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ARA290 (Cibinetide)

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Unit Price:

$75/UNIT FOB

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CAS No.:

1208243-50-8

Grade:

Pharmaceutical Grade

Content:

98%

Port:

Guangzhou

Brand:

Guangsheng

Packaging:

10-16mg*10vials

Price valid (until):

2030-06-18

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Guangsheng Technology co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

beaty prodt

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Name: Lynn
Wechat： 15914422644

Tel：+86 15914422644

Whatsapp: +852 6252 8290

Email： guangsheng 5 @zgguangsheng.com

1. Core Molecular & Physical Traits

Item	Details
Full Name	Pyroglutamate Helix B Surface Peptide (PHBSP), Cibinetide (ARA290)
Amino Acid Sequence	11 amino acids (pGlu‑Glu‑Gln‑Leu‑Glu‑Arg‑Ala‑Leu‑Asn‑Ser‑Ser)
Molecular Weight	1257.32 Da (C₅₁H₈₄N₁₆O₂₁)
CAS No.	1208243-50-8 (free base)
Purity	≥98% (HPLC), endotoxin < 0.01 EU/μg (research grade)
Formulation	Lyophilized acetate salt; reconstitute with sterile water/buffer for subcutaneous/intraperitoneal injection
Pharmacokinetics	Half‑life: 2–4 hours (human); low immunogenicity, rapid tissue distribution

2. Mechanism of Action

ARA290 selectively binds to the innate repair receptor (IRR)—a heteromer of erythropoietin receptor (EPOR) and β‑common receptor (CD131)—avoiding EPOR homodimers that drive erythropoiesis. Key signaling pathways activated:

JAK2/STAT5: Suppresses pro‑inflammatory cytokines (TNF‑α, IL‑1β) and reduces oxidative stress.
PI3K/Akt: Inhibits apoptosis, enhances cell survival, and promotes small nerve fiber regeneration.
MAPK/ERK: Boosts tissue repair, angiogenesis, and wound healing.

Its receptor selectivity eliminates erythropoietic side effects of native EPO, focusing on tissue protection and repair.

3. Key Biological Effects & Research Applications

Core Effects (Preclinical & Clinical)

Neuroprotection/Regeneration: Promotes small nerve fiber regrowth, reduces neuropathic pain (diabetic/sarcoidosis‑related), and improves corneal nerve density.
Anti‑Inflammatory: Attenuates pro‑inflammatory mediator expression, mitigating organ damage from ischemia‑reperfusion and autoimmune conditions.
Organ Protection: Preserves renal, myocardial, retinal, and pancreatic islet function in injury/disease models.
Wound Healing: Accelerates closure of dermal ulcers and biopsy wounds.
Metabolic Support: Improves insulin sensitivity and protects against high glucose‑induced cell damage.

Research & Clinical Focus Areas

Area	Applications
Neuropathy	Diabetic neuropathy, small fiber neuropathy, traumatic brain injury (TBI)
Inflammatory Diseases	Sarcoidosis, autoimmune disorders, ischemic organ injury
Organ Transplantation	Pancreatic islet protection and engraftment enhancement
Metabolic Disorders	Insulin resistance, diabetic retinopathy
Wound Care	Decubitus ulcers, dermal injury repair

4. Dosing & Administration (Research/Clinical)

Model/Setting	Route	Dose Range	Frequency	Cycle
Rodents	IP/SC	0.8–8 nmol/kg (renal injury); 30 μg/kg (TBI)	Daily	2–4 weeks
Humans (Clinical)	SC	2–4 mg	Once daily/every other day	4–12 weeks (neuropathy trials)

Note: Higher doses may increase injection site reactions; dose adjustment for renal/hepatic impairment is recommended.

5. Safety & Precautions

Common Side Effects (Clinical)

Mild injection site erythema/edema.
Transient fatigue or headache (rare, dose‑related).
No significant erythropoiesis stimulation or hypertension (vs. EPO).

Critical Warnings

For research/clinical development only; not approved for human therapeutic use outside trials.
Store at -20°C; reconstituted solution stable for 72 hours at 2–8°C.
Avoid use in patients with hypersensitivity to peptide components.

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Basic Info

Product Name:

Cibinetide

Other Name:

ARA-290 (Cibinetide);ARA290, >98%;ARA290,Cibinetide, >98%;ARA290;WZTIQQBMSJTRBR-MUZUOSMHSA-N;ara290/Poziotinib;L-Serine, 5-oxo-L-prolyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-α-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-;ARA-290(Cibinetide) acetate

CAS No.:

1208243-50-8

Molecular Formula:

C51H84N16O21

InChIKeys:

WZTIQQBMSJTRBR-WYKNNRPVSA-N

Molecular Weight:

1257.31

EC Number:

200-001-8

Color/Form:

White to off-white

Categories:

Other Chemical Drugs

Characteristics

Density:

1.56±0.1 g/cm3(Predicted)

PKA:

2.90±0.10(Predicted)

Seller Information

Business Type:
Trader

Main Products:
beaty prodt

Location:
Yongtai Jinli City Plaza, Baiyun District, Guangzhou City, Guangdong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2023

Inquiry History

20 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Factory Supply 99% Purity Ara 290 Peptides Raw Lyophilized Powder CAS 1208243-50-8	1 G	Oct 29, 2023
United States	ARA 290	1 G	Apr 13, 2026
United States	ARA-290 Peptide	1 G	Feb 6, 2026
United States	ARA-290	10 PCS	Nov 15, 2025
Thailand	Cibinetide	200 KG	May 10, 2025
Lithuania	ARA 290	60	Nov 28, 2023
United States	ARA-290 10mg	100 PCS	Apr 17, 2026
United States	ARA-290	10 MT	May 10, 2024
Denmark	Cibinetide	5 G	Feb 11, 2024
Lithuania	ARA 290	10	Nov 28, 2023
United States	ARA 290	1 KG	Jun 15, 2026
Belgium	ARA290	1 KG	May 20, 2026
United States	Reta	60	May 4, 2026
United States	ARA-290 Lyophilized	800 MG	Apr 17, 2026
United States	Ara290	1 G	Apr 17, 2026
Nigeria	Snap 8	100 PCS	Apr 10, 2026
United States	Ara 290	1 G	Apr 8, 2026
United States	ARA-290	1 G	Apr 5, 2026
Bulgaria	ARA-290 98%	5 KG	Jun 5, 2025
Denmark	Cibinetide	5 G	Feb 10, 2024

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