Name | Afloqualone |
CAS number | 56287-74-2 |
Description | Afloqualone is a quinazolinone derivative classified as a central nervous system depressant, with the CAS Registry Number 56287-74-2. Its molecular structure is based on a quinazolinone core, a heterocyclic framework distinct from that of benzodiazepines or barbiturates. |
Structural formula |  |
Molecular Formula | C16H14FN3O |
Molecular Weight | 283.3 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Afloqualone More Info
Afloqualone is a quinazolinone derivative classified as a central nervous system depressant, with the CAS Registry Number 56287-74-2. Its molecular structure is based on a quinazolinone core, a heterocyclic framework distinct from that of benzodiazepines or barbiturates. This specific chemical architecture was designed to target similar therapeutic endpoints—muscle relaxation and sedation—through interaction with the inhibitory neurotransmitter systems in the brain and spinal cord. It is typically described as a white crystalline solid in its pure form.
The primary pharmacological mechanism of afloqualone involves the potentiation of inhibitory neurotransmission mediated by gamma-aminobutyric acid. While its exact molecular target is not as clearly defined as for benzodiazepines, it is understood to act as a positive allosteric modulator at GABA-A receptors. By enhancing the effect of GABA, the brain's main inhibitory neurotransmitter, it increases chloride ion influx into neurons, leading to neuronal hyperpolarization. This results in the depression of neuronal excitability within the central nervous system, producing its characteristic sedative-hypnotic and centrally mediated muscle relaxant effects.
Historically, afloqualone was developed and clinically used as a prescription medication for its sedative and muscle relaxant properties. Its primary therapeutic application was in the management of conditions associated with muscle spasticity, such as in certain neurological disorders or musculoskeletal injuries. It was also utilized as a pre-anesthetic sedative and for the short-term treatment of insomnia due to its ability to induce sleep. Its clinical use was always intended for controlled, short-term management under medical supervision due to its inherent risks.
From a pharmaceutical perspective, afloqualone was formulated for oral administration, commonly in tablet form. Its pharmacokinetics involved good oral absorption and metabolism primarily in the liver, leading to the formation of active and inactive metabolites that were then excreted. The drug's profile, including its onset and duration of action, positioned it within a class of agents requiring careful dosing to balance efficacy with the risks of excessive sedation and the potential for dependence.
The safety profile of afloqualone is characterized by significant risks that ultimately led to severe restrictions or removal from many medical markets. Common side effects included drowsiness, dizziness, ataxia, and lightheadedness. Its most critical drawbacks were a high potential for abuse, the rapid development of tolerance and psychological dependence, and the risk of severe toxicity or death in overdose, particularly when combined with other CNS depressants like alcohol. Due to these substantial public health risks, it is now strictly controlled as a Schedule I substance under international drug control conventions and has no accepted medical use in most countries, serving instead as a compound of forensic and regulatory interest.
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