glands to promote milk ejection). Additionally, it is being studied in psychiatry as an adjunctive treatment for autism and social anxiety disorder, and in cardiology for potential applications in heart failure and hypertension. Several indications are currently in Phase II clinical trials.

     Biomedical Research Field: As a core tool reagent for neuropeptide mechanism studies, Oxytocin Acetate is used to investigate mechanisms underlying social behavior regulation (trust, empathy, parent-child bonding), reproductive physiology, and emotional memory formation. Through in vitro models such as neuronal cells and uterine smooth muscle cells, as well as animal models like mice and rats, it analyzes its regulatory effects on the OXTR pathway, neurotransmitter release, and uterine contractility, providing experimental evidence for drug development in reproductive medicine and neuroscience.

    Potential Functional Health and Aesthetic Medicine Applications: Leveraging its social behavior modulation and emotional association properties, Oxytocin Acetate holds potential for use in premium mood-regulating dietary supplements (subject to strict regulatory compliance). In aesthetic medicine, it is being explored for improving facial microcirculation (via local vasodilation) and alleviating emotional flushing triggered by skin sensitivity. These applications are currently in the basic research phase and have not yet been commercialized.

3. Main Efficacy

       Core Function in Reproductive System Regulation: Oxytocin Acetate's primary mechanism involves activating OXTR receptors on uterine smooth muscle cells. This promotes calcium ion influx, triggering rhythmic contractions of the uterine smooth muscle. Contraction intensity correlates positively with dosage—low doses induce physiological contractions for labor induction/augmentation, while high doses rapidly contract the uterine muscle layer to compress blood vessels for postpartum hemostasis. Simultaneously activates OXTR on myoepithelial cells surrounding mammary alveoli, contracting ducts to promote milk ejection and achieve lactation-stimulating effects. Clinically, its uterine contraction action exhibits high targeting with minimal impact on other smooth muscle tissues.

    Social Behavior and Emotional Regulation Effects: As the “hug hormone,” Oxytocin Acetate activates OXTR receptors in the central nervous system (hypothalamus, amygdala, prefrontal cortex) to regulate neurotransmitter release (dopamine, serotonin), enhancing trust, empathy, and social bonding. It improves social avoidance behaviors in autism patients and alleviates fear associated with social anxiety disorder. It also participates in emotional memory formation, reinforcing positive emotional associations while diminishing the impact of negative memories, offering a novel therapeutic target for emotional disorders.

    Multisystem Protection and Regulation: In the cardiovascular system, Oxytocin Acetate improves myocardial perfusion by vasodilation and reduced peripheral resistance, inhibits myocardial remodeling, and demonstrates cardiac function protection in heart failure mouse models. In the immune system, it modulates T-cell and macrophage activity to enhance anti-infective capacity. In the digestive system, it promotes gastrointestinal motility and alleviates postoperative gastrointestinal paralysis, with mechanisms linked to OXTR-mediated smooth muscle contraction and neuromodulation.

    Safety Advantages: As an endogenous peptide, Oxytocin Acetate exhibits exceptional biocompatibility. At standard clinical doses, adverse reactions are mild (occasional nausea, vomiting, transient hypotension). Overdose may induce uterine tetanic contractions (strict dosage control required). It exhibits no addictive potential or long-term toxicity. No significant withdrawal symptoms have been observed in psychiatric applications, demonstrating superior tolerability compared to synthetic small-molecule psychotropic drugs.