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β-Nicotinamide Mononucleotide CAS:1094-61-7

Name: β-Nicotinamide Mononucleotide CAS:1094-61-7
Brand: Orient
SKU: pr2512181125
Price: 4 USD
Availability: InStock

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CAS No.:

1094-61-7

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-18

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Product Description
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Inquiry History

Description

Product Name:	β-Nicotinamide Mononucleotide
Synonyms:	BETA-NMN;BETA-NICOTINAMIDE MONONUCLEOTIDE;BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;B-NICOTINAMIDE MONONUCLEOTIDE;NMN;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;NICOTINAMIDE RIBOTIDE
CAS:	1094-61-7
MF:	C11H15N2O8P
MW:	334.22
EINECS:	214-136-5
Product Categories:	nicotinamide mononucleotide;Pharmaceuticals;Amines;Aromatics;Bases & Related Reagents;API;Intermediates & Fine Chemicals;Nicotine Derivatives;Nucleotides;BETA-NICOTINAMI;API;NMN;1094-61-7;nutrition supplement;pharmaceutical
Mol File:	1094-61-7.mol

β-Nicotinamide Mononucleotide Chemical Properties

Melting point	166 °C(dec.)
storage temp.	-20°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Yellow
Merck	13,6697
BRN	3570187
Stability:	Very Hygroscopic
Cosmetics Ingredients Functions	ANTIOXIDANT
InChI	InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/s3
InChIKey	DAYLJWODMCOQEW-TURQNECASA-N
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)([O-])=O)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O \|&1:1,2,3,11,r\|

Safety Information

WGK Germany	3
F	8-10-21
HS Code	2934999090

MSDS Information

β-Nicotinamide Mononucleotide Usage And Synthesis

Description	Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
Chemical Properties	White to Yellowish lyophilized powder
Uses	β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra. β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
Preparation	β-Nicotinamide mononucleotide is a NAD+intermediate. In recent years, the relation of NAD+metabolism and aging-associated disease is attracting attention from various research fields. Synthesis of β-nicotinamide mononucleotide (NMN) A solution of NAD (3.5 g, 5.28 mmol) and ZrCl4(6.15 g, 26.4 mmol) in 500 ml water was stirred at 50°C for 30 min. The hydrolysis was monitored by TLC (SiO2EtOH/ 1 M NH4Ac [7 : 3]). The reaction was quenched with 245mL of a 0.5 M solution of Na3PO4. After adjusting to pH 7 with a 2 M solution of HCl, a white precipitate was formed. The suspension was centrifuged 8 min,1,000rpm, the supernatant was collected and the pellet was washed two times with 200 mL water. The combined supernatants wereconcentrated to 1/3 of its volume on a rotary evaporator. The remaining solution was purified with a column filled with Dowex 50WX8 (100-200 mesh, H+-Form, column-material: 2.5 x 30 cm). The column was loaded with 1.5 L5 % HCl and equilibrated with1.5L millipore water until pH 5 was reached. 100 mL of the concentrated solution was loaded on the ion exchange column and eluted with Milliporewater. The first cleavage product eluted was NMN (615 mg, 1.84 mmol,yield:35 %) and yielded a colorless solid after evaporation of the solvent, followed by AMP. 1H NMR (500MHz, D2O)δ: 9.48 (s, 1 H), 9.31 (d,J= 6.2 Hz, 1 H), 9.00 (d,J= 8.2 Hz, 1 H), 8.32 (dd,J= 8.2, 6.2 Hz, 1 H), 6.24 (d,J=5.4 Hz, 1 H), 4.68-4.64 (m, 1 H), 4.58 (t, 1 H), 4.48-4.45 (m, 1 H), 4.36–4.14 (m,J= 12.0, 2 H). 13C NMR (75 MHz, d2o) δ: 165.50, 145.65, 142.15, 139.53, 133.62, 128.19, 99.65, 87.18, 87.06, 77.42, 70.71, 63.89, 63.82. 31P NMR (202 MHz, D2O)δ:-0.03
Definition	ChEBI: β-Nicotinamide Mononucleotide is a condensation product of nicotinamide and ribose 5-phosphate, in which the nitrogen of nicotinamide is linked to the (β) c-l of the ribose. NMN zwitterion is a nicotinamide mononucleotide. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate base of a NMN(+). It is a conjugate acid of a NMN(-).
Application	β-Nicotinamide mononucleotide (NMN) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice . It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. It is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
benefits	As one of the primary precursors of NAD+ and intermediaries in NAD+ biosynthesis, NMN is as essential as NAD+ in the body’s proper functioning of cells. NAD helps cells regulate a number of essential functions that help keep your cells running smoothly, including:energy metabolism, DNA repair, gene expression, and cellular stress responses.
General Description	β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
Biochem/physiol Actions	In light of metabolic control mechanisms and many reports on β-Nicotinamide Mononucleotide (β-NMN), β-NMN is likely to be more effective as an NAD+ precursor than Nam. Research has compared the blood total NAD (NAD++NADH) and urinary excretion amounts of NAD+ catabolites in β-NMN- and Nam-administered rats. The concentration of blood total NAD and liver total NAD showed no significant differences among the three groups. However, when examining the kinetics of the urinary excretion, the urinary excretion of the SUM was lower in the β-NMN group than in the Nam group at 3-6 h after the administration. Moreover, the percentage of the urinary SUM was much lower in the β-NMN group than in the Nam group at 3-6 h. This result suggests that β-NMN is retained in the body for longer than Nam is. In addition, this result means that β-NMN has a higher turnover of salvage biosynthesis of NAD+ than Nam does. The resulting phenomenon accelerates the turnover of salvage biosynthesis of NAD+, which activates the SIRT1 reaction because SIRT1 (histone deacetylase) needs NAD+. Deacetylated histone molecules induce DNA silencing, contributing to anti-aging and longevity. When β-NMN is intraperitoneally injected, β-NMN is dephosphorylated in the blood to form Nam riboside (NR), which is then transported into the cells. NR is re-phosphorylated to form β-NMN, which is then synthesized to NAD+ in the nucleus. In contrast to Nam, which is controlled at the Nam→β-NMN reaction, the β-NMN biosynthesis pathway is not regulated[1].

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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Certificates

Basic Info

Product Name:

Nicotinamide mononucleotide

Other Name:

Pyridinium,3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-,inner salt;Pyridinium,3-carbamoyl-1-β-D-ribofuranosyl-,hydroxide,5′-(dihydrogen phosphate),inner salt;Pyridinium,3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-,hydroxide,inner salt;3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide,5′-phosphate,inner salt;Nicotinamide mononucleotide;Nicotinamide ribonucleotide;NMN;Nicotinamide ribotide;β-NMN;Nicotinamide ribonucleoside 5′-phosphate;NMN (mononucleotide);β-D-NMN;27626-81-9;1140909-84-7

CAS No.:

1094-61-7

Molecular Formula:

C11H15N2O8P

InChIKeys:

InChIKey=DAYLJWODMCOQEW-TURQNECASA-N

Molecular Weight:

334.22

Exact Mass:

334.056610

EC Number:

214-136-5

UNII:

2KG6QX4W0V

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

166

XLogP3:

-3.5

Storage Conditions:

2-8°C

Collision Cross Section:

165.2 Å² [M]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|165.2 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|167.13 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|166 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|165.8 Å² [M+H]+

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Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nicotinamide mononucleotide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

60 Inquiries

Country	Product	Purchase Quantity	Date Posted
Australia	NMN β-Nicotinamide Mononucleotide 1094-61-7 99.5% Uthever	50 KG	Nov 17, 2023
United Kingdom	NMN β-Nicotinamide Mononucleotide 1094-61-7 99.5% Uthever	100 MT	Aug 10, 2023
Philippines	β-NMN bulk powder 1094-61-7 Purity 99.9% food grade Beta Nicotinamide Mononucleotide powder	500 G	Jul 17, 2025
India	Beta-Nicotinamide Mononucleotide	1 KG	Jan 19, 2026
Russia	NMN	10 KG	Aug 4, 2023
India	NMN	1.00 KG	Dec 21, 2023
India	Nicotinamide mononucleotide	50 G	Apr 8, 2026
United States	NMN	100 G	Mar 14, 2026
India	Niacinamide	75.00 KG	Feb 25, 2026
Australia	NMN	1 KG	Feb 21, 2026
Indonesia	Nicotinamide mononucleotide NMN	1 KG	Oct 13, 2025
Australia	NMN	1 KG	Nov 1, 2024
United States	β-Nicotinamid Mononucleotide	1 KG	Sep 26, 2024
South Korea	b-NMN	1 KG	May 30, 2024
Vietnam	NMN	1 MT	May 24, 2024
United States	NMN	1 MT	Mar 7, 2024
Australia	NMN	50 KG	Dec 12, 2023
Peru	NMN	1 KG	Nov 29, 2023
Mexico	NMN	5 KG	Oct 25, 2023
Romania	NMN	1 KG	Sep 5, 2023

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