CAS: 40077-57-4 VIP

  Product Detail  

I. Core Basic Information

II. Mechanism of Action

1. Receptor Activation: Binds to VPAC1/VPAC2/PAC1 receptors, activating cAMP and Ca²⁺ signaling pathways to regulate target cell functions.
2. Smooth Muscle Relaxation: Induces vasodilation, bronchodilation, and inhibition of gastrointestinal/genital smooth muscle contraction.
3. Immunomodulation: Suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) via NF-κB pathway inhibition; modulates T-cell proliferation.
4. Neuroprotection: Promotes neuronal survival, enhances neurotrophic factor release, and regulates circadian rhythms (SCN synchronization).

III. Key Biological Activities & Physiological Roles

IV. Research Applications & Therapeutic Potential

1. Research Use: Tool compound for studying GPCR signaling, neuroimmunology, and circadian biology; used in corneal preservation and organ culture.
2. Therapeutic Candidates:
   • Respiratory: Acute respiratory distress syndrome (ARDS), pulmonary fibrosis, asthma.
   • Metabolic: Type 2 diabetes (glucose control + weight management).
   • Gastrointestinal: Inflammatory bowel disease (IBD), peptic ulcers.
   • Neurological: Neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s).
   
   

V. Handling & Precautions

1. Reconstitution: Dissolve in sterile water or 0.1% acetic acid (typical solubility: 1–20 mg/mL); avoid repeated freeze-thaw cycles.
2. Safety: For research use only; avoid contact with skin/eyes; use PPE (gloves, lab coat); perform patch tests for biological applications.
3. Compatibility: Stable with most buffers; avoid strong oxidizing agents or extreme pH (<4 or >8).

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