99% EP STandard Quetiapine fumarate White Raw Power With Best Price and Fast Delivery

Quetiapine Fumarate More Info

Quetiapine Fumarate is an atypical antipsychotic medication, formulated as the fumarate salt of quetiapine, with the CAS Registry Number 111974-72-2. Its molecular structure is based on a dibenzothiazepine core, which differentiates it chemically from other major classes of antipsychotics. The formation of the fumarate salt enhances the stability, crystallinity, and solubility of the base compound for pharmaceutical manufacturing. It is typically supplied as a white to off-white crystalline powder.

The drug's mechanism of action is complex and involves antagonism at multiple neurotransmitter receptors, primarily within the dopamine and serotonin pathways. It exhibits high affinity as an antagonist for serotonin 5-HT2A receptors and dopamine D2 receptors, with a generally faster dissociation from D2 receptors than typical antipsychotics. It also has notable antagonistic activity at histamine H1 and adrenergic α1 and α2 receptors. This broad receptor profile is responsible for its efficacy in treating both positive and negative symptoms of psychosis, as well as its distinct side effect profile.

Quetiapine is approved for a wide range of psychiatric conditions. Its primary uses include the treatment of schizophrenia, bipolar disorder (for both manic and depressive episodes), and as an adjunctive therapy for major depressive disorder. It is also commonly prescribed off-label for conditions such as generalized anxiety disorder, insomnia, and agitation. The extended-release formulation allows for once-daily dosing, improving adherence, while the immediate-release form allows for dose titration and management of acute symptoms.

The medication is administered orally in tablet form, available in both immediate-release and extended-release formulations. Dosage varies significantly based on the indication, ranging from low doses for adjunctive depression or sleep to much higher doses for acute psychosis or mania. It is extensively metabolized in the liver, primarily by the cytochrome P450 3A4 enzyme system, leading to numerous clinically significant drug-drug interactions with inducers or inhibitors of this pathway.

The safety profile of quetiapine is defined by its receptor-binding properties. Common side effects include sedation (due to H1 antagonism), orthostatic hypotension and dizziness (due to α1 antagonism), dry mouth, and weight gain. Metabolic effects such as dyslipidemia and insulin resistance are significant long-term concerns requiring monitoring. It carries a lower risk of extrapyramidal side effects and tardive dyskinesia compared to typical antipsychotics but is associated with dose-dependent QTc interval prolongation. The risk of overdose is considered significant, particularly in combination with other CNS depressants.

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Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
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Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

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Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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