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Best Quality 99% Olaparib/AZD2281 CAS:763113-22-0 for Anti Ovarian Cancer buy - image1

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Best Quality 99% Olaparib/AZD2281 CAS:763113-22-0 for Anti Ovarian Cancer buy - image4

Best Quality 99% Olaparib/AZD2281 CAS:763113-22-0 for Anti Ovarian Cancer

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Unit Price:

$2-2.5/G FOB

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CAS No.:

763113-22-0

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1g/bag, 20g/bag, 50g/bags or other quantities

Price valid (until):

2027-04-30

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Olaparib
CAS number	763113-22-0
Synonym	Olaparib； 763113-22-0 ； AZD2281 ； AZD-2281
Description	Description: Olaparib is an innovative pharmaceutical compound that belongs to the class of drugs known as PARP inhibitors. It is widely recognized in the medical field for its application in the treatment of certain types of cancers. Primarily, Olaparib is utilized in the management of ovarian, breast, pancreas, and prostate cancers that are predisposed by specific genetic mutations. The effectiveness of Olaparib in targeting these cancer types offers significant hope and therapeutic options for both patients and healthcare providers. Mechanism of Action : The mechanism by which Olaparib exerts its therapeutic effect is rooted in its ability to inhibit the poly (ADP-ribose) polymerase (PARP) enzyme. PARP plays a critical role in the repair of single-strand DNA breaks through the base excision repair pathway. By inhibiting this enzyme, Olaparib induces a state of "synthetic lethality" in cells deficient in homologous recombination repair (HRR), particularly those harboring mutations in the BRCA1 or BRCA2 genes. In healthy cells, DNA damage can be repaired effectively due to functional HRR pathways. However, in cancer cells deficient in HRR, such as those with BRCA mutations, the inhibition of PARP leads to the accumulation of DNA damage, subsequent genomic instability, and ultimately cancer cell death. This selective targeting of cancer cells while sparing normal cells forms the basis of Olaparib's therapeutic index. Usage: Olaparib is primarily indicated for patients with advanced ovarian cancer who have been treated with other chemotherapeutic agents previously. It serves as a maintenance therapy following platinum-based chemotherapy, particularly where the presence of BRCA1 or BRCA2 mutations has been identified. Additionally, it finds use in patients with metastatic breast cancer, pancreatic cancer, and prostate cancer who have similar genetic predispositions. The administration of Olaparib is typically oral, and it is formulated into tablet or capsule form to ensure ease of administration and patient compliance. The dosage and duration of treatment with Olaparib are determined based on various factors, including the type of cancer, the presence of genetic mutations, and the patient's overall health status. Chemical Classification: Chemically, Olaparib is classified as a benzimidazole carboxamide. Its molecular structure is characterized by the presence of nitrogen heterocycles, which are integral to its ability to interact specifically with the PARP enzyme. This distinct chemical classification underpins its mechanism as a PARP inhibitor, differentiating it from other anti-cancer drugs with broader mechanisms of action. Additional Information: One of the pivotal aspects of using Olaparib in clinical settings is the necessity for genetic testing prior to treatment initiation. Determining the presence of BRCA1 or BRCA2 mutations is vital since it directly influences the drug's efficacy. Such personalized medicine approaches not only enhance the therapeutic outcomes but also contribute to a deeper understanding of cancer biology in individual patients. Olaparib has been subject to extensive clinical trials which have demonstrated its efficacy and safety profile across diverse patient populations. Due to its targeted mechanism, Olaparib is generally well-tolerated, with a side effect profile that is more favorable compared to traditional chemotherapeutic agents. Commonly reported adverse effects include nausea, fatigue, anemia, and vomiting, which are typically manageable under clinical guidance. The impact of Olaparib extends beyond individual patient care; it has paved the way for the development and approval of other PARP inhibitors, broadening the horizon of cancer therapeutics. Furthermore, research is ongoing to explore Olaparib’s potential in combination with other cancer treatments, such as immunotherapies and radiotherapy, to enhance its antitumor effects. In conclusion, Olaparib represents a significant advancement in the realm of targeted cancer therapies. Its ability to exploit the defective DNA repair mechanisms in cancer cells with BRCA mutations exemplifies the precision medicine approach. By continuing to refine its applications and understanding its full potential, Olaparib continues to be at the forefront of redefining cancer treatment paradigms, offering hope and improved quality of life for patients battling these challenging malignancies.
Structure
Molecular Formula	C ₂₄ H ₂₃ FN ₄ O ₃
Molecular Weight	434.46 g/mol
Appearance	White or almost white crystalline powder
Quality Standard	USP EP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Olaparib

Other Name:

1(2H)-Phthalazinone,4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-;Piperazine,1-(cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]-;4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone;Olaparib;KU 59436;AZD 2281;KU 0059436;4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;Lynparza;AZD2281;AZD-2281;937799-91-2;1021843-02-6;894104-70-2

CAS No.:

763113-22-0

Molecular Formula:

C24H23FN4O3

InChIKeys:

InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N

Molecular Weight:

434.469

Exact Mass:

434.46

EC Number:

1308068-626-2

UNII:

WOH1JD9AR8

NSC Number:

747856

NCI Thesaurus Code:

C71721

ATC Code:

L01XX46|L - Antineoplastic and immunomodulating agents

HScode:

29339900

Categories:

Antineoplastic Agents

Characteristics

PSA:

82.1

XLogP3:

1.9

Density:

1.4±0.1 g/cm3

Refractive Index:

1.702

See More Olaparib Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Olaparib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	OLAPARIB (FORM A)	5 G	Nov 4, 2025
India	Olaparib	2 G	Jan 9, 2024

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