Name: Hydroxypropyl beta cyclodextrin

Appearance: White powder

CAS: 128446-35-5

Molecular formula :C42H_70-nO₃₅(C₃H₈O₂)n

Molecular weight: 1134.98+58n

Package: 10kg/drum

Application

Phytosterol is a natural active substance, which can reduce the content of total cholesterol in serum and the level of low-density lipoprotein cholesterol. Using hydroxypropyl beta cyclodextrin inclusion phytosterols, the nonpolar cavity for sterol nonpolar carbon chain section provides a good space, then the inherent hydroxyl groups of the sterol part exposed side, and inherent in cyclodextrin hydroxyl increased overall hydrophilic properties, thus improving the sterol solubility in water.

FAQ

1. What is the minimum order quantity of this product?

The MOQ is 1KG.

2.Can you provide free samples?

We supply you 50 grams for you test,but you need to pay express charge.

3.What kind of payment can you accept?

T/T payment.

(2-Hydroxypropyl)-β-cyclodextrin

Description

(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.

In Vitro

Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin.

In Vivo

(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects.