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Benfotiamine CAS:22457-89-2

Name: Benfotiamine CAS:22457-89-2
Brand: Orient
SKU: pr2512241510
Price: 4 USD
Availability: InStock

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CAS No.:

22457-89-2

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Benfotiamine
Synonyms:	benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester
CAS:	22457-89-2
MF:	C19H23N4O6PS
MW:	466.45
EINECS:	245-013-4
Product Categories:	API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds;22457-89-2
Mol File:	22457-89-2.mol

Benfotiamine Chemical Properties

Melting point	165 C
Boiling point	745.1±70.0 °C(Predicted)
density	1.444±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
pka	1.84±0.10(Predicted)
form	Solid
color	White to Off-White
Merck	14,1041
Stability:	Hygroscopic
InChIKey	BTNNPSLJPBRMLZ-GHRIWEEISA-N
SMILES	C(C1=CN=C(C)N=C1N)N(C=O)C(C)=C(CCOP(O)(O)=O)SC(C1C=CC=CC=1)=O
LogP	-2.814 (est)
CAS DataBase Reference	22457-89-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
WGK Germany	2
RTECS	DH6910000
HS Code	2933.59.8000

MSDS Information

Benfotiamine Usage And Synthesis

Chemical Properties	crystals
Originator	Biotamin,Sankyo
Uses	S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.
Uses	Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
Definition	ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process	28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Benfotiamine

Other Name:

Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester;Benzoic acid,thio-,S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester);Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester;Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-,S-benzoate O-(dihydrogen phosphate);N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate;Benfotiamine;Benzoylthiamine monophosphate;Benzoylthiamine O-monophosphate;S-Benzoylthiamine monophosphate;S-Benzoylthiamine O-monophosphate;Biotamin;BTMP;Nitanevril;Neurostop;Vitanevril;Berdi;Betivina;Bietamine;Tabiomyl;Benfothiamine;8088CB;Milgamma;137-74-6

CAS No.:

22457-89-2

Molecular Formula:

C19H23N4O6PS

InChIKeys:

InChIKey=BTNNPSLJPBRMLZ-UHFFFAOYSA-N

Molecular Weight:

466.45

Exact Mass:

466.45

EC Number:

245-013-4

UNII:

Y92OUS2H9B

DSSTox ID:

DTXSID3045433

ATC Code:

A - Alimentary tract and metabolism

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

181

XLogP3:

3.84720

Appearance:

shinning black powder

Density:

1.4±0.1 g/cm3

Melting Point:

165 °C (decomp)

Boiling Point:

745.1°C at 760 mmHg

Flash Point:

404.4±35.7 °C

Refractive Index:

1.645

Storage Conditions:

2-8°C

Vapor Pressure:

2.55E-23mmHg at 25°C

See More Benfotiamine Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Benfotiamine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Benfotiamine 98% white powder 22457-89-2 Senwayer	5 MT	Sep 28, 2023
Brazil	BENFOTIAMINA	20.00 KG	Jun 28, 2023
Mexico	Benfotiamine	1 KG	Jun 18, 2025

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