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N-Acetyl-L-cysteine CAS:616-91-1

Name: N-Acetyl-L-cysteine CAS:616-91-1
Brand: Orient
SKU: pr2512292310
Price: 4 USD
Availability: InStock

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CAS No.:

616-91-1

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-29

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	N-Acetyl-L-cysteine
Synonyms:	(S)-ALPHA-AMINO-2-NAPHTHALENEPROPIONIC ACID;RARECHEM BK PT 0097;N-ACETYL CYSTEINE;N-ACETYL-3-MERCAPTOALANINE;N-ACETYL-L-(+)-CYSTEINE;N-ACETYL-L-CYSTEINE;N-ALPHA-ACETYL-L-CYSTEINE;AC-L-CYS-OH
CAS:	616-91-1
MF:	C5H9NO3S
MW:	163.19
EINECS:	210-498-3
Product Categories:	Amino Acids & Derivatives;Miscellaneous Compounds;Phenylalanine analogs and other aromatic alpha amino acids;Amino ACIDS SERIES;MUCOMYST;amino;Amino Acids;Ac-Amino Acids;Amino Acids (N-Protected);Antioxidant;Biochemistry;Nutritional Supplements;N-Acetyl-Amino acid series;Amino acid;Cysteine [Cys, C];Pharmaceutical Intermediates;bc0001;616-91-1
Mol File:	616-91-1.mol

N-Acetyl-L-cysteine Chemical Properties

Melting point	106-108 °C(lit.)
alpha	-35.1 ºC (c=2,H2O)
Boiling point	407.7±40.0 °C(Predicted)
bulk density	730kg/m3
density	1.249 (estimate)
vapor pressure	0Pa at 20℃
refractive index	24 ° (C=JPC Method)
storage temp.	2-8°C
solubility	H₂O: 100 mg/mL with heating
form	Solid
pka	pK1: 9.52 (30°C)
color	White
PH	1.5-2.5 (20°C, 100g/L in H2O)
biological source	rabbit
Water Solubility	Soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether.
Merck	14,88
BRN	1724426
Specific Activity	≥20units/μg protein
Stability:	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	ANTIOXIDANT SKIN CONDITIONING
InChIKey	PWKSKIMOESPYIA-BYPYZUCNSA-N
LogP	-0.6 at 23℃
CAS DataBase Reference	616-91-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetylcysteine(616-91-1)
EPA Substance Registry System	L-Cysteine, N-acetyl- (616-91-1)

Safety Information

Risk Statements	36/37/38
Safety Statements	22-24/25
WGK Germany	3
RTECS	HA1660000
F	10-23
TSCA	Yes
HS Code	29309016
Hazardous Substances Data	616-91-1(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 5050 mg/kg (Goldenthal)

MSDS Information

N-Acetyl-L-cysteine Usage And Synthesis

Description	N-Acetyl-L-cysteine is an N-acetylated derivative of cysteine, which contains a sulfhydryl group in the molecule, which can break the disulfide bond (-S-S-) of the mucin peptide bond, so that the mucin chain becomes a small molecule peptide chain, reducing The viscosity of mucin, so It is a dissolving drug for mucus in mucus, purulent sputum and respiratory tract.
Chemical Properties	N-Acetyl-L-cysteine is a white crystalline powder that has a garlic-like smell and sour taste. It is hygroscopic, and can dissolve in water or ethanol, but is insoluble in ether and chloroform. This substance is also acidic in aqueous solution, with a pH range of 2-2.75 for a concentration of 10g/L H2O.
Originator	Mucomyst ,Mead Johnson,US
Uses	A metabolite of Methyl Isocyanate. N-Acetyl-L-cysteine, by itself a poor scavenger of oxidants, is converted inside cells to yield sulfane sulfur species, which are very potent scavengers of oxidants.
Uses	An antioxidant mucolytic acetylated amino acid. N-acetyl-l-cysteine (NAC) is a derivative of the dietary amino acid l-cysteine. NAC has a high affinity for lung tissue, which it supports through mucolytic and antioxidant action. NAC also enhances glutathione production and plays a role in heavy metal detoxification.
Definition	ChEBI: N-Acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. It is a pharma ceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.
Manufacturing Process	To a suspension of 35.2 grams (0.2 mol) of L-cysteine hydrochloride monohydrate stirred in a reaction vessel containing 87 ml of 91% aqueous tetrahydrofuran under a nitrogen atmosphere there is added 54.4 grams (0.4 mol) of sodium acetate trihydrate. The mixture is stirred for 20 minutes at room temperature to insure neutralization of the hydrochloride salt resulting in the formation of a suspension of equimolar amounts of cysteine and sodium acetate. The mixture is then chilled to 3-6°C by external cooling and 20 ml (20.8 grams, 0.21 mol) of acetic anhydride is added thereto in dropwise fashion with cooling in the above range. The resulting mobile suspension is stirred for 6 hours at room temperature, allowed to stand overnight, and finally heated at reflux (72°C) for 4 hours. The resulting suspension of sodium N-acetyl-Lcysteinate is then neutralized by treatment at 5-10°C with 8 grams of hydrogen chloride. Resulting sodium chloride is removed by filtration and the product is isolated by distilling the solvent from the filtrate in vacuum and crystallizing the residue from 35 ml of water, yield 26.3 grams (80.6%) of Nacetylcysteine as a white solid, MP 109-110°C.
Brand name	Acetadote (Cumberland); Mucomyst (Apothecon); Mucosil (Dey).
Therapeutic Function	Expectorant
benefits	n-acetyl-l-cysteine is a skin conditioner. It may also be used as an anti-aging ingredient given a demonstrated ability to regulate skin atrophy and reduce the appearance of fine lines and wrinkles.
General Description	N-Acetyl-L-cysteine is the N-acetyl derivative of the amino acid Lcysteine, and is a precursor in the formation of the antioxidant glutathione in the body. The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. This compound is sold as a dietary supplement commonly claiming antioxidant and liver protecting effects. It is used as a cough medicine because it breaks disulfide bonds in mucus and liquefies it, making it easier to cough up. It is also this action of breaking disulfide bonds that makes it useful in thinning the abnormally thick mucus in cystic and pulmonary fibrosis patients. In India it is marketed by Intas under the trade name 'Efetil'.
Biochem/physiol Actions	Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Mechanism of action	N-Acetyl-L-cysteine is a kind of membrane penetrating antioxidant. It has anti-inflammatory activity through regulating the activation of NF-KB and HIF-1α; as well as modulation of ROS. It can penetrate across the membrane, replenishes intracellular and glutathione and GSH to help the cell fight against oxidative stress. In addition to its antioxidant action, NAC acts as a vasodilator by facilitating the production and action of nitric oxide. This property is an important mechanism of action in the prophylaxis of contrast-induced nephropathy and the potentiation of nitrate-induced vasodilation (Millea 2009).
Side effects	At dosages of 1,200 mg twice daily or lower, N-acetylcysteine is well tolerated. At these dosages, side effects are unusual, but may include nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation. www.aafp.org

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

N-Acetyl-L-cysteine

Other Name:

(S)-ALPHA-AMINO-2-NAPHTHALENEPROPIONIC ACID;RARECHEM BK PT 0097;N-ACETYL-3-MERCAPTOALANINE;N-ACETYL-L-(+)-CYSTEINE;N-ACETYL-L-CYSTEINE;N-ALPHA-ACETYL-L-CYSTEINE;AC-L-CYS-OH;ACETYL-L-CYSTEINE

CAS No.:

616-91-1

Molecular Formula:

C5H9NO3S

InChIKeys:

PWKSKIMOESPYIA-BYPYZUCNSA-N

Molecular Weight:

163.19

BRN:

1724426

EC Number:

210-498-3

TSCA:

TSCA listed

Color/Form:

White

HScode:

29309016

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.249 (estimate)

Melting Point:

106-108 °C(lit.)

Boiling Point:

407.7±40.0 °C(Predicted)

Refractive Index:

24 ° (C=JPC Method)

Water Solubility:

Soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether.

Vapor Pressure:

0Pa at 20℃

Toxicity:

LD50 orally in rats: 5050 mg/kg (Goldenthal)

PH:

1.5-2.5 (20°C, 100g/L in H2O)

PKA:

pK1: 9.52 (30°C)

Critical Temperature & Pressure:

2-8°C

See More N-Acetyl-L-cysteine Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Unopened vials of acetylcysteine sodium solution should be stored at 15-30 deg C. Following exposure to air, solutions should be stored at 2-8 deg C to retard oxidation and should be used within 96 hr.

See More N-Acetyl-L-cysteine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

23 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	N-Acetyl-L-cysteine NAC CAS 616-91-1 with Factory Price	25 KG	Nov 2, 2023
Singapore	2-ACETAMIDO-3-MERCAPTOPROPIONIC ACID	4000 KG	Sep 18, 2024
Pakistan	N-ACETYL-L-CYSTEINE	1 KG	Jan 15, 2026
Turkey	N-Acetyl-cysteine	300 MT	Apr 14, 2026
Romania	N-acetyl cysteine	1 KG	Mar 25, 2026
Switzerland	N-Acetyl-L-Cysteine	250 KG	Jul 18, 2025
Malaysia	N-Acetyl-cysteine	2 MT	May 11, 2025
Australia	N-Acetyl-L-Cysteine	5 KG	Sep 13, 2024
India	N-Acetyl Cysteine	50.00 KG	Feb 19, 2024
Brazil	N-Acetyl-L-Cysteine	1000 KG	Mar 29, 2026
Brazil	N-Acetylcysteine (NAC)	2000 MT	Sep 16, 2025
Pakistan	ACETYLCYSTEINE	50 KG	Mar 25, 2025
United States	N-Acetyl-L-Cysteine	750000 KG	Mar 4, 2025
Netherlands	N-Acetyl-L-Cysteine	25 KG	Jan 26, 2025
India	N-Acetyl-L-cysteine/acetylcysteine	6 MT	Jun 7, 2024
India	N-Acetyl-L-cysteine/acetylcysteine	6.5 MT	Apr 26, 2024
Egypt	N-Acetyl-L-cysteine	1.00 MT	Sep 19, 2023
Poland	N-acetylcysteine	200 KG	Nov 16, 2023
United States	N-acetyl cysteine	100 KG	Nov 2, 2023
Australia	N-Acetyl-L-Cysteine 99.9% HAIDE Biotech	10 KG	Oct 4, 2023

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