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99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60

Name: 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60
Brand: YUNI
SKU: pr2601151522
Price: 35 USD
Availability: InStock

7096 Inquiries

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CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

HONGKONG

Brand:

YUNI

Packaging:

10mg*10vials/box

Price valid (until):

2026-02-15

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Guangsheng Technology co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

beaty prodt

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Name: Lilian
Wechat：yi970803bo

Whatsapp:+852 61856606

Email：guangsheng2@zgguangsheng.com

Shop 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60-Detailed Image 1

Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

Retatrutide is a new type of multi-target peptide drug developed by Eli Lilly and Company of the United States, it is a trip

le receptor agonist of GLP-1R/GIPR/GCGR. Its core mechanism is to regulate the metabolic process by activating glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) receptors at the same time, and is used for the treatment of obesity and type 2 diabetes. The following are its key features: Shop 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60-Detailed Image 2

Items	Specifications
Product Name	Retatrutide
CAS No.	2381089-83-2
Molecular Formula	C187H291N45O59
Appearance	White Powder
Packaging	10mg/vial, 10vials/box
MOQ	10 vials

Mechanism of Action and Molecular Structure of Retatrutide:

1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote insulin secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification, supporting subcutaneous injection once a week.

Shop 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60-Detailed Image 3

Clinical Effects and Core Data of Retatrutide:

1) Outstanding Weight Loss Effect:
- 48 weeks of treatment: The average weight loss in the 12mg dose group reached 24.2%, significantly better than existing drugs (such as Semaglutide and Tirzepatide).
- Gender differences: Women have a more significant weight loss effect (28.5% vs. men 21.2%).
- Dose dependence: From the starting dose of 2mg to 12mg, the weight loss ratio increases with the dose.

Comparison of Weight Loss Effects at Different Doses (48-Week Data):

Doses	4mg	8mg	12mg
Weight Loss Ratio	~8.7%	~17.5%	~24.2%
Waist Circumference Reduction	-2.1cm	-6.1cm	-10.2cm

Before and after weight loss：

2) Comprehensive Improvement of Metabolism:

- Blood sugar control: Significantly reduce glycated hemoglobin (HbA1c), and doses above 4mg are better than dulaglutide.
- Cardiovascular metabolism: Improve triglyceride, cholesterol and blood pressure levels, potentially reducing cardiovascular risks.
- Expanded indications: Used in research for metabolic-related diseases such as polycystic ovary syndrome (PCOS).

Shop 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60-Detailed Image 5

Indications and Efficacy:

★ Obesity Treatment:
In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%.

★ Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD):
Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis.

★ Type 2 Diabetes:
Significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control.

★ Potential Cardiovascular Benefits:
Animal studies have shown that it may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.

Shop 99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60-Detailed Image 6

Market Prospects and Challenges:

◎ Differentiation Advantages:
Compared with existing GLP-1 single-target (such as Semaglutide) or dual-target drugs (such as Tirzepatide), the triple mechanism of Retatrutide has greater potential in weight loss and metabolic improvement.

◎ Cost and Accessibility:
Currently, the production cost of peptide drugs is relatively high, but the long-acting properties of Retatrutide may reduce the frequency of medication and improve patient compliance.

ECHEMI Editorial Reference

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.

Basic Info

Product Name:

Retatrutide

Other Name:

Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

CAS No.:

2381089-83-2

InChIKeys:

MLOLQJNKXBNWFW-SAGGEDDASA-N

Molecular Weight:

EC Number:

200-001-8

Color/Form:

White lyophilized

Categories:

Other Chemical Drugs

Characteristics

Water Solubility:

Soluble in water (5mg/ml).

Storage Conditions:

-20°C

Critical Temperature & Pressure:

-20°C

Research

Class:

Triple agonist — GCGR, GIPR, GLP-1R

Status:

Investigational (Phase 3)

Mechanism:

Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

EC50 (Human GCGR):

5.79 nM

EC50 (Mouse GIPR):

0.191 nM

EC50 (Mouse GLP1R):

0.794 nM

EC50 (Mouse GCGR):

2.32 nM

EC50 (Human GLP1R):

0.775 nM

EC50 (Human GIPR):

0.0643 nM

Source:

Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

Clinical Development:

NCT04881760; NCT05882045; NCT06354660

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA

Disclaimer:

Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

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Seller Information

Business Type:
Trader

Main Products:
beaty prodt

Location:
Yongtai Jinli City Plaza, Baiyun District, Guangzhou City, Guangdong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2023

Inquiry History

7096 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Retatrutide 2381089-83-2	3 MT	Mar 28, 2026
United Kingdom	Retatrutide - 2381089-83-2	1 G	Feb 10, 2026
United States	Retatrutide CAS 2381089-83-2 10mg vial	20 MT	Mar 7, 2026
United States	Factory Retatrutide API 99% Purity CAS 2381089-83-2	5 KG	Nov 10, 2025
United Kingdom	Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA	1 MT	Mar 22, 2026
United States	2381089-83-2	100 G	Jul 14, 2026
United States	2381089-83-2	100 G	Feb 24, 2026
United States	2381089-83-2	100 MT	Dec 9, 2023
United States	Retatrutide 2381089-83-2	200 MG	May 16, 2026
United Kingdom	2381089-83-2 retatrutide	300 MG	Feb 13, 2026
United States	Retatrutide 2381089-83-2 wholesale	500 MT	Nov 3, 2023
United States	Retatrutide CAS 2381089-83-2 99%	10 PCS	Feb 21, 2026
Austria	Retatrutide CAS 2381089-83-2 10mg vial	20 PCS	Feb 10, 2026
Poland	CAS 2381089-83-2 (Custom Peptide)	40 MT	Apr 10, 2026
Austria	Peptide Retatruide CAS 2381089-83-2	100 MT	Apr 4, 2026
United States	GLP-1 / GIP Retatrutide cas 2381089-83-2	1 MT	Oct 16, 2024
United States	Retatrutide 99% High Quality CAS 2381089-83-2	1 G	Jan 23, 2026
United States	Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2	10	Oct 21, 2023
Palestine	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	10 MG	Mar 16, 2026
United States	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	20 MG	Feb 4, 2026

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99% White Powder High-Purity Peptide RT Retatrutide RT5 RT10 RT15 RT20 RT30 RT60

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