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Raw material TFFH

Name: Raw material TFFH
Brand: Hyper Chem
SKU: pr2601131297
Price: 100 USD
Availability: InStock

2 Inquiries

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CAS No.:

164298-23-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2026-02-13

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	TFFH
CAS number	164298-23-1
Description	TFFH, short for Tetramethylfluoroformamidinium Hexafluorophosphate, is a non-hygroscopic, air-stable white crystalline salt widely used as a coupling and fluorinating reagent in organic synthesis, especially peptide synthesis.
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

TFFH More Info

Basic Information

Chemical Name: Tetramethylfluoroformamidinium Hexafluorophosphate

Abbreviation: TFFH

CAS Number: 84573-16-0

Molecular Formula: C₅H₁₂F₇N₂P

Molecular Weight: 264.13 g/mol

Structural Formula: [ (CH₃)₂N-C(F)=N(CH₃)₂ ]⁺ PF₆⁻

Physical Properties: Non-hygroscopic, white crystalline solid, stable under ambient conditions, with a decomposition temperature of 370°C (DSC analysis shows an exothermic heat of 146 J/g)

Discovery and Development

TFFH was first introduced by Carpino and El-Faham in 1995 as a safe and user-friendly alternative to corrosive cyanuric fluoride, initially for peptide synthesis applications.

Key Applications

Peptide Synthesis: It serves as an excellent coupling reagent for both solution and solid-phase peptide synthesis, especially for sterically hindered amino acids (e.g., Aib-containing peptides). In the presence of DIPEA, it converts Fmoc-amino acids to acid fluorides (1842 cm⁻¹ IR absorption) for efficient amide bond formation.

Organic Synthesis: It is used to prepare acid fluorides, hydrazides, azides, anilides, alcohols, and hydroxamic acids from carboxylic acids. Combined with benzyltriphenylphosphonium dihydrogen trifluoride (PTF), it converts carboxylic acids to alcohols with high yields.

Deoxofluorination: It enables deoxofluorination reactions, which can be scaled up to over 100 grams, suitable for industrial applications.

Handling and Advantages

Handling: It is non-hygroscopic and air-stable, allowing routine handling without special precautions. In automated peptide synthesis, it is dissolved in DMF with Fmoc-amino acid and DIPEA, agitated for 7 minutes to form acid fluoride before resin coupling.

Advantages: Compared to other fluorinating reagents (e.g., XtalFluor-E/M), it has lower exothermic heat during decomposition, enhancing safety. It avoids the formation of symmetric anhydrides when used with PTF, improving product purity and yield.

Safety Considerations

It decomposes at 370°C, releasing heat, so avoid exposure to high temperatures.

As a fluorinated compound, it should be handled in a well-ventilated fume hood, with appropriate PPE (gloves, goggles, lab coat).

Store in a cool, dry place away from incompatible substances (e.g., strong oxidizers, strong bases).

Shop Raw material TFFH-Detailed Image 1

Basic Info

Product Name:

Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

Other Name:

Methanaminium,N-[(dimethylamino)fluoromethylene]-N-methyl-,hexafluorophosphate(1-) (1:1);Methanaminium,N-[(dimethylamino)fluoromethylene]-N-methyl-,hexafluorophosphate(1-);Tetramethylfluoroformamidinium hexafluorophosphate;TFFH;Fluoro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate;[(Dimethylamino)(fluoro)methylidene]dimethylazanium hexafluoro-λ5-phosphanuide;Nitrogen(2+),[(fluoroamino)carbonyl]tetramethyl-,hexafluorophosphate(1-) (1:2);2448366-74-1

CAS No.:

164298-23-1

Molecular Formula:

C5H12FN2.F6P

InChIKeys:

InChIKey=ZAVXOOLKAGPJPI-UHFFFAOYSA-N

Molecular Weight:

264.12

Exact Mass:

264.06300

HScode:

29252900

Categories:

Organic Reagents

Characteristics

PSA:

6.2

XLogP3:

3.52800

Appearance:

Yellow Powder

Melting Point:

110 °C

Water Solubility:

Soluble in water.

Storage Conditions:

2-8°C

See More Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1) Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1) Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Africa	TCFH (Tetramethylfluoroformamidinium hexafluorophosphate)	5 KG	Jan 12, 2026
South Africa	TCFH (Tetramethylfluoroformamidinium hexafluorophosphate)	5 KG	Jan 13, 2026

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Raw material TFFH

Product Description

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