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Isotretinoin 4759-48-2 C20H28O2

Name: Isotretinoin 4759-48-2 C20H28O2
Brand: Orient
SKU: pr2512171283
Price: 4 USD
Availability: InStock

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CAS No.:

4759-48-2

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Isotretinoin
Synonyms:	Tretinoin Impurity 1（Tretinoin EP Impurity A）;Anti Acne Powerful Isotretinoin Powder Isotretinoin Pharmaceutical Raw Materials;Isotretinoin Capsules;Isotretinoin-D5/13-cis-Retinoic acid-D5;Roaccutan;(2Z,4E,6E,8E)-3,7-diMethyl-9-(2,6,6-triMethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;ISOTRETINON;A different diMension acid
CAS:	4759-48-2
MF:	C20H28O2
MW:	300.44
EINECS:	225-296-0
Product Categories:	Other APIs;intermediates;Organic acids;APIs;API;BUSPAR;Antibiotics;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;4759-48-2
Mol File:	4759-48-2.mol

Isotretinoin Chemical Properties

Melting point	172-175 °C (lit.)
Boiling point	381.66°C (rough estimate)
density	1.0597 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	-20°C
solubility	Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
pka	4.76±0.33(Predicted)
form	Fine Crystalline Powder
color	Yellow-orange to orange
biological source	synthetic
Water Solubility	insoluble
λmax	354nm(EtOH)(lit.)
Merck	14,5228
Stability:	Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	ANTI-SEBUM
InChIKey	SHGAZHPCJJPHSC-YCNIQYBTSA-N
CAS DataBase Reference	4759-48-2(CAS DataBase Reference)
EPA Substance Registry System	Isotretinoin (4759-48-2)

Safety Information

Hazard Codes	T
Risk Statements	61-36/37/38-20/21/22
Safety Statements	53-26-36/37/39-45-37/39
WGK Germany	3
RTECS	VH6440000
TSCA	Yes
HS Code	29362100
Hazardous Substances Data	4759-48-2(Hazardous Substances Data)
Toxicity	LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)

MSDS Information

Isotretinoin Usage And Synthesis

Pharmacological effects	Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne. The mechanism is as follows: ① it can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment. ② it has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands. ③ it can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity. ④ it can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses. ⑤ It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so isotretinoin can also suppress tumorigenesis. ⑥ when subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role. Figure 1 Structure formula of Isotretinoin The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties	It is orange-red flake crystals obtained from isopropanol, melting point 174~175°C. UV maximal absorption: 354nm (ε39800). Acute toxicity LD50 (20 days) mice, rat (mg/kg): 904,901 intraperitoneal injections; 3389> 4000 oral administration.
Pharmacokinetics	This product is rapidly absorbed after oral administration. The plasma concentration reaches peak within 2 to 4 hours. However, oral administration has a low bioavailability which can be boosted by postprandial medication. It has a over 99% binding rate to the plasma protein. It is mainly metabolized in the liver or intestine wall. It enters into the enterohepatic circulation in the form of prototype and metabolites. Prototype drug without any changes is excreted from the feces while metabolite is excreted from the urine. The half life of elimination lasts 10 to 20 hours.
Uses	Isotretinoin is a vitamin A class drugs that It can rapidly and strongly inhibit the cell proliferation and differentiation process of skin glands cells. It has a high effect on severe nodular cystic acne. This product has a high gastrointestinal absorption, but invalid for topical administration. It is used for treating severe acnes which cannot be treated by other drugs. It also has some effects on treating cystic acne, the party of acne, rosacea, ichthyosis, follicular keratosis and pityriasis red hair and other skin diseases.
Indications	1. Isotretinoin should be the primary choice for treatment of refractory acne, especially for severe nodular, cystic, inflammatory acne patients to whom conventional therapy is ineffective. 2. Generalized Plana or verrucous epidermal dysplasia; 3. Skin disease of abnormal cornification; 4. Cutaneous lupus erythematosus; 5. lichen planus, atrophic lichen sclerosis.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Isotretinoin

Other Name:

Retinoic acid,13-cis-;13-cis-Retinoic acid;Neovitamin A acid;13-cis-Vitamin A acid;Ro 4-3780;13-cis-β-Retinoic acid;Isotretinoin;(13Z)-Retinoic acid;Accutane;Roaccutane;AGN 190013;Roaccutan;Accure;13-RA;Isotrex;IsotrexGel;cis-Retinoic acid;Absorica;Amnesteem;Claravis;Roacutan

CAS No.:

4759-48-2

Molecular Formula:

C20H28O2

InChIKeys:

InChIKey=SHGAZHPCJJPHSC-XFYACQKRSA-N

Molecular Weight:

300.44

Exact Mass:

300.44

EC Number:

225-296-0

HScode:

2942000000

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

37.3

XLogP3:

5.66

Appearance:

Yellow-orange to orange Fine Crystalline Powder

Density:

1.0±0.1 g/cm3

Melting Point:

174-175 °C

Boiling Point:

462.8°C at 760 mmHg

Flash Point:

350.6±11.0 °C

Refractive Index:

1.556

Water Solubility:

H2O: insoluble

Storage Conditions:

−20°C

Vapor Pressure:

1.02X10-7 mm Hg at 25 °C (est)

Toxicity:

LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)

PKA:

See More Isotretinoin Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment.
Response	P318 IF exposed or concerned, get medical advice. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

PRECAUTIONS FOR CYTOTOXIC AND HAZARDOUS DRUGS:/ Facilities (eg, shelves, carts, counters, and trays) for storing hazardous drugs are designed to prevent breakage and to limit contamination in the event of leakage. Bins, shelves with barriers at the front, or other design features that reduce the chance of drug containers falling to the floor should be used. Hazardous drugs requiring refrigeration should be stored separately from nonhazardous drugs in individual bins designed to prevent breakage and to contain leakage.

See More Isotretinoin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

19 Inquiries

Country	Product	Purchase Quantity	Date Posted
Croatia	Isotretinoin 4759-48-2	10 G	Nov 18, 2023
United States	isotretinoin	1 KG	Apr 8, 2026
Canada	Isotretinoin	50 G	Feb 19, 2026
United States	Isotretinoin	100 G	Jan 27, 2026
Czech	Isotretinoin	30 G	Dec 17, 2025
Russia	Isotretinoin Lidose 8 mg, 16 mg, 24 mg, 32 mg	500 KG	Nov 13, 2025
Czech	Isotretinoin	1 KG	Nov 8, 2025
Pakistan	Isotretinoin	10000 MG	Oct 25, 2025
Norway	Isotretinoin powder	10 G	Apr 13, 2025
Germany	Api Powder Isotretinoin 98% Accutane ISOTRETINOIN API POWDER	10 G	Apr 3, 2026
Australia	isotretinoin	10 G	Mar 10, 2026
United States	Isotretinoin	1 MT	Mar 5, 2026
Denmark	Isotretinoin powder	20 G	Nov 21, 2025
Pakistan	Isotretinoin	1 KG	Oct 27, 2025
United States	Isotretinoin	1 KG	Sep 2, 2024
United States	Isotretinoin	10 G	Jul 8, 2023
France	High purity isotretinoin powder for cystic acne	10 G	Nov 3, 2024
Pakistan	isotretranin	200 KG	Oct 17, 2024
Ireland	Isotretinoin powder	1 KG	Feb 28, 2024

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