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High Quality Selank

Name: High Quality Selank
Brand: Guangsheng
SKU: pr2601151141
Price: 45 USD
Availability: InStock

TDS 41 Inquiries

Unit Price:

$45/UNIT FOB

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CAS No.:

129954-34-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Guangzhou

Brand:

Guangsheng

Packaging:

5-10mg*10vials

Price valid (until):

2030-09-10

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Guangsheng Technology co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

beaty prodt

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Product Details
Seller Information
Inquiry History

Description

Product Detail

Name: Lynn
Wechat： 15914422644

Tel：+86 15914422644

Whatsapp: +852 6252 8290

Email： guangsheng 5 @zgguangsheng.com

1. Core Molecular & Physicochemical Specifications

Item	Details
Chemical Name	Selank; Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
CAS Number	129954-34-3
Amino Acid Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro (7 residues, tuftsin analog)
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	751.9 Da
Purity Standard	≥99% (HPLC); single impurity ≤0.5%
Formulation	White/off-white lyophilized powder (research grade); typical specs: 10mg/50mg/100mg per vial
Stability	Stable at -20°C for 2–3 years; 2–8°C for 3–6 months. Avoid repeated freeze-thaw
Solubility	Soluble in sterile water/normal saline (pH 6.0–7.0); insoluble in organic solvents
Reconstitution	Dissolve in sterile water for injection; use within 72 hours at 2–8°C after reconstitution

2. Mechanism of Action

Selank exerts synergistic effects via multiple pathways for neuropsychiatric and immune regulation:

GABAergic Modulation: Allosterically enhances GABA-A receptor activity, reducing neural excitability without sedation (unlike benzodiazepines).
Serotonin/Dopamine Balance: Upregulates serotonin metabolism and modulates dopamine, stabilizing mood and stress resilience.
BDNF Elevation: Promotes neurotrophic factor expression, supporting neuroplasticity, learning, and memory.
Cytokine Regulation: Modulates IL-6 and T-helper cell cytokines, linking neuroimmune communication and reducing neuroinflammation.
HPA Axis Modulation: Attenuates stress-induced cortisol release, improving long-term stress adaptation.

3. Biological Functions & Research Applications

3.1 Core Biological Effects

Anxiolytic Action: Comparable to benzodiazepines without sedation/dependence; relieves GAD/PTSD symptoms rapidly (hours to days).
Cognitive Enhancement: Improves learning, memory, and focus via BDNF; mitigates age-related cognitive decline.
Antidepressant-like Effects: Augments traditional antidepressants; normalizes stress-induced behavioral changes.
Immunomodulation: Balances pro/anti-inflammatory cytokines; enhances NK cell activity and antiviral responses.
Neuroprotection: Protects against ischemic/hypoxic brain injury; slows neurodegeneration via BDNF upregulation.

3.2 Research & Clinical Applications

Application Field	Usage Scenarios
Anxiety Disorders	GAD, PTSD, and situational anxiety; non-sedating alternative to benzodiazepines
Cognitive Impairment	Age-related decline, ADHD, and post-stroke cognitive deficits; enhances focus/memory
Depression Adjuvant	Combinatorial therapy to boost antidepressant efficacy and reduce side effects
Neuroinflammation	Multiple sclerosis, traumatic brain injury, and neuroinflammatory models
Stress Resilience	HPA axis modulation for chronic stress; improves stress-induced fatigue and mood swings
Immune-Neuro Axis Research	Studies on neuroimmune cross-talk in mood and cognitive disorders

4. Production & Quality Control

4.1 Manufacturing Process

Solid-Phase Peptide Synthesis (SPPS): Fmoc chemistry assembles the 7-amino acid sequence, purified via RP-HPLC to ≥99% purity.
Lyophilization: Freeze-drying forms stable powder, extending shelf-life and enabling cold-chain storage/transport.

4.2 Quality Testing Standards

Test Item	Specification	Detection Method
Purity	≥99%	RP-HPLC (C18 column, gradient elution)
Single Impurity	≤0.5%	HPLC
Water Content	≤0.5%	Karl Fischer titration
Endotoxin	≤0.1 EU/mg	Limulus Amebocyte Lysate (LAL) test
Heavy Metals	≤10 ppm	ICP-MS
Identity	Conforms to reference standard	Mass spectrometry (MS), amino acid analysis

5. Administration, Safety & Handling

5.1 Administration Routes & Dosage

Intranasal Spray: Most common; 300–900 mcg/day (1–3 divided doses) for anxiety/cognition.
Subcutaneous Injection: Research use; 500–1000 mcg/day (1–2 doses) for neuroprotection/immune modulation.

5.2 Safety Profile

Low Toxicity: Transient nasal irritation, mild headache, or dizziness (rare, dose-dependent, reversible).
Non-Addictive: No dependence/withdrawal (unlike benzodiazepines); no sedation or cognitive impairment.
Contraindications: Hypersensitivity to Selank; pregnancy/lactation (limited data); caution in severe renal/hepatic dysfunction.

5.3 Handling Recommendations

Storage: -20°C dry/dark environment; avoid light/moisture.
Transport: Cold chain (2–8°C) to preserve stability.
Research-Only Use: For R&D; not for human clinical use without regulatory approval.
Disposal: Follow local chemical waste guidelines to prevent environmental contamination.

6. Advantages of High-Purity Selank Powder

Reliable Research Data: Minimal impurities ensure consistent in vitro/in vivo experimental results.
Pharmaceutical Compatibility: Meets GMP standards for preclinical formulation development.
Long-Term Stability: Low impurity content reduces degradation risk, extending shelf-life.
Reduced Side Effects: High purity minimizes non-specific reactions in research models.

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ECHEMI Editorial Reference

Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genesIl2rgandXcr1in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.
SELANK Synthetic is a single, non-glycosylated polypeptide chain containing 7 amino acids, having a molecular mass of 751.89 Dalton and a Molecular formula of C33H57N11O9.

Research & Reference Note

High Quality Selank is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

Selank peptide

Other Name:

Selank peptide;SelankAcetate;PL14736;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline;L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE;H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH;SLANK;Selank peptid

CAS No.:

129954-34-3

Molecular Formula:

C33H57N11O9

InChIKeys:

JTDTXGMXNXBGBZ-YVHUGQOKSA-N

Molecular Weight:

751.87

Exact Mass:

751.43407244

EC Number:

232-660-2

UNII:

TS9JR8EP1G

Categories:

Other Chemical Drugs

Characteristics

Density:

1.53±0.1 g/cm3(Predicted)

Melting Point:

134-136 °C

PKA:

3.43±0.20(Predicted)

See More Selank peptide Properties 

Seller Information

Business Type:
Trader

Main Products:
beaty prodt

Location:
Yongtai Jinli City Plaza, Baiyun District, Guangzhou City, Guangdong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2023

Inquiry History

41 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Selank 99% Purity 129954-34-3	1 G	Jan 23, 2026
France	peptide vial	10 MT	Oct 7, 2026
Georgia	Selank peptide	10	Sep 27, 2026
United States	Selank peptide	10 MG	Sep 18, 2026
Greece	selank	10 MG	May 20, 2026
United States	N acetyl selank	500 MG	Apr 30, 2026
United States	Selank	100 MG	Apr 24, 2026
Italy	Nacetyl selank	1 MT	Apr 22, 2026
Oman	Selank	1 G	Mar 4, 2026
United States	Selank	30 40' Fcl	Oct 14, 2025
United States	Selank peptide	10 MT	Sep 25, 2026
Iceland	Selank peptide	100 G	Sep 23, 2026
United States	selank	30 MG	May 25, 2026
Brazil	Selank	10 MT	Apr 7, 2026
United States	selank	1 G	Mar 13, 2026
United States	Selank	1 G	Mar 9, 2026
United Kingdom	Selank	1 G	Dec 22, 2025
United States	Selank	20 MG	Nov 10, 2025
United States	NA-Selank Amidate	10 MG	Sep 18, 2025
United Kingdom	Selank	100 MG	Jul 15, 2025

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