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Chloroquine diphosphate 50-63-5

Name: Chloroquine diphosphate 50-63-5
Brand: Orient
SKU: pr2512121450
Price: 4 USD
Availability: InStock

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CAS No.:

50-63-5

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

1KG, 25KG, 200KG, 1000KG, customized

Price valid (until):

2026-01-12

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Product Name:	Chloroquine diphosphate
Synonyms:	7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat;ARALEN PHOSPHATE;CHLOROQUINE DIPHOSPHATE;CHLOROQUINE DIPHOSPHATE SALT;CHLOROQUINE PHOSPHATE;7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID;CHLOROQUINE PHOSPHATE BP;CHLOROQUINE PHOSPHATE BP98
CAS:	50-63-5
MF:	C18H32ClN3O8P2
MW:	515.86
EINECS:	200-055-2
Product Categories:	Inhibitors;ARALEN;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Enzyme;API;50-63-5;Coronavirus
Mol File:	50-63-5.mol

Chloroquine diphosphate Chemical Properties

Melting point	200 °C (dec.) (lit.)
vapor pressure	<0.0000001 kPa ( 25 °C)
storage temp.	protect from light
solubility	H₂O: 50 mg/mL, clear
pka	pKa 8.10(H2O t = 20 c = 0.0025) (Uncertain)
form	solid
color	White
PH	pH(100g/l, 25℃) : 3.8～4.3
biological source	synthetic
Water Solubility	Soluble in water
Merck	14,2163
BRN	4223142
BCS Class	1
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChIKey	QKICWELGRMTQCR-UHFFFAOYSA-N
CAS DataBase Reference	50-63-5(CAS DataBase Reference)
EPA Substance Registry System	Chloroquine diphosphate (50-63-5)

Safety Information

Hazard Codes	Xn
Risk Statements	22-40-20/21/22
Safety Statements	22-24/25-36
RIDADR	1544
WGK Germany	3
RTECS	VB2450000
F	10
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933492250
Toxicity	LD50 oral in rat: 623mg/kg

MSDS Information

Chloroquine diphosphate Usage And Synthesis

Description	Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial, anti-inflammatory, anticancer, and antiviral activities. Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 μM. It is active against the chloroquine-sensitive GC03 strain of P. falciparum (IC₅₀ = 29.2 nM) but has decreased activity against mutant pfcrt P. falciparum (IC₅₀s = 100-150 nM). Chloroquine prevents infection by severe acute respiratory coronavirus 2 (SARS-CoV-2) in Vero cells (EC₅₀ = 1.13 μM) but does not inhibit SARS-CoV replication in the lungs in a mouse model of SARS-CoV infection. It inhibits the growth of human SSC25 and CAL 27 oral squamous cell carcinoma cells (IC₅₀s = 29.9 and 17.3 μM, respectively), as well as A498, SN12C, RXF 393, and 769-P renal cancer cells (IC₅₀s = 16, 62, 81, and 25 μM, respectively). It reduces tumor growth in a CAL 27 mouse xenograft model and a 4T1 mouse allograft model when administered at a dose of 50 mg/kg. Formulations containing chloroquine have been used in the prevention of malaria, as well as the treatment of rheumatoid arthritis and systemic lupus erythematosus (SLE), and have been associated with cardiotoxicity and myopathy.
Chemical Properties	White Solid
Originator	Nivaquine,Specia,France,1949
Uses	Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.
Uses	Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ
Uses	antimalarial, antiamebic, antirheumatic, intercalating agent
Uses	An antimalarial compound
Manufacturing Process	105 g of 4,7-dichloroquinoline (MP 93 to 94°C) are heated with 200 g of 1- diethylamino-4-aminopentane for 7 hours in an oil bath to 180°C while stirring, until a test portion dissolved in diluted nitric acid does not show a precipitation with sodium acetate solution. The mixture is dissolved in diluted acetic acid and made alkaline by adding sodium lye. The base is extracted with ether, dried with potassium carbonate, the ether removed by distillation and the residue fractionated. The 4-(5'- diethylaminopentyl-2'-amino)-7-chloroquinoline (BP 212 to 214C/0.2 mm) is obtained. On cooling the compound solidifies crystalline. It melts, recrystallized from benzene, at 88°C. The base combines with phosphoric acid to yield a diphosphate salt.

First aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx)

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

(±)-Chloroquine diphosphate

Other Name:

1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-,phosphate (1:2);Quinoline,7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-,phosphate (1:2);Quinoline,7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-,diphosphate;3377RP;SN 7618;Aralen diphosphate;Aralen phosphate;Avloclor;Bemaphate;7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate;Chloroquin diphosphate;Chloroquine diphosphate;Chloroquine phosphate;Nivaquine B;Resoquine;Sanoquin;Tanakan;Arechin;Resochin;Delagil;Quingamine;Chingamin;Chingamin phosphate;Gontochin phosphate;Khingamin;Chlorochin diphosphate;WR 1522;Chloroquine dihydrogen phosphate (1:2);Tanakan (antimalarial);(±)-Chloroquine diphosphate;dl-Chloroquine diphosphate;NSC 14050;Tresochin;Imagon;Malaquin;Alexoquine;Cidoquine;Maladrin;Quivaclor;6384-82-3;69698-56-2

CAS No.:

50-63-5

Molecular Formula:

C18H26ClN3.2H3O4P

InChIKeys:

InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N

Molecular Weight:

515.86

Exact Mass:

515.135315

EC Number:

200-055-2

DSSTox ID:

DTXSID7044681

HScode:

2933499090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

184

XLogP3:

3.02640

Appearance:

solid

Melting Point:

193-195 °C

Boiling Point:

189-193 °C @ Press: 0.2-0.3 Torr

Flash Point:

232.3ºC

Water Solubility:

soluble in water;H2O: 50 mg/mL, clear

Storage Conditions:

Desiccate at RT

Vapor Pressure:

5.0X10-9 mm Hg at 25 deg C (est)

Toxicity:

LD50 oral in rat: 623mg/kg

Collision Cross Section:

175.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More (±)-Chloroquine diphosphate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More (±)-Chloroquine diphosphate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Chloroquine Phosphate	1 KG	May 27, 2026
Pakistan	Chloroquine Phosphate	500 KG	May 9, 2025
Netherlands	Chloroquin Phosphate	2 MT	Jul 23, 2023
South Korea	Chloroquine Phosphate	10 G	Jul 20, 2023
India	Chloroquine diphosphate	1 G	Aug 7, 2025

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