Wholesale Kpv 99% Pure Custom Synthetic Immunity Boost Factory CAS 67727-97-3

1.  Description

     Chemical Properties: KPV is a linear tripeptide compound with the amino acid sequence Lys-Pro-Val (lysine-proline-valine), existing in acetate salt form (enhancing water solubility and stability). Its core targets include skin inflammation-related receptors (e.g., MC1R) and pro-inflammatory factor signaling pathways (TNF-α, IL-6 pathways). Chemically stable, resistant to hydrolysis in neutral to weakly acidic environments (pH 5.0-7.0), with superior resistance to peptidase degradation compared to long-chain peptides. Exhibits excellent compatibility with cosmetic/pharmaceutical active ingredients such as niacinamide, salicylic acid, and ceramides. Molecular weight: 375.45 Da.

     Physical Properties: KPV appears as a white to off-white crystalline powder at room temperature, odorless and tasteless. It exhibits excellent water solubility (solubility ≥50 mg/mL), dissolving rapidly in pure water, saline, phosphate-buffered saline (PBS), and aqueous matrices like glycerol or propylene glycol. It is slightly soluble in ethanol and insoluble in non-polar solvents such as ether or petroleum ether. Store at -20°C in a dry, sealed container protected from light. Avoid repeated freeze-thaw cycles. Research-grade/application-grade products have ≥98% purity (HPLC-assayed), ≤1.0% impurities, and are free of endotoxins (≤0.05 EU/mg) and heavy metals (lead, mercury, arsenic, etc. ≤0.1 ppm).

     Source and Preparation: KPV naturally occurs in human skin tissue, blood, and cerebrospinal fluid, serving as the core active fragment responsible for α-MSH's anti-inflammatory effects. Industrially synthesized via precise solid-phase peptide synthesis using high-purity L-amino acids as raw materials. The process involves condensation, deprotection, peptide chain assembly, and acetate modification, culminating in high-purity product purification via high-performance liquid chromatography (HPLC). Reaction conditions are strictly controlled throughout synthesis to ensure structural integrity and biological activity. Product quality is validated via mass spectrometry (MS) and amino acid sequence analysis, with no residual chemical synthesis byproducts.

2.  Application

     Anti-inflammatory Acne-Fighting Products: KPV is suitable for oily, acne-prone skin and inflammatory acne conditions. It is used to develop acne-fighting serums, anti-inflammatory gels, and acne repair essences. It can be applied directly to inflamed acne areas to relieve redness, swelling, and stinging, while reducing the recurrence of inflammatory breakouts. Formulation Logic: KPV + Salicylic Acid (mild concentration 0.5%-1%) + Niacinamide (2%-3%). KPV provides anti-inflammatory soothing, salicylic acid unclogs pores, and niacinamide regulates sebum production. This synergistic approach achieves triple effects: anti-inflammatory + oil control + acne reduction.

     Sensitive Skin & Barrier Repair Products: Targeting seasonal sensitivity, rosacea, and corticosteroid-dependent dermatitis. Used in soothing repair creams, redness-relief serums, and anti-inflammatory masks. Formulated with minimal, gentle ingredients (no fragrances or alcohol), combined with ceramides and panthenol to rapidly alleviate redness, dryness, itching, and stinging while strengthening the skin barrier.

     Post-Procedure/Peel Recovery Products: KPV complements treatments like chemical peels and photofacials, enabling the development of recovery freeze-dried powders and soothing sprays. KPV suppresses post-procedure inflammation, shortens redness recovery time, and prevents post-inflammatory hyperpigmentation. Combined with ectoin and centella asiatica extract, it enhances recovery efficiency.

     Scalp Anti-Inflammatory Care Products: For individuals with seborrheic dermatitis, scalp itchiness, or dandruff, used in developing anti-inflammatory shampoos and scalp repair serums. KPV suppresses scalp inflammation, regulates the scalp microenvironment, and reduces dandruff production. When combined with tea tree oil and pyrithione zinc, it enhances oil control and itch relief.

3. Main Efficacy

     Powerful Targeted Anti-Inflammatory Effects: KPV's core mechanism involves specifically binding to the MC1R receptor on skin cell surfaces, inhibiting the transcription and release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) to block inflammatory chain reactions; Simultaneously downregulates cyclooxygenase-2 (COX-2) activity to reduce prostaglandin production. This accelerates relief from inflammatory acne and sensitive skin redness by 2-3 times compared to traditional anti-inflammatory ingredients (e.g., dipotassium glycyrrhizate), without hormonal side effects.

     Antimicrobial Modulation: KPV selectively inhibits acne-causing bacteria like Propionibacterium acnes and Staphylococcus aureus by disrupting bacterial cell membrane permeability to suppress proliferation. It preserves beneficial skin microbiota balance, avoiding the dysbiosis caused by broad-spectrum antimicrobials, making it suitable for long-term acne care.

     Skin Barrier Repair: KPV promotes proliferation and differentiation of skin keratinocytes, increasing epidermal thickness. simultaneously stimulates ceramide and keratin synthesis to reconstruct the skin's lipid barrier, reducing transepidermal water loss (TEWL). For barrier-damaged skin (e.g., post-chemical peels, steroid-damaged skin), repair rates exceed 40% within 28 days, enhancing tolerance to external irritants.

     Immune Modulation & Anti-Pigmentation Benefits: KPV regulates the skin's innate immune response, balances immune cell activity, and reduces skin damage caused by excessive inflammation. It also inhibits post-inflammatory hyperactivation of melanocytes, diminishing pigmentation and preventing brown acne marks left after inflammatory acne or eczema healing, achieving a synergistic “anti-inflammatory + mark-fading” effect.

     Safety Advantages: As an endogenous tripeptide fragment, KPV exhibits exceptional biocompatibility with no immunogenicity, causing no allergic or rejection reactions. High-risk irritation patch testing (HRIPT) confirms non-sensitizing properties, while cytotoxicity testing (MTT) shows >98% skin cell viability at concentrations ≤5 μmol/L. Long-term use carries no side effects such as hormone dependency or skin atrophy, making it suitable for sensitive skin, pregnant women, and other delicate skin types. Compliance meets EU CosIng and China's “List of Cosmetic Ingredients in Use” requirements.