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Afloqualone

Afloqualone structure

CAS No:
56287-74-2
Formula:
C16H14FN3O
Chemical Name:
Afloqualone
Synonyms:
4(3H)-Quinazolinone,6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-;6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone;H 495;Afloqualone;HQ 495;Arofuto;Aroft;6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one;154088-26-3
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Afloqualone is a agonist of GABA receptor .Target: GABA Receptorin vitro: Afloqualone is a quinazolinone family GABAergic drug.Afloqualone is an analogue of methaqualone. It has sedative and muscle-relaxant effects, resulting from its agonist activity at the β subtype of the GABAa receptor.in vivo: Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively.

Afloqualone is an organic molecular entity.

Afloqualone Basic Attributes

Molecular Weight：

283.3

Exact Mass：

283.30

UNII：

CO4U2C8ORZ

DSSTox ID：

DTXSID5022562

Characteristics

PSA：

58.7

XLogP3：

1.28

Density：

1.3±0.1 g/cm3

Melting Point：

195-196 °C

Boiling Point：

492.5±55.0 °C at 760 mmHg

Flash Point：

251.7±31.5 °C

Refractive Index：

1.642

Toxicity：

Oral-rat LD50：249 mg/kg; Oral-Mouse LD50: 397 mg/kg

Flammability characteristics：

Flammable; burning releases toxic nitrogen oxide and fluoride fumes

Safety Information

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)|Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)

Metabolism/Metabolites：

Afloqualone has known human metabolites that include Afloqualone N-glucuronide.

MeSH Entry Terms：

afloqualone

Computed Properties

Molecular Weight:283.30
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:283.11209024
Monoisotopic Mass:283.11209024
Topological Polar Surface Area:58.7
Heavy Atom Count:21
Complexity:439
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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