Anti-Aging High Purity Kiss-10 Peptide CAS: 374675-21-5

1.  Description

     Chemical Properties: Kisspeptin-10 Fragment is a linear decapeptide compound with the amino acid sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe. It contains no modifying groups and targets G protein-coupled receptor 54 (GPR54, also known as KIS

S1R). It exhibits chemical stability and is resistant to hydrolysis in neutral to weakly acidic environments (pH 5.5–7.5), demonstrating superior resistance to peptidase degradation compared to long-chain kisspeptin. It is compatible with reproductive hormones such as gonadotropin-releasing hormone (GnRH) and follicle-stimulating hormone (FSH). Its molecular weight is 1213.4 Da.

     Physical Properties: Kisspeptin-10 Fragment appears as a white to off-white crystalline powder at room temperature, odorless and tasteless, excellent water solubility (solubility ≥30 mg/mL), rapidly dissolves in aqueous systems like pure water, saline, and phosphate-buffered saline (PBS), slightly soluble in ethanol and propylene glycol, insoluble in nonpolar solvents such as ether and petroleum ether. Store at -20°C in a dry, sealed, light-protected environment; avoid repeated freeze-thaw cycles. Research-grade/Application-grade products exhibit ≥98% purity (HPLC-assayed), ≤1.0% impurity, and are free of endotoxins and heavy metal residues.

     Source and Preparation: Kisspeptin-10 Fragment naturally occurs in human hypothalamus, pituitary gland, placenta, and other tissues, serving as a key neuropeptide regulating the reproductive axis. Industrially synthesized via solid-phase peptide synthesis using high-purity L-amino acids as raw materials. The process involves condensation, deprotection, peptide chain assembly, and final purification by high-performance liquid chromatography (HPLC) to yield a high-purity product. Reaction conditions are strictly controlled throughout synthesis to ensure structural integrity and biological activity. Product quality is validated by mass spectrometry (MS) and amino acid sequence analysis.

2.  Application

     Biomedical Research Field: Kisspeptin-10 Fragment serves as a core tool reagent for investigating reproductive endocrine mechanisms, applied in studies of pubertal development regulation, ovulation mechanisms, and dysfunctional reproductive axis function. Through in vitro models of hypothalamic neurons and pituitary cells, as well as mouse models of reproductive dysfunction (e.g., GPR54 knockout mice), it analyzes its regulatory effects on GnRH secretion and gonadotropin (LH/FSH) release, providing experimental evidence for basic reproductive medicine research and drug development.

     Clinical and Preclinical Development: Kisspeptin-10 Fragment serves as a therapeutic candidate for reproductive disorders, with core indications including: hypothalamic amenorrhea (e.g., exercise-induced amenorrhea, ovulatory dysfunction due to anorexia nervosa), male oligoasthenozoospermia, and optimization of ovulation induction protocols in assisted reproductive technology (ART). Simultaneously exploring reproductive endocrine regulation for polycystic ovary syndrome (PCOS). Currently, some indications are in Phase II clinical trials, with formulations primarily as subcutaneous injections and nasal sprays.

     Reproductive Health and Endocrine Maintenance: Kisspeptin-10 Fragment serves as a premium reproductive health ingredient for developing dietary supplements or functional products targeting populations with declining reproductive function (e.g., middle-aged/elderly men with reduced testosterone levels, women seeking prevention of premature ovarian insufficiency) and preconception groups (improving ovulation quality, optimizing reproductive endocrine environments). Its small-molecule structure enables intestinal absorption into the bloodstream, precisely activating reproductive axis function. It complies with EU and US dietary supplement regulations (requiring registration under the “research ingredient” or “reproductive health maintenance ingredient” category).

3. Main Efficacy

     Biomedical Research Field: Kisspeptin-10 Fragment serves as a core tool reagent for investigating reproductive endocrine mechanisms, applied in studies of pubertal development regulation, ovulation mechanisms, and dysfunctional reproductive axis function. Through in vitro models of hypothalamic neurons and pituitary cells, as well as mouse models of reproductive dysfunction (e.g., GPR54 knockout mice), it analyzes its regulatory effects on GnRH secretion and gonadotropin (LH/FSH) release, providing experimental evidence for basic reproductive medicine research and drug development.

     Clinical and Preclinical Development: Kisspeptin-10 Fragment serves as a therapeutic candidate for reproductive disorders, with core indications including: hypothalamic amenorrhea (e.g., exercise-induced amenorrhea, ovulatory dysfunction due to anorexia nervosa), male oligoasthenozoospermia, and optimization of ovulation induction protocols in assisted reproductive technology (ART). Simultaneously exploring reproductive endocrine regulation for polycystic ovary syndrome (PCOS). Currently, some indications are in Phase II clinical trials, with formulations primarily as subcutaneous injections and nasal sprays.

     Reproductive Health and Endocrine Maintenance: Kisspeptin-10 Fragment serves as a premium reproductive health ingredient for developing dietary supplements or functional products targeting populations with declining reproductive function (e.g., middle-aged/elderly men with reduced testosterone levels, women seeking prevention of premature ovarian insufficiency) and preconception groups (improving ovulation quality, optimizing reproductive endocrine environments). Its small-molecule structure enables intestinal absorption into the bloodstream, precisely activating reproductive axis function. It complies with EU and US dietary supplement regulations (requiring registration under the “research ingredient” or “reproductive health maintenance ingredient” category).