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Isotretinoin

Isotretinoin structure

CAS No:
4759-48-2
Formula:
C20H28O2
Chemical Name:
Isotretinoin
Synonyms:
Retinoic acid,13-cis-;13-cis-Retinoic acid;Neovitamin A acid;13-cis-Vitamin A acid;Ro 4-3780;13-cis-β-Retinoic acid;Isotretinoin;(13Z)-Retinoic acid;Accutane;Roaccutane;AGN 190013;Roaccutan;Accure;13-RA;Isotrex;IsotrexGel;cis-Retinoic acid;Absorica;Amnesteem;Claravis;Roacutan
Categories:
Cosmetic Ingredient > Anti-sebum

Description

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.Target: RAR/RXRIsotretinoin has been the most effective and long-lasting drug for the treatment of severe acne for more than 30 years and can achieve long-term remission in 70-80% of patients after a single course. The new evidence-based European S3-guideline recommends the us

Retinoic acid is a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). It has a role as a human metabolite. It is a retinoid and an alpha,beta-unsaturated monocarboxylic acid. It is a conjugate acid of a retinoate.

Isotretinoin Basic Attributes

Molecular Weight：

300.44

Exact Mass：

300.44

EC Number：

225-296-0

HScode：

2942000000

Characteristics

PSA：

37.3

XLogP3：

5.66

Appearance：

Yellow-orange to orange Fine Crystalline Powder

Density：

1.0±0.1 g/cm3

Melting Point：

174-175 °C

Boiling Point：

462.8°C at 760 mmHg

Flash Point：

350.6±11.0 °C

Refractive Index：

1.556

Water Solubility：

H2O: insoluble

Storage Conditions：

−20°C

Vapor Pressure：

1.02X10-7 mm Hg at 25 °C (est)

Toxicity：

LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)

PKA：

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

61-36/37/38-20/21/22

safety instructions：

53-26-36/37/39-45-37/39

RTECS Number：

VH6440000

Marks：

Stability/Shelf Life：

Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201-P280-P305 + P351 + P338-P308 + P313

Hazard Statements：

H315-H319-H335-H360

Isotretinoin Use and Manufacturing

Uses

Used as a treatment for severe acne.Presently being studied in conjuction with the treatment of photoaged skin. It is a vitamin A drug, which has a strong and rapid function of inhibiting the proliferation and differentiation of skin gland cells, and is highly effective for severe nodular cystic acne. This product has better gastrointestinal absorption, but local medication is ineffective. It is used for severe acne, cystic acne, and party acne that are ineffective in the treatment of other drugs. It also has a certain effect on skin diseases such as rosacea, ichthyosis, follicular keratosis and pityriasis. Used for severe acne etc. Anti-keratosis drugs.

Manufacturing Info：

Retinoic acid, 13-cis-: ACTIVE

Computed Properties

Molecular Weight:300.4
XLogP3:6.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:300.208930132
Monoisotopic Mass:300.208930132
Topological Polar Surface Area:37.3
Heavy Atom Count:22
Complexity:567
Undefined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Promotes epidermal cell renewal, regulates epidermal cell proliferation and differentiation, loosens stratum corneum cells and makes them easy to fall off, helps remove acne, and inhibits the formation of new acne

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Isotretinoin gel
Ingredients	The main ingredient of this product is isotretinoin, also known as 13-cis retinoic acid. Its chemical name is: 3,7-dimethyl-9-{2,6,6-trimethyl-1-cyclohexene-1-yl}2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid. Its structural formula is: molecular formula C20H28O2, molecular weight 300.44.
Indication	1. There is a risk of increased photosensitivity when used with photosensitizing drugs. 2. When used with soap and other detergents, desquamation preparations (such as benzoyl peroxide, raclonidine, salicylic acid, sulfur, etc.), ethanol preparations, isotretinoin, etc., it may aggravate skin irritation or dryness, so it must be used with caution. 3. If you are using other drugs, you should consult a doctor or pharmacist before using this product.
Specifications	0.05%

Isotretinoin gel
Specifications	0.05%

Isotretinoin
Manufacturer	Harbin Center Pharmaceutical Co., Ltd.

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Registered Holders

BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
Active
HETERO DRUGS LTD

United Kingdom
Active
Siegfried PharmaChemikalien Minden GmbH

Germany
Active

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Guide of Isotretinoin

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Isotretinoin

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